Association of statin use with osteoporosis risk: a drug-targeted Mendelian randomization study
ConclusionThese evidence supported a protective effect of HMGCR-mediated non-HDL cholesterol reduction or statin use against osteoporosis. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 16, 2024 Category: Drugs & Pharmacology Source Type: research
Flavipin from fungi as a potential inhibitor of rheumatoid arthritis signaling molecules
AbstractFlavipin, a fungal lower molecular weight biomolecule (MW 196.16 g/mol), has not been yet extensively studied for beneficial preclinical and clinical applications. In recent years, various preclinical mouse models including adjuvant-induced arthritis (AIA) were employed to understand mechanisms associated with Rheumatoid arthritis (RA) and to develop new therapeutic drugs. In the current study, we studied the inhibitory effect of Flavipin on major signaling molecules involved in the inflammatory response during RA using both in-silico virtual interaction and in vivo mouse model of AIA. Ourin-silico results clarifie...
Source: Inflammopharmacology - February 13, 2024 Category: Drugs & Pharmacology Source Type: research
Role of corticosteroids in the treatment of critically ill sepsis patients: a meta-analysis review
ConclusionIn summary, corticosteroids can reduce the death rate of critically ill sepsis patients to a certain extent and have good clinical application value. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 12, 2024 Category: Drugs & Pharmacology Source Type: research
Does non-steroidal anti-inflammatory drugs-related preemptive analgesia modulate SOCS3/IL-6 pathway in oral surgery?
(Source: Inflammopharmacology)
Source: Inflammopharmacology - February 12, 2024 Category: Drugs & Pharmacology Source Type: research
Isolation, invitro, invivo anti-inflammatory, analgesic and antioxidant potential of Habenaria plantegania Lindl
This study's findings validate the use of this species as traditional use. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 9, 2024 Category: Drugs & Pharmacology Source Type: research
A systematic review of interleukin-31 inhibitors in the treatment of prurigo nodularis
ConclusionsIL-31 inhibitors suggest distinct advantages in improving pruritus, sleep quality, and overall quality of life in subjects with moderate-to-severe PN. Further clinical studies are recommended to compare the effectiveness of these biologics to other therapeutic choices. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 8, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study
AbstractDiabetes mellitus (DM) is a chronic and progressive metabolic disorder that can stimulate neuroinflammation and increase oxidative stress in the brain. Therefore, the present study was aimed to assess the efficacy of ethanolic Terminalia chebula extract against the neurochemical and histopathological changes induced in the brains of diabetic rats. The study clarified the reduction in oxidative stress induced in the brains of diabetic rats by the significant (P ≤ 0.05) increase in levels of the antioxidants with decreasing the peroxidation products via ethanolicT. chebula extract at both doses (400 and 600 m...
Source: Inflammopharmacology - February 8, 2024 Category: Drugs & Pharmacology Source Type: research
Phytochemical analysis and immunomodulatory activities in vitro and in vivo of Aframomum melegueta K Schum seed extracts
AbstractAframomum melegueta K Schum (A. melegueta), an herbaceous plant renowned for its medicinal seeds, was investigated for its potential immunomodulatory effects in vitro and in vivo using ethanolic and methanolic extracts. The immunomodulatory effect was evaluated by measuring antibody titers using the agglutination technique, while anti-inflammatory activity was assessed in a carrageenan-induced mouse paw edema model. In vitro immunomodulatory activity was measured by lysozyme release from neutrophils. Additionally, white blood cell counts were analyzed post-extracts treatment. The MTT assay was employed to determine...
Source: Inflammopharmacology - February 6, 2024 Category: Drugs & Pharmacology Source Type: research
The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer ’s disease: a randomized, double-blind, placebo-controlled study
AbstractThrough modulating effects on the gut-brain axis, probiotics are an effective adjuvant treatment for Alzheimer ’s disease (AD), one of our century’s most important medical care challenges (Agahi et al. Front Neurol 9:662, 2018). This trial aimed to examine the effects of two different single-strain probiotics on oxidative stress and inflammation in patients with mild and moderate AD. This was a 12-week p lacebo-controlled, double-blind, randomized clinical trial performed on 90 patients with AD. Eligible patients were randomly assigned to two different interventions (Lacticaseibacillus rhamnosus HA-114 (7.5 ...
Source: Inflammopharmacology - February 6, 2024 Category: Drugs & Pharmacology Source Type: research
Leaf extracts of eight selected southern African medicinal plants modulate pro-inflammatory cytokine secretion in LPS-stimulated RAW 264.7 macrophages
This study investigates the anti-inflammatory properties of extracts prepared from the leaves of eight southern African medicinal plants used traditionally to treat inflammation and pain. The inhibitory effect of aqueous and ethanol extracts on the release of pro-inflammatory cytokines was determined in lipopolysaccharide (LPS) stimulated and unstimulated RAW 264.7 murine macrophage cells. The levels of interleukin (IL)-1 β, IL-6, tumour necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein (MIP)-2 release were determined using cytokine mult...
Source: Inflammopharmacology - February 4, 2024 Category: Drugs & Pharmacology Source Type: research
D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects
AbstractThe aim of this research was to investigate the effects ofd-limonene on decreasing post-operative adhesion in rats and to understand the mechanisms involved. Peritoneal adhesions were induced by creating different incisions and excising a 1 × 1 cm section of the peritoneum. The experimental groups included a sham group, a control group in which peritoneal adhesions were induced without any treatment, and two treatment groups in which animals receivedd-limonene with dosages of 25 and 50 mg/kg after inducing peritoneal adhesions. Macroscopic examination of adhesions showed that both treatment groups had redu...
Source: Inflammopharmacology - February 3, 2024 Category: Drugs & Pharmacology Source Type: research
Phytochemical profiling, antioxidant, cytotoxic, and anti-inflammatory activities of Plectranthus rugosus extract and fractions: in vitro, in vivo, and in silico approaches
ConclusionThe pro-inflammatory cytokines are inhibited byP. rugosus extracts, as well as an isolated compound oleanolic acid without compromising cell viability. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 3, 2024 Category: Drugs & Pharmacology Source Type: research
Observational analysis of the immunogenicity and safety of various types of spinal muscular atrophy vaccines
ConclusionThese findings indicated that both the oral vaccine and inactivated vaccine had good safety and immunogenicity in infants aged ≥ 2 months. The sIPV group generated higher levels of neutralizing antibodies in serum, particularly evident in the post-immunization GMT levels for types II and III. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 3, 2024 Category: Drugs & Pharmacology Source Type: research
Quercetin attenuates Pseudomonas aeruginosa-induced acute lung inflammation by inhibiting PI3K/AKT/NF- κB signaling pathway
In this study, we exploited network pharmacology- and molecular docking-based approach to explore the potential mechanisms of quercetin againstP. aeruginosa pneumonia, which was further validated via in vivo and in vitro experiments. The in vivo experiments demonstrated that quercetin alleviated theP. aeruginosa-induced lung injury by diminishing neutrophil infiltration and production of proinflammatory cytokines (IL-1 β, IL-6, and TNF), which was associated with decreased mortality. Moreover, the quercetin-treated mice displayed decreased phosphorylation levels of PI3K, AKT, IκBα, and NF-κB p65 in lung tissues compare...
Source: Inflammopharmacology - February 3, 2024 Category: Drugs & Pharmacology Source Type: research
Neuroprotective mechanism of trans,trans-Farnesol in an ICV-STZ-induced rat model of Alzheimer ’s pathology
ConclusionThe current work demonstrates the neuroprotective ability of TF in an experimental model with AD-like pathologies. The study further suggests that the neuroprotective impacts of TF may be related to its effects on TNF- α levels, oxidative stress pathways, and mitochondrial complex capabilities. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 3, 2024 Category: Drugs & Pharmacology Source Type: research
