Genetic Variability and Sequence Relatedness of Matrix Protein in Viruses of the Families Paramyxoviridae and Pneumoviridae
Conclusion: While we have confirmed that M proteins were conserved among individual viruses, any changes that are observed should be given attention and further researched. Of special interest is inclusion of HPIV2 M proteins in this analysis, as these proteins have not been studied to the same extent as other paramyxoviruses.Intervirology (Source: Intervirology)
Source: Intervirology - March 6, 2018 Category: Virology Source Type: research
Establishment of a Competitive Binding Assay Identifying the Different Characteristics of Neutralizing Epitopes of Hepatitis E Virus
Conclusion: The results of competitive binding assays revealed that the binding of HRP-conjugated 2B1 to p166W01 could not be inhibited by 5G5 or 3G1. Similarly, the binding of HRP-conjugated 4C5 to p166Chn could not be inhibited by 5G5 or 3G1. However, the mAbs 5G5 and 3G1 blocked each other ’s binding to p166W01 and p166Chn, suggesting that common and genotype-specific neutralizing mAbs recognize independent epitopes.Intervirology (Source: Intervirology)
Source: Intervirology - March 6, 2018 Category: Virology Source Type: research
Aichivirus in Children with Diarrhea in Northern Italy
Conclusions: Our results indicate that AiV may be associated with a limited number of diarrhea cases in pediatric patients.Intervirology (Source: Intervirology)
Source: Intervirology - March 2, 2018 Category: Virology Source Type: research
Elevated HPV16 E1 Expression Is Associated with Cervical Cancer Progression
Conclusion: E1 may play a role in cancer development. The detection of E1 mRNA and promoter methylation may be useful as cancer prognostic markers.Intervirology (Source: Intervirology)
Source: Intervirology - March 1, 2018 Category: Virology Source Type: research
Detection of Genotype 1a and 1f of Hepatitis E Virus in Patients Treated at Tertiary Care Hospitals in Central India
Conclusion: HEV is a major aetiological agent of viral hepatitis in central India with adults and males at higher risk of infection. Two subtypes of the virus were detected in the region. Continuous serological surveillance and molecular monitoring will help to understand the epidemiology of HEV infection, outbreak mitigation and aid in providing treatment.Intervirology (Source: Intervirology)
Source: Intervirology - March 1, 2018 Category: Virology Source Type: research
Molecular Epidemiology of Bovine Papillomatosis and Identification of Three Genotypes in Central Iraq
Conclusions: This study confirmed the presence of BPV-1, BPV-2, and BPV-13, which belong to theDeltapapillomavirus genera, for the first time in the DNA of Iraqi cattle. Understanding BPV diversity and epidemiology is of critical importance for starting prevention strategies.Intervirology (Source: Intervirology)
Source: Intervirology - February 9, 2018 Category: Virology Source Type: research
Cytomegalovirus Glycoprotein B Genotype Distribution in Italian Transplant Patients
Conclusions: Mixed infections seem to be prevalent in Italian transplant patients; it is likely that mixed infections are more difficult to control by immunological response in comparison to single genotype infections. In this context, the genetic profile of infecting viruses and relation to clinical outcome should be investigated, also taking into account the CMV-specific cellular immune response.Intervirology (Source: Intervirology)
Source: Intervirology - February 2, 2018 Category: Virology Source Type: research
Type-Specific Human Papillomavirus Prevalence in Iranian Women with Normal Cervical Cytology: The Impact of Current HPV Vaccines
Objective: Human papillomavirus (HPV) vaccination is currently not included in the national vaccination program in Iran. Regional data on the distribution of HPV types in women are important as they can predict the impact of currently available vaccines and help health policy makers to consider all the possibilities with regard to HPV vaccination.Methods: A total of 1,218 Iranian women with normal cervical cytology were included in this study. The presence of the HPV genome was investigated in all specimens by PCR assay, and all HPV-positive samples were genotyped.Results: Totally, HPV was detected in 88 samples (7.2%). Ac...
Source: Intervirology - January 24, 2018 Category: Virology Source Type: research
Survival of Viruses in Water
Water, a frequent vehicle for the transmission of viruses, may permit their survival, but many environmental factors will have an adverse effect on the viral population. Risk evaluation requires identification of these factors and assessment of the inactivation rate of infectious viruses. A higher temperature means a faster reduction of the viral population, as do increased sunlight, higher antimicrobial concentration, or higher oxygen levels. Another documented impact is linked to the presence of indigenous microbial populations: virus survival is higher in sterile water. Environmental factors inactivate viruses through d...
Source: Intervirology - January 9, 2018 Category: Virology Source Type: research
Preliminary Characterization of El Tor Vibriophage M4
Conclusions: M4 belongs to the Myoviridae family and it is generally thermostable. It is prone to destruction by alkali and UV. It also has a large DNA which is densely packed inside of a big capsid.Intervirology (Source: Intervirology)
Source: Intervirology - January 5, 2018 Category: Virology Source Type: research
Resistance-Associated Mutations and Polymorphisms among Integrase Inhibitor-Na ïve HIV-1 Patients in Kuwait
Conclusion: Our results highlight the importance of monitoring the emergence of INSTI-RAMS before and after the initiation of INSTI-based therapy.Intervirology (Source: Intervirology)
Source: Intervirology - December 6, 2017 Category: Virology Source Type: research
CRF35-AD as the Main Circulating Genotype of Human Immunodeficiency Virus Type 1 Infection in Iran: A Phylogenetic and Demographic-Based Study
Finding the predominant circulating subtype of human immunodeficiency virus type 1 (HIV-1) and surveying co-infection with other infectious viruses are crucial to making preventive decisions. To this end, 50 Iranian HIV-positive patients made up of 37 men and 13 women were selected. Most of the HIV-positive patients (70%) were intravenous drug users (IDUs), and 48 and 32% of patients were co-infected with HCV and HBV, respectively. The rate of simultaneous infection with HIV, HCV, and HBV was found to be 6%. The p17 region of thegag and the c2-v5 region of theenv genes were sequenced and then clustered by phylogenetic anal...
Source: Intervirology - November 29, 2017 Category: Virology Source Type: research
Distribution of Hepatitis C Virus Genotypes and Subtypes in the Metropolitan Area of Naples, Italy, in the Era of Interferon-Free Regimens
The objective of this work was to study the distribution of hepatitis C virus (HCV) genotypes and subtypes from 2010 to 2015 in 1,221 anti-HCV/HCV-RNA-positive specimens from patients living in the metropolitan area of Naples, since HCV genotypes and subtypes remain cornerstones in the management of chronic HCV infection even in the directly acting antivirals era.Methods: The study was carried out on 1,221 anti-HCV/HCV-RNA-positive plasma samples collected between April 2010 and December 2015.Results: Of the 1,221 patients enrolled, 633 (51.9%) were males and 588 (48.1%) were females, with a mean age of 60 ± 13 (SD) years...
Source: Intervirology - November 21, 2017 Category: Virology Source Type: research
Intergenotype Recombination among New Norovirus GII.4 Variants in the Complete Genome
In this study, we sought to examine the role that intergenotype recombination has played in the emergence of GII.4 Sydney 2012 variants. The results show that the GII.4 Sydney 2012 variants, Kawasaki194 and CA3477, were intergenotype recombination NoV strains with a GII.4 capsid and a GII.P16 polymerase gene. It has been reported for the first time that GII.4 new variant recombinants come from intergenotype recombination of GII.P16 and GII.4 strains in the complete genome.Intervirology (Source: Intervirology)
Source: Intervirology - November 21, 2017 Category: Virology Source Type: research
Comparing the Clinical Features and Outcomes of Acute Hepatitis E Viral Infections with Those of Acute Hepatitis A, B, and C Infections in Korea
Conclusion: Our findings indicate that HEV infection in Korea is frequently transmitted through the consumption of raw meat and may cause acute or chronic liver disease.Intervirology (Source: Intervirology)
Source: Intervirology - November 16, 2017 Category: Virology Source Type: research
