The HPV16 E1 Carboxyl Domain Provides a Helper Function for Adeno-Associated Virus Replication

Conclusions: The aa 421 –649 helper domain of HPV16 E1 includes the ATP-binding/helicase region of E1 which boosts rAAV production and has homology with the analogous region of parvovirus NS-1/Rep78 by NCBI protein BLAST, suggesting these biochemistries are responsible for the mechanism of action in E1 helper function.Intervirology
Source: Intervirology - Category: Virology Source Type: research