Sesamol defends neuronal damage following cerebral ischemia/reperfusion: a crosstalk of autophagy and Notch1/NLRP3 inflammasome signaling
ConclusionsOur results revealed the neuroprotective effect of SES against cerebral I/R injury through alleviating injurious events and boosting autophagy, consequently abolishing Notch1/NLRP3 inflammasome signaling. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 17, 2023 Category: Drugs & Pharmacology Source Type: research
Protective effect of olopatadine hydrochloride against LPS-induced acute lung injury: via targeting NF- κB signaling pathway
ConclusionIn nutshell, inhibition of NF- κB pathway by Olo resulted in protection and reduced mortality in LPS- induced ALI and thus has potential to be used clinically to arrest disease progression in ALI/ARDS, since the drug is already in the market. However, the findings warrant further extensive studies, and also future studies can be planned to elucidate its role in COVID-19-associated ARDS or cytokine storm. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 17, 2023 Category: Drugs & Pharmacology Source Type: research
Efficacy and safety of licorice (Glycyrrhiza glabra) in moderately ill patients with COVID-19: a randomized controlled trial
In this study, 60 patients with confirmed COVID-19 were randomly assigned in a 1:1 ratio to receive licorice (at a dose of 760 mg three times a day for seven days) or control groups. The primary outcomes were SPO2, body temperature, and respiratory rate (RR) after the end of the intervention. The findings indicated that SPO2, body temperature, and RR had no significant difference between the groups at the end of the intervention. However, CRP and ALT improved in the licorice group toward the baseline. The number of patients with worse prognoses, LOS, mortality, and the incidence of adverse events were not different betwe...
Source: Inflammopharmacology - October 17, 2023 Category: Drugs & Pharmacology Source Type: research
Systems pharmacology and multi-scale mechanism of Enicostema axillare bioactives in treating Alzheimer disease
This study not only helps in understanding the molecular mechanism of the drugs but al so helps in finding and sorting new drugs for the treatment of AD, and other complex diseases through modern medicine. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 16, 2023 Category: Drugs & Pharmacology Source Type: research
A narrative review of the effects of dexamethasone on traumatic brain injury in clinical and animal studies: focusing on inflammation
AbstractTraumatic brain injury (TBI) is a type of brain injury resulting from a sudden physical force to the head. TBI can range from mild, such as a concussion, to severe, which might result in long-term complications or even death. The initial impact or primary injury to the brain is followed by neuroinflammation, excitotoxicity, and oxidative stress, which are the hallmarks of the secondary injury phase, that can further damage the brain tissue. Dexamethasone (DXM) has neuroprotective effects. It reduces neuroinflammation, a critical factor in secondary injury-associated neuronal damage. DXM can also suppress the microg...
Source: Inflammopharmacology - October 16, 2023 Category: Drugs & Pharmacology Source Type: research
The efficacy of thymosin alpha-1 therapy in moderate to critical COVID-19 patients: a systematic review, meta-analysis, and meta-regression
ConclusionOur study suggests that treatment with thymosin alpha-1 may reduce mortality rate in moderate to critical COVID-19 patients. Randomized clinical trials (RCTs) are still required to verify the findings of our study. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 16, 2023 Category: Drugs & Pharmacology Source Type: research
Pro-resolving and anti-inflammatory effects of resolvins and protectins in rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is typified by persistent joint inflammation, which leads to the deterioration of bone and cartilage and a reduction in overall quality of life. The global prevalence of pain as a primary symptom in RA is influenced by the interplay between inflammation and its resolution. The identification of a family of lipid mediators known as specialized pro-resolving mediators (SPM)s has contributed to the progress of our comprehension of inflammatory conditions. SPMs have been observed to trigger the process of inflammation resolution, thereby reinstating the homeostasis of the inflammatory response...
Source: Inflammopharmacology - October 13, 2023 Category: Drugs & Pharmacology Source Type: research
Cytokine profiles in COVID-19 patients undergoing adjunct ozone therapy: some comments
AbstractA comment to: Ghaleh HEG, Izadi M, Javanbakht M, Ghanei M, Einollahi B, Jafari NJ, Alishiri G, Aslani J, Abolghasemi H, Simonetti V, Khafaei M, Zhao S, Saadat SH, Ahmadi M, Parvin S, Vazifedoust S, Alvanagh AG. Cytokine profile and antioxidants status in the moderate and severe COVID-19 patients: a trial of ozone therapy impact as a medicinal supplement. Inflammopharmacology. 2023 Jul 12.https://doi.org/10.1007/s10787-023-01288-9. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 13, 2023 Category: Drugs & Pharmacology Source Type: research
Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice
In conclusion, this study sheds light on the potential therapeutic applications of the gel formulation containing essential oil fromP. glaziovianum in the context of wound healing. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 12, 2023 Category: Drugs & Pharmacology Source Type: research
1,4-Diaryl-1,2,3-triazole neolignan –celecoxib hybrids inhibit experimental arthritis induced by zymosan
AbstractRheumatoid arthritis (RA) is a chronic autoimmune disease that causes cartilage damage. Anti-inflammatories are widely used in the management of RA, but they can have side effects such as gastrointestinal and/or cardiovascular disorders. Studies published by our group showed that the synthesis of hybrid triazole analogs neolignan –celecoxib containing the substituent groups sulfonamide (L15) or carboxylic acid (L18) exhibited anti-inflammatory activity in an acute model of inflammation, inhibited expression of P-selectin related to platelet activation and did not induce gastric ulcer, minimizing the related side ...
Source: Inflammopharmacology - October 8, 2023 Category: Drugs & Pharmacology Source Type: research
Purinergic signaling: decoding its role in COVID-19 pathogenesis and promising treatment strategies
AbstractThe pathogenesis of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS ‑CoV‑2), is complex and involves dysregulated immune responses, inflammation, and coagulopathy. Purinergic signaling, mediated by extracellular nucleotides and nucleosides, has emerged as a significant player in the pathogenesis of COVID-19. Extracellular adenosine triphosphate (ATP), released f rom damaged or infected cells, is a danger signal triggering immune responses. It activates immune cells, releasing pro-inflammatory cytokines, contributing to the cytokine storm observed in severe COVID-1...
Source: Inflammopharmacology - October 8, 2023 Category: Drugs & Pharmacology Source Type: research
Reactive arthritis: the convoluted history of Reiter's disease
AbstractReactive arthritis, previously known as Reiter ’s Syndrome or Disease was a post-dysenteric, asymmetrical acute large joint polyarthritis, with fever, conjunctivitis, iritis, purulent urethral discharge, rash and penile soft tissue swelling. Although the eponym was given to Hans Reiter, various forms of the condition have been recorded in hist ory a few hundred years before Reiter. Two French doctors, Noel Fiessinger (1881–1946) and Edgar Leroy (d. 1965), presented a paper at la Societe des Hopitaux-in Paris on the 8th December 1916 on dysentery in 80 soldiers on the Somme, and four of whom developed a"syn...
Source: Inflammopharmacology - October 7, 2023 Category: Drugs & Pharmacology Source Type: research
Systematic review and meta-analysis of anti-CD20 treatments in patients with COVID-19: an assessment of severe illness and mortality outcomes
ConclusionHealthcare practitioners should exercise caution when prescribing these anti-CD20 monoclonal antibodies during the COVID-19 pandemic to patients who are indicated for these agents, particularly those with underlying conditions like multiple sclerosis or rheumatoid arthritis. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 7, 2023 Category: Drugs & Pharmacology Source Type: research
Effects of Chaerophyllum macropodum Boiss. leaves essential oil in inflammatory and neuropathic pain: uncovering the possible mechanism of action
ConclusionThe CMEO exerts anti-nociceptive and anti-neuropathic activities via the modulation of NO-cGMP potassium channel pathway, opioid as well as several non-opioid receptor activity. TP might partly contribute to the observed activities of CMEO.Graphical abstract (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 4, 2023 Category: Drugs & Pharmacology Source Type: research
Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
AbstractRecent studies have shown that, coupled with other environmental factors, aluminium exposure may lead to neurodegeneration resulting in cognitive impairment resembling Alzheimer's disease. Menaquinone, a form of vitamin K2, aids in maintaining healthy bones and avoids coronary calcification. It also has anti-inflammatory and antioxidant properties. Here, we study the neuroprotective effects of vitamin K2 (MK-7) using the animal model of Alzheimer's disease (AD). Aluminium chloride (AlCl3; 100 mg/kg for 3 weeks orally) was administered to Swiss albino mice to induce neurodegeneration and Vitamin K2 (100 g/kg for...
Source: Inflammopharmacology - September 26, 2023 Category: Drugs & Pharmacology Source Type: research
