Appraisal of anti-arthritic potential of Coronopus didymus (L.) Sm. aqueous extract and its safety study in Wistar rats
AbstractThe current study aimed to find out the anti-arthritic activity and safety study ofCoronopus didymus aqueous extract (CDAE) as well as its chemical characterization by HPLC –DAD. Safety study including acute and subacute toxicity studies of the plant aqueous extract was also performed. In complete Freund’s adjuvant-induced arthritic model (CFA), 0.15 ml CFA was injected in the left hind paw at day 1 in all rats except normal rats. Treatment with CDAE at 200, 400, and 800 mg/kg and methotrexate (1 mg/kg) was administered at day 8 and continued till 28th day using oral gavage. The CDAE considerably (p < â...
Source: Inflammopharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes
AbstractTen sesquiterpene lactones isolated fromAnvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3 α,4α-10β-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1),epi-vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinamine D (8), garcinamine E (9), and 4, 9-dihydroxyguaian-10(14)-en-12-olide (10) showed explicit anti-inflammatory activity in rodent paw edema and MPO assignment. The findings of this study showed that the α-methylene γ-lactone moiety does not always guarantee an anti-i...
Source: Inflammopharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research
Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy
In conclusion, evidence has been significantly strengthene d over the past 18Â months, with several meta-analyses and RCTs reporting conclusive beneficial effects of VD supplementation against COVID-19 and highlighting metformin to improve VDR sensitivity and efficacy in treating COVID-19 and long COVID-19. (Source: Inflammopharmacology)
Source: Inflammopharmacology - November 13, 2023 Category: Drugs & Pharmacology Source Type: research
A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications
AbstractSulforaphane (SFN) is a type of phytochemical found in many cruciferous vegetables that has been shown to positively benefit the control of Type 2 Diabetes Mellitus (T2DM). The search was done from 2000 until December 2022 using PubMed, Scopus, Web of Sciences, and Google Scholar databases. We included all in vitro,in vivo, and clinical trials. Sulforaphane has been demonstrated to activate the PI3K/AKT and AMP-activated protein kinase pathways and the glucose transporter type 4 to increase insulin production and reduce insulin resistance. Interestingly, SFN possesses protective effects against diabetes complicatio...
Source: Inflammopharmacology - November 13, 2023 Category: Drugs & Pharmacology Source Type: research
Topical Nigella sativa L. product: a new candidate for the management of diabetic peripheral neuropathy
ConclusionAccording to the results of this study, the topical use ofN. sativa, compared to the current drugs, has acceptable improving effects on diabetic neuropathic patients. (Source: Inflammopharmacology)
Source: Inflammopharmacology - November 13, 2023 Category: Drugs & Pharmacology Source Type: research
Curcuminoids-enriched extract and its cyclodextrin inclusion complexes ameliorates arthritis in complete Freund ’s adjuvant-induced arthritic mice via modulation of inflammatory biomarkers and suppression of oxidative stress markers
AbstractCurcuma longa extract and its marker curcuminoids have potential use in inflammatory conditions. However, curcuminoids solubility and bioavailability are major hindrances to their bioactivity. The current study investigated green extraction-based curcuminoids-enriched extract (CRE) prepared fromC. longa and its cyclodextrin inclusion complexes, i.e., binary inclusion complexes (BC) and ternary inclusion complexes (TC), in complete Freund ’s adjuvant (CFA)-induced mice for their comparative anti-arthritic efficacy. CRE, BC, and TC (2.5 and 5 mg/kg) with the standard drug diclofenac sodium (13.5 mg/kg) were orall...
Source: Inflammopharmacology - November 13, 2023 Category: Drugs & Pharmacology Source Type: research
Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives
AbstractChronic inflammation is a common underlying factor in many major diseases, including heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to 60% of all deaths worldwide. Metformin, statins, and corticosteroids, and NSAIDs (non-steroidal anti-inflammatory drugs) are often given as anti-inflammatory pharmaceuticals, however, often have even more debilitating side effects than the illness itself. The natural product-based therapy of inflammation-related diseases has no adverse effects and good beneficial results compared to substitute conventional anti-inflammatory medications. In this ...
Source: Inflammopharmacology - November 11, 2023 Category: Drugs & Pharmacology Source Type: research
Dietary tannic acid attenuates elastase-induced pulmonary inflammation and emphysema in mice
AbstractEmphysema is one of the major components of chronic obstructive pulmonary disease (COPD), which is characterised by the destruction and enlargement of air spaces, leading to airflow limitation and dyspnoea, finally progressing to oxygen dependency. The alveolar wall destruction is due to chronic inflammation, oxidative stress, apoptosis, and proteinase/anti-proteinase imbalance. So far, there has been no effective therapy for patients with COPD. We evaluated the therapeutic efficacy of tannic acid (TA), a naturally occurring plant-derived polyphenol in the murine emphysema model. In C57BL/6 Â J mice, we established...
Source: Inflammopharmacology - November 10, 2023 Category: Drugs & Pharmacology Source Type: research
Recent advances in anti-inflammatory active components and action mechanisms of natural medicines
AbstractInflammation is a series of reactions caused by the body ’s resistance to external biological stimuli. Inflammation affects the occurrence and development of many diseases. Anti-inflammatory drugs have been used widely to treat inflammatory diseases, but long-term use can cause toxic side-effects and affect human functions. As immunomodulators with long -term conditioning effects and no drug residues, natural products are being investigated increasingly for the treatment of inflammatory diseases. In this review, we focus on the inflammatory process and cellular mechanisms in the development of diseases such as in...
Source: Inflammopharmacology - November 10, 2023 Category: Drugs & Pharmacology Source Type: research
Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI –MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model
AbstractPersea americana Mill. (avocado fruit) has many health benefits when added to our diet due to various pharmacological activities, such as preventing bone loss and inflammation, modulating immune response and acting as an antioxidant. In the current study, the total ethanol extract (TEE) of the fruit was investigated for in vitro antioxidant and anti-inflammatory activity via DPPH and cyclooxygenase enzyme inhibition. Biological evaluation of the antiarthritic effect of the fruit extract was further investigated in vivo using Complete Freund ’s Adjuvant (CFA) arthritis model, where the average percentages of body ...
Source: Inflammopharmacology - November 7, 2023 Category: Drugs & Pharmacology Source Type: research
Curcumin and PCI-34051 combined treatment ameliorates inflammation and fibrosis by affecting MAP kinase pathway
ConclusionsPresent study indicates protective effects of HDAC8 inhibition in asthma using HDAC8 using CUR and PCI alone or in combination, attenuates airway inflammation, fibrosis and remodeling; hence, bronchoconstriction was accompanied through modulation of MAP kinase pathway. (Source: Inflammopharmacology)
Source: Inflammopharmacology - November 7, 2023 Category: Drugs & Pharmacology Source Type: research
Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches
AbstractAcetylsalicylic acid (ASA), also known as aspirin, was discovered in 1897 as an acetylated form of salicylate. It has been widely used for its anti-inflammatory and antiplatelet effects. It is commonly used for its cardiovascular benefits and is prescribed as secondary prophylaxis after a heart attack. Furthermore, low-dose, long-term ASA is used to reduce the risk of heart attack and stroke in individuals without prior cardiovascular disease. Acetylsalicylic acid acts as a non-selective inhibitor of cyclooxygenase (COX), which inhibits the synthesis of prostaglandins and prevents pro-inflammatory cytokines. Findin...
Source: Inflammopharmacology - November 4, 2023 Category: Drugs & Pharmacology Source Type: research
Effect of nitro-conjugated linoleic acid on the inflammatory response of murine macrophages activated with lipopolysaccharide derived from Prevotella intermedia
AbstractNitro-conjugated linoleic acid (NO2-CLA) has been observed to manifest salutary signaling responses, including anti-inflammatory and antioxidant properties. Here, the authors have explored the influence and underlying mechanisms of NO2-CLA on the proinflammatory reaction of murine macrophages that were challenged with lipopolysaccharide (LPS) derived fromPrevotella intermedia, a putative periodontopathic bacterium. Treatment of LPS-activated RAW264.7 cells with NO2-CLA notably dampened the secretion of iNOS-derived NO, IL-1 β and IL-6 as well as their gene expressions and significantly enhanced the markers for M2 ...
Source: Inflammopharmacology - November 3, 2023 Category: Drugs & Pharmacology Source Type: research
Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer
AbstractGastric ulcer is a chronic  disease that affects about 10% of the world’s population. This disease is caused by factors such as stress, smoking, alcohol consumption, nonsteroidal anti-inflammatory drugs (NSAIDs),Helicobacter pylori infection, and genetic factors. Herbal medicines such as plant extracts are new sources of drugs with promising results in treating gastric ulcers. Nanotechnology and nanomedicine have been able to reach this objective to some extent. Green synthesis is an alternative method adapted for chemical and physical methods. In the last few years, fungi, bacteria, viruses, algae, and plants h...
Source: Inflammopharmacology - November 3, 2023 Category: Drugs & Pharmacology Source Type: research
Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification
AbstractThe inflammatory response in ulcerative colitis (UC) could be relieved by the conventional immunomodulatory agents; 5-aminosalicylic acid, corticosteroids, or azathioprine. However, the low remission rates and the intolerance to these agents necessitate investigation of gene expression signature in UC that could influence the therapeutic efficacy of drugs, as well as the interference with persistence genes by novel therapeutic option. Three microarray datasets (GSE66407, GSE38713 and GSE14580) from the NCBI-GEO database were utilized. Differentially expressed genes between samples of patients with UC and healthy on...
Source: Inflammopharmacology - October 30, 2023 Category: Drugs & Pharmacology Source Type: research
