HIV-1 Subtype Diversity and Prevalence of Primary Drug Resistance in a Single-Center Pediatric Cohort in Germany
Conclusions: We report a predominance of non-subtype-B infections and a higher prevalence of DRMs compared to other pediatric cohorts from resource-rich settings. The difference in HIV-1 subtype distribution is due to the fact that a relevant proportion of pediatric patients in Germany are immigrants from high-prevalence settings in sub-Saharan Africa where non-B subtypes predominate.Intervirology 2016;59:301-306 (Source: Intervirology)
Source: Intervirology - July 4, 2017 Category: Virology Source Type: research
Contribution of Next-Generation Sequencing to Aquatic and Fish Virology
The recent technological advances in nucleic acid sequencing, called next-generation sequencing (NGS), have revolutionized the field of genomics and have also influenced viral research. Aquatic viruses, and especially those infecting fish, have also greatly benefited from NGS technologies, which provide a huge amount of molecular information at a low cost in a relatively short period of time. Here, we review the use of the current high-throughput sequencing platforms with a special focus on the associated challenges (regarding sample preparation and bioinformatics) in their applications to the field of aquatic virology, es...
Source: Intervirology - June 30, 2017 Category: Virology Source Type: research
Generation of a DNA-Launched Reporter Replicon Based on Dengue Virus Type 2 as a Multipurpose Platform
(Source: Intervirology)
Source: Intervirology - June 22, 2017 Category: Virology Source Type: research
A Possible Role of Therapeutic Drug Monitoring in Virological Breakthrough during Simeprevir and PEG-IFN Treatment in HCV-4
Intervirology 2016;59:283-284 (Source: Intervirology)
Source: Intervirology - June 21, 2017 Category: Virology Source Type: research
Resistance of Enteric Viruses on Fomites
Human enteric viruses are associated with several clinical features, especially gastroenteritis. Large amounts of these viruses can be released in the environment and spread to people. Enteric viruses are nonenveloped viruses and have displayed good survival in the environment. They can be significantly resistant in food and water but also on fomites, and this is thought to play a role in transmission, leading to sporadic cases or outbreaks. The survival of enteric viruses on fomites relies on many factors including the virus itself, fomite properties, and extrinsic environmental factors such as temperature or relative hum...
Source: Intervirology - June 14, 2017 Category: Virology Source Type: research
Effect of Maxing Shigan Tang on H1N1 Influenza A Virus-Associated Acute Lung Injury in Mice
Conclusion: MST improves H1N1-associated ALI maybe through targeting ANGPTL4 in mice.Intervirology 2016;59:267-274 (Source: Intervirology)
Source: Intervirology - May 3, 2017 Category: Virology Source Type: research
The Genotyping Resistance Profile of the Pol Gene Detected in Blood of Newly Diagnosed HIV-Positive Men Is Durably Archived in the Gut Whatever the Time of Initiation of cART
Conclusion: These data suggest that resistance mutations harbored by the main HIV strain in plasma at the time of diagnosis are durably archived in DNA cells whatever the delay between infection and initiation of therapy in patients well controlled by cART.Intervirology 2016;59:256-261 (Source: Intervirology)
Source: Intervirology - April 13, 2017 Category: Virology Source Type: research
Frequent pUL27 Variations in HIV-Infected Patients
Conclusion: HCMV pUL27 is highly variable in adult immunocompromised HIV-positive patients.Intervirology 2016;59:262-266 (Source: Intervirology)
Source: Intervirology - April 12, 2017 Category: Virology Source Type: research
The Genotyping Resistance Profile of the < b > < i > Pol < /i > < /b > Gene Detected in Blood of Newly Diagnosed HIV-Positive Men Is Durably Archived in the Gut Whatever the Time of Initiation of cART
Conclusion: These data suggest that resistance mutations harbored by the main HIV strain in plasma at the time of diagnosis are durably archived in DNA cells whatever the delay between infection and initiation of therapy in patients well controlled by cART.Intervirology 2016;59:256-261 (Source: Intervirology)
Source: Intervirology - April 12, 2017 Category: Virology Source Type: research
Low Risk of Developing Chronic Hepatitis E in Heart Transplant Recipients: A Prospective 2-Year Follow-Up Study
Intervirology 2016;59:254-255 (Source: Intervirology)
Source: Intervirology - April 12, 2017 Category: Virology Source Type: research
Complete Genome Sequence of Proteus mirabilis Phage pPM_01 Isolated from Raw Sewage
Conclusions: The inability to lysogenize a host, the absence of endotoxin genes in the annotated genome, and the lytic behavior suggest phage pPM_01 as a possible safe biological candidate to controlP. mirabilis infection.Intervirology 2016;59:243-253 (Source: Intervirology)
Source: Intervirology - April 11, 2017 Category: Virology Source Type: research
Predominance of G9P[4] Rotavirus from Children with Acute Gastroenteritis in Northwestern Mexico
This study was conducted to examine the circulating RVA strains in the northwest region of Mexico. RVA strains collected from stool samples of children were genotyped, and their partial sequences were analyzed. RT-PCR of the VP4 and VP7 genes showed the partial G9P[4] genotype in all the samples. Sequencing and phylogenetic analysis of the partial VP7 gene amplicons of 10 strains showed that they clustered in the RVA G9 lineage III, and 7 of them showed 100% identity with the reference strain LB1562, which was collected in the USA 2 years earlier. The amino acid sequences of the VP7 and VP4 antigenic regions were highly co...
Source: Intervirology - March 23, 2017 Category: Virology Source Type: research
Antiviral and Immunomodulatory Effects of Norantea brasiliensis Choisy on Dengue Virus-2
Conclusion: During in vitro DENV infection,N. brasiliensis Choisy exerts both antiviral and immunomodulatory effects that are likely associated, considering that less viral load may lead to less immunostimulation.Intervirology 2016;59:217-227 (Source: Intervirology)
Source: Intervirology - March 23, 2017 Category: Virology Source Type: research
Antiviral and Immunomodulatory Effects of < b > < i > Norantea brasiliensis < /i > < /b > Choisy on Dengue Virus-2
Conclusion: During in vitro DENV infection,N. brasiliensis Choisy exerts both antiviral and immunomodulatory effects that are likely associated, considering that less viral load may lead to less immunostimulation.Intervirology 2016;59:217-227 (Source: Intervirology)
Source: Intervirology - March 23, 2017 Category: Virology Source Type: research
Peptides Derived from Glycoproteins H and B of Herpes Simplex Virus Type 1 and Herpes Simplex Virus Type 2 Are Capable of Blocking Herpetic Infection in vitro
Conclusion: Four AVPs (CB-1, CB-2, U-1, and U-2) derived from gB and gH were designed and synthetized, none of which showed high levels of toxicity in Vero cells. The U-1 and U-2 gB-derived AVPs showed high virucidal and antiviral activities against both HSV-1 and HSV-2. The gH-derived peptide CB-1 showed high virucidal and antiviral activities against HSV-2, while CB-2 showed similar results against HSV-1. The peptides CB-1 and CB-2 showed higher IC50 values than the U-1 and U-2 peptides.Intervirology 2016;59:235-242 (Source: Intervirology)
Source: Intervirology - March 23, 2017 Category: Virology Source Type: research
