What is the role of brown adipose tissue in metabolic health: lessons learned and future perspectives in the long COVID?
AbstractMetabolic physiology plays a key role in maintaining our health and resilience. Metabolic disorders can lead to serious illnesses, including obesity. The pathogenesis of the new long COVID syndrome in individuals with long-term recovery after SARS-Co-2 infection is still incomplete. Thus there is growing attention in the study of adipose tissue activities, especially brown adipose tissue (BAT) and associated resilience which plays a crucial role in different types of obesity as potential targets for pharmacologic and nutritional interventions in the context of obesity and long COVID. The number of studies examining...
Source: Inflammopharmacology - March 25, 2023 Category: Drugs & Pharmacology Source Type: research
What is really ‘Long COVID’?
AbstractThe previous acute respiratory diseases caused by viruses originating from China or the middle east (e.g., SARS, MERS) remained fast developing short diseases without major sequalae or any long-lasting complications. The new COVID-19, on the other hand, not only that it rapidly spread over the world, but some patients never fully recovered or even if they did, a few weeks later started to complain not only of shortness of breath, if any, but general weakness, muscle pains and ‘brain fog’, i.e., fuzzy memories. Thus, these signs and symptoms were eventually labelled ‘long COVID’, for which the most widely us...
Source: Inflammopharmacology - March 25, 2023 Category: Drugs & Pharmacology Source Type: research
A story of the potential effect of non-steroidal anti-inflammatory drugs (NSAIDs) in Parkinson ’s disease: beneficial or detrimental effects
In conclusion, there is still a potential conflict regarding the effect of NSAIDs on PD neuropathology. (Source: Inflammopharmacology)
Source: Inflammopharmacology - March 24, 2023 Category: Drugs & Pharmacology Source Type: research
Post-COVID interstitial lung disease in symptomatic patients after COVID-19 disease
AbstractCOVID-19 is often associated with long-lasting pulmonary symptoms. Data are scarce about interstitial lung disease (ILD) in patients following COVID-19 hospitalization with persistent symptoms. We retrospectively reviewed all cases sent to pulmonary post-COVID evaluation due to persistent symptoms between February 2021 and February 2022 (N = 318). All patients with suspected ILD (N = 44) were reviewed at the multidisciplinary discussion. Patient characteristics, symptoms, time since hospitalization, detailed lung function measurements and 6-min walk test (6MWT) were evaluated. The post-COVID ILD suspected ...
Source: Inflammopharmacology - March 24, 2023 Category: Drugs & Pharmacology Source Type: research
Brain insulin resistance linked Alzheimer ’s and Parkinson’s disease pathology: An undying implication of epigenetic and autophagy modulation
Abstract
In metabolic syndrome, dysregulated signalling activity of the insulin receptor pathway in the brain due to persistent insulin resistance (IR) condition in the periphery may lead to brain IR (BIR) development. BIR causes an upsurge in the activity of glycogen synthase kinase-3 beta, increased amyloid beta (A β) accumulation, hyperphosphorylation of tau, aggravated formation of Aβ oligomers and simultaneously neurofibrillary tangle formation, all of which are believed to be direct contributors in Alzheimer’s Disease (AD) pathology. Likewise, for Parkinson’s Disease (PD), BIR is associated with alph a-synuc...
Source: Inflammopharmacology - March 23, 2023 Category: Drugs & Pharmacology Source Type: research
Long COVID prevalence and physiology-centered risks: population-based study in Ukraine
ConclusionsThe prevalence of long COVID is 23%, and its physiology-centered risk factors are related to age more 38 years, female sex, unhealthy lifestyle, increased BMI, and increased inflammatory markers during COVID-19. The most common symptoms are associated with neurocognitive and pain clusters. (Source: Inflammopharmacology)
Source: Inflammopharmacology - March 22, 2023 Category: Drugs & Pharmacology Source Type: research
Liquiritigenin, isoliquiritigenin rich extract of glycyrrhiza glabra roots attenuates inflammation in macrophages and collagen-induced arthritis in rats
AbstractLiquiritigenin (LTG) and its bioprecursor isoliquiritigenin(ISL), the main bioactives from roots of Glycyrrhiza genus are progressively documented as a potential pharmacological agent for the management of chronic diseases. The aim of this study was to evaluate the pharmacological potential of liquiritigenin, isoliquiritigenin rich extract ofGlycyrrhiza glabra roots (IVT-21) against the production of pro-inflammatory cytokines from activated macrophages as well as further validated the efficacy in collagen-induced arthritis model in rats. We also performed the safety profile ofIVT-21 using standardin-vitro andin-vi...
Source: Inflammopharmacology - March 22, 2023 Category: Drugs & Pharmacology Source Type: research
Bioactive fraction of Tragia involucrata Linn leaves attenuates inflammation in Freund ’s complete adjuvant-induced arthritis in Wistar albino rats via inhibiting NF-κB
AbstractTragia involucrata Linn. (T. involucrata) belongs to the family of Euphorbiaceae found in the subtropical regions. Traditionally, the plant parts are used to treat inflammation, wounds and skin infection by people of the Western Ghats, India. Few studies on the acute anti-inflammatory activity ofT. involucrata extracts were reported earlier. The present study aims to identify the bioactive fraction ofT. involucrata and to evaluate its mechanism in Complete Freund ’s Adjuvant-induced arthritic rat model. The leaf extract was highly effective among the methanolic leaf and root extracts. The hexane (HF) and a methan...
Source: Inflammopharmacology - March 22, 2023 Category: Drugs & Pharmacology Source Type: research
Suppressing NLRP3 activation and PI3K/AKT/mTOR signaling ameliorates amiodarone-induced pulmonary fibrosis in rats: a possible protective role of nobiletin
AbstractAmiodarone (AMD), a medicine used to treat life-threatening arrhythmias, is frequently linked to pulmonary fibrosis (PF). Despite the involvement of NLRP3 inflammasome and PI3K/Akt/mTOR axis in fibrosis modulation and development, their significance in the etiology of AMD-induced PF remains uncertain. Nobiletin (NOB), a citrus flavonoid, has recently gained attention for its ability to reduce fibrotic processes in a variety of organs through inhibiting NLRP3-associated inflammation and suppressing PI3K/AKT/mTOR fibrotic pathway. Therefore, this research aimed to investigate the possible beneficial impact of NOB aga...
Source: Inflammopharmacology - March 22, 2023 Category: Drugs & Pharmacology Source Type: research
Correction to: Association between metabolic associated fatty liver disease and osteoarthritis using data from the Korean national health and nutrition examination survey (KNHANES)
(Source: Inflammopharmacology)
Source: Inflammopharmacology - March 22, 2023 Category: Drugs & Pharmacology Source Type: research
What is the role of brown adipose tissue in metabolic health: lessons learned and future perspectives in the long COVID?
AbstractMetabolic physiology plays a key role in maintaining our health and resilience. Metabolic disorders can lead to serious illnesses, including obesity. The pathogenesis of the new long COVID syndrome in individuals with long-term recovery after SARS-Co-2 infection is still incomplete. Thus there is growing attention in the study of adipose tissue activities, especially brown adipose tissue (BAT) and associated resilience which plays a crucial role in different types of obesity as potential targets for pharmacologic and nutritional interventions in the context of obesity and long COVID. The number of studies examining...
Source: Inflammopharmacology - March 21, 2023 Category: Drugs & Pharmacology Source Type: research
Isostearic acid is an active component of imiquimod formulations used to induce psoriaform disease models
AbstractTopical imiquimod based creams are indicated as immune stimulants for papillomas and various skin neoplasms. Imiquimod is considered a TLR7 ligand. These creams are also used in research to induce skin inflammation in mice as a model for psoriasis. We observed that this inflammatory response was not strictly imiquimod dependent and we set out to establish which components drive the proinflammatory effects. To this end, we examined the induction response in a BALB/cJRj mouse model, in which 50 mg of cream is applied to 2 cm2 of skin (125 mg/kg imiquimod—5% W/V, and/or 625 mg/kg isostearic acid—25% W/V). Com...
Source: Inflammopharmacology - March 21, 2023 Category: Drugs & Pharmacology Source Type: research
Antioxidants: an approach for restricting oxidative stress induced neurodegeneration in Alzheimer ’s disease
AbstractAlzheimer ’s disease (AD) is the leading cause of dementia, affecting millions of people worldwide. Oxidative stress contributes towards induction of neurodegeneration. It is one of the reasons behind initiation and progression of Alzheimer ’s disease. Understanding of oxidative balance and restoration of oxidative stress has demonstrated its effectiveness in the management of AD. Various natural and synthetic molecules have been found to be effective in different models of AD. Some clinical studies also support the use of antioxidan ts for prevention of neurodegeneration in AD. In this review we are summarizin...
Source: Inflammopharmacology - March 18, 2023 Category: Drugs & Pharmacology Source Type: research
Real-world practice of the Egyptian Kelleni ’s protocol amid changing tropism of SARS-CoV-2 omicron BA.5.2.1.7, XBB 1.5 and CH.1.1 subvariants: a multi-purpose protocol
AbstractThe Egyptian immune-modulatory Kelleni ’s protocol, including nitazoxanide as an integral component, is being safely and effectively practiced to manage SARS-CoV-2, RSV, influenza infections in pediatric, adult and pregnant patients with negligible requirements for the relatively expensive diagnostic molecular tests. Most recently, Kel leni’s protocol is being likewise used to manage potential norovirus infection which is currently confused with SARS-CoV-2 Omicron new enterotropic subvariants and the antihistaminic loratadine has been co-administered in selected patients. Notably, Africa has the least mandates,...
Source: Inflammopharmacology - March 16, 2023 Category: Drugs & Pharmacology Source Type: research
Nutritional deficiencies that may predispose to long COVID
AbstractMultiple nutritional deficiencies (MND) confound studies designed to assess the role of a single nutrient in contributing to the initiation and progression of disease states. Despite the perception of many healthcare practitioners, up to 25% of Americans are deficient in five-or-more essential nutrients. Stress associated with the COVID-19 pandemic further increases the prevalence of deficiency states. Viral infections compete for crucial nutrients with immune cells. Viral replication and proliferation of immunocompetent cells critical to the host response require these essential nutrients, including zinc. Clinical...
Source: Inflammopharmacology - March 15, 2023 Category: Drugs & Pharmacology Source Type: research
