Evaluation of MicroRNA Expression Pattern (miR-28, miR-181a, miR-34a, and miR-31) in Patients with COVID-19 Admitted to ICU and Diabetic COVID-19 Patients
This study aimed to evaluate whether PBMC miRNAs are diagnostic biomarkers to screen the ICU COVID-19 and diabetic COVID-19 subjects.Methods: Candidate miRNAs were selected through previous studies, and then the PBMC levels of selected miRNAs (miR-28, miR-31, miR-34a, and miR-181a) were measured via quantitative reverse transcription PCR. The diagnostic value of miRNAs was determined by the receiver operating characteristic (ROC) curve. The bioinformatics analysis was utilized to predict the DEM genes and relevant bio-functions.Results: The COVID-19 patients admitted to ICU had significantly greater levels of selected miRN...
Source: Intervirology - March 7, 2023 Category: Virology Source Type: research
Evaluation of MicroRNAs expression pattern (miR-28, miR-181a, miR-34a, and miR-31) in Patients with COVID-19 Admitted to ICU, and Diabetic COVID-19 patients
This study aimed to evaluate whether PBMC miRNAs are diagnostic biomarkers to screen the ICU COVID-19 and diabetic-COVID-19 subjects.
Methods: Candidate miRNAs were selected through previous studies, and then the PBMC levels of selected miRNAs (miR-28, miR-31, miR-34a, and miR-181a) were measured via quantitative reverse transcription PCR. The diagnostic value of miRNAs was determined by the receiver operating characteristic (ROC) curve. The bioinformatics analysis was utilized to predict the DEMs genes and relevant bio-functions.
Results: The COVID-19 patients admitted to the ICU had significantly greater levels of sele...
Source: Intervirology - March 7, 2023 Category: Virology Source Type: research
Clinical Value of Serum miR-106a in the Diagnosis and Prognosis of Human Papillomavirus-Positive Cervical Cancer
Conclusion: High expression of miR-106a assists in the diagnosis of HPV-positive CC and predicts poor prognosis.Intervirology 2023;66:54 –62 (Source: Intervirology)
Source: Intervirology - January 16, 2023 Category: Virology Source Type: research
Clinical value of serum miR-106a in the diagnosis and prognosis of human papillomavirus-positive cervical cancer
Conclusion: High expression of miR-106a assists the diagnosis of HPV-positive CC and predicts poor prognosis. (Source: Intervirology)
Source: Intervirology - January 16, 2023 Category: Virology Source Type: research
Broad Antiviral Spectrum of Glycyrrhizic Acid for Human and Veterinary Medicine: Reality or Fiction?
Background: Emerging virus infections provoke health problems in people and animals, which generate social and economic issues worldwide. This has spurred the search for new pharmacological strategies to confront them.Summary: The purpose of this review is to draw the reader ’s attention to pharmacological evaluations of glycyrrhizic acid (GA) and its analogs on the broad range of viruses known in human and veterinary medicine. GA is the main water-soluble constituent extracted from the roots of plants from the genusGlycyrrhiza, commonly known as licorice root. It has long been used due to its broad spectrum of bioactivi...
Source: Intervirology - December 1, 2022 Category: Virology Source Type: research
Broad antiviral spectrum of glycyrrhizic acid for human and veterinary medicine: reality or fiction?
Background: Emerging virus infections provoke health problems in people and animals, which generate social, and economic issues worldwide. This has spurred the search for new pharmacological strategies to confront them. Summary: The purpose of this review is to draw the reader's attention to pharmacological evaluations of glycyrrhizic acid (GA) and its analogs on the broad range of viruses known in human and veterinary medicine. GA is the main water-soluble constituent extracted from the roots of plants from the genus Glycyrrhiza, commonly known as licorice root. It has long been used due to its broad spectrum of bioactivi...
Source: Intervirology - December 1, 2022 Category: Virology Source Type: research
Porcine Endogenous Retrovirus Induces CXCL10 in Human Monocytes and Monocyte-Derived Primary Cells
Conclusion: Our findings highlight PERVs as inducers of the pro-inflammatory chemokine CXCL10 and other innate immune responses in human monocytes and derived cells with potential implications in the context of xenotransplantation.Intervirology (Source: Intervirology)
Source: Intervirology - November 16, 2022 Category: Virology Source Type: research
Porcine Endogenous Retrovirus Induces CXCL10 in Human Monocytes and Monocyte-Derived Primary Cells
Conclusion: Our findings highlight PERVs as inducers of the pro-inflammatory chemokine CXCL10 and other innate immune responses in human monocytes and derived cells with potential implications in the context of xenotransplantation. (Source: Intervirology)
Source: Intervirology - November 16, 2022 Category: Virology Source Type: research
PERV induces CXCL10 in human monocytes and monocyte-derived primary cells
Conclusion: Our findings highlight PERVs as inducers of the pro-inflammatory chemokine CXCL10 and other innate immune responses in human monocytes and derived cells with potential implications in the context of xen otransplantation. (Source: Intervirology)
Source: Intervirology - November 16, 2022 Category: Virology Source Type: research
Acknowledgement to Reviewers
Intervirology 2022;65:236 (Source: Intervirology)
Source: Intervirology - October 21, 2022 Category: Virology Source Type: research
Rotavirus quantification in children with acute gastroenteritis
Conclusions: Our results showed that RV was present in around 34.7% of children hospitalized for AGE, a rate similar to those reported in previous studies conducted elsewhere which were in the range of 33–75%. Our protocol are able to quantify the abs olute number of viral particle/mg of feces. The clinical utility of quantitative molecular assays, such as Rotavirus viral load, will be markedly improved. (Source: Intervirology)
Source: Intervirology - October 14, 2022 Category: Virology Source Type: research
