High Herpesvirus Diversity in Wild Rodent and Shrew Species in Central Africa
Conclusion: The diversity of viruses detected is higher than in similar studies in Europe and Asia. The high diversity of rodent and shrew species occurring in central Africa may be the reason for a higher diversity in herpesviruses in this area.Intervirology (Source: Intervirology)
Source: Intervirology - November 16, 2018 Category: Virology Source Type: research
High-Throughput Sequencing of Putative Novel microRNAs in Rhesus Monkey Peripheral Blood Mononuclear Cells following EV71 and CA16 Infection
Conclusion: Our results not only revealed potential biomarkers or targets for the diagnosis and treatment of HFMD, but also provided new insights to explore the mechanisms of EV71 and CA16 pathogenesis.Intervirology (Source: Intervirology)
Source: Intervirology - November 7, 2018 Category: Virology Source Type: research
A Molecular Epidemiological Investigation of Carriage of the Adeno-Associated Virus in Murine Rodents and House Shrews in China
Conclusions: A high prevalence of rat AAV that was highly conserved within theCap gene was found in 3 common murine rodents and house shrews in China.Intervirology (Source: Intervirology)
Source: Intervirology - November 7, 2018 Category: Virology Source Type: research
High Prevalence of HBV Lamivudine-Resistant Mutations in HBV/HIV Co-Infected Patients on Antiretroviral Therapy in the Area with the Highest Prevalence of HIV/HBV Co-Infection in China
Conclusion: Treating HIV in HIV/HBV co-infection with antiretroviral agents may result in a very high prevalence of HBV 3TC-resistant mutations. TDF could not completely suppress HBV replication.Intervirology (Source: Intervirology)
Source: Intervirology - October 26, 2018 Category: Virology Source Type: research
The Effects of IL10 and NK Cells on the Susceptibility to Mouse Cytomegalovirus in BALB/c Mice despite the Compensation of IFN γ
Conclusion: The functional shortage of NK cells and inappropriate expression of IL10 result in the susceptibility to MCMV in BALB/c mice.Intervirology (Source: Intervirology)
Source: Intervirology - October 18, 2018 Category: Virology Source Type: research
Expression of Duplex shRNAs through a Lentiviral Vector against Cellular and Viral Genes Inflicts Sustained Inhibition of Hepatitis C Virus Replication
Conclusion: A lentiviral vector-based delivery system is a “single-shot” therapeutic strategy. It can express duplex shRNA for long-term synergistic inhibition of HCV and qualify as a promising therapeutic approach for sustained inhibition of HCV replication.Intervirology (Source: Intervirology)
Source: Intervirology - October 4, 2018 Category: Virology Source Type: research
Hepatitis E Virus Genotype 3 Genomes from RNA-Positive but Serologically Negative Plasma Donors Have CUG as the Start Codon for ORF3
This study was undertaken to characterize HEV genomes in asymptomatic plasma donors from Sweden and Germany lacking anti-HEV. Complete open reading frames (ORFs) were obtained from HEV strains in 5 out of 18 plasma donors who tested positive for HEV RNA. All strains had CUG as the start codon of ORF3, while 147 GenBank strains all had AUG as the start codon (p #x3c; 0.0001). This substitution was found in both interrelated and unrelated strains belonging to different phylogenetic clades. The HEV strains from the seronegative plasma donors had no other substitution in common, which may be why the CUG substitution seems to e...
Source: Intervirology - October 4, 2018 Category: Virology Source Type: research
Hepatitis E Virus Genotype 1 and Hepatitis A Virus Dual Infection in Pediatric Patients with a Low Socioeconomic Status from Mexico
Conclusions: An elevated rate of G1 RNA was detected. Hepatitis E seems to be a neglected disease in Mexico and epidemic strains of HEV are likely to play a role as causative agents of acute hepatitis in highly exposed children. Although HAV is endemic in Mexico, an HEV-RNA detection rate of 17% in co-infected samples shows the need for screening for HEV as a part of future vaccination strategies.Intervirology (Source: Intervirology)
Source: Intervirology - October 4, 2018 Category: Virology Source Type: research
Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH
Transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV) are similar coronaviruses, causing diseases characterized by vomiting, diarrhea, and death from severe dehydration in piglets. Thus, they have caused huge losses to the swine-breeding industry worldwide. Nowadays, they are easily transmitted among the continents via vehicles, equipment, and cargo. Both viruses establish an infection in porcine enterocytes in the small intestine, and their spike (S) proteins play a key role in the virus-cell binding process under unfavorable conditions when the intestine with a low pH is filled with a thic...
Source: Intervirology - September 3, 2018 Category: Virology Source Type: research
RNAi Targeting of Human Metapneumovirus < b > < i > P < /i > < /b > and < b > < i > N < /i > < /b > Genes Inhibits Viral Growth
Conclusion: The findings presented here confirmed the highly potent, sequence-specific antiviral effect of siRNAs targeting the N and P gene of hMPV. These results may facilitate the development of a novel therapeutic agent for hMPV control.Intervirology (Source: Intervirology)
Source: Intervirology - August 24, 2018 Category: Virology Source Type: research
Isolation and Quantification of Mimivirus-Like and Marseillevirus-Like Viruses from Soil Samples in An Aboriginal < b > < i > ( < /i > < /b > Orang asli < b > < i > ) < /i > < /b > Village in Peninsular Malaysia
Conclusion: The ubiquitous nature of both Mimivirus and Marseillevirus is further confirmed in our study as they are detected in higher quantity in soil that is near to water vicinities in an aboriginal village in Peninsular Malaysia. However, this study is limited by our inability to investigate the impact of Mimivirus and Marseillevirus on the aboriginal villagers. More studies on the potential impact of these viruses on human health, especially on the aborigines, are warranted.Intervirology (Source: Intervirology)
Source: Intervirology - August 17, 2018 Category: Virology Source Type: research
Spontaneous Viral Clearance in Sixteen HIV-Infected Patients with Chronic Hepatitis C
Conclusion: A possible drug-induced liver injury and/or suspension of ART may, in some cases, contribute to increasing the chances of spontaneous HCV clearance in HIV-infected patients with CHC.Intervirology (Source: Intervirology)
Source: Intervirology - August 16, 2018 Category: Virology Source Type: research
Association of the Aquaporin 3 Gene Polymorphism (rs2231231) with Epstein-Barr Virus-Associated Cancers in China
Conclusions: TheAQP3 gene polymorphism is associated with a susceptibility to EBVaNPC and EBVaL, and the homozygous AA genotype is more frequently observed in individuals who develop EBVaNPC and EBVaL.Intervirology (Source: Intervirology)
Source: Intervirology - August 15, 2018 Category: Virology Source Type: research
Ultraviolet Inactivation of Chikungunya Virus
Conclusions: The study concludes that the UV-inactivated virus is antigenically stable and could be used in biosafety level 2 settings for different experiments.Intervirology (Source: Intervirology)
Source: Intervirology - July 26, 2018 Category: Virology Source Type: research
Effect of Human Coronavirus OC43 Structural and Accessory Proteins on the Transcriptional Activation of Antiviral Response Elements
Conclusion: Both structural and accessory HCoV-OC43 proteins are able to inhibit antiviral response elements in HEK-293 cells, and to block the activation of different antiviral signaling pathways.Intervirology (Source: Intervirology)
Source: Intervirology - July 24, 2018 Category: Virology Source Type: research
