Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives
AbstractChronic inflammation is a common underlying factor in many major diseases, including heart disease, diabetes, cancer, and autoimmune disorders, and is responsible for up to 60% of all deaths worldwide. Metformin, statins, and corticosteroids, and NSAIDs (non-steroidal anti-inflammatory drugs) are often given as anti-inflammatory pharmaceuticals, however, often have even more debilitating side effects than the illness itself. The natural product-based therapy of inflammation-related diseases has no adverse effects and good beneficial results compared to substitute conventional anti-inflammatory medications. In this ...
Source: Inflammopharmacology - November 11, 2023 Category: Drugs & Pharmacology Source Type: research
Dietary tannic acid attenuates elastase-induced pulmonary inflammation and emphysema in mice
AbstractEmphysema is one of the major components of chronic obstructive pulmonary disease (COPD), which is characterised by the destruction and enlargement of air spaces, leading to airflow limitation and dyspnoea, finally progressing to oxygen dependency. The alveolar wall destruction is due to chronic inflammation, oxidative stress, apoptosis, and proteinase/anti-proteinase imbalance. So far, there has been no effective therapy for patients with COPD. We evaluated the therapeutic efficacy of tannic acid (TA), a naturally occurring plant-derived polyphenol in the murine emphysema model. In C57BL/6 J mice, we established...
Source: Inflammopharmacology - November 10, 2023 Category: Drugs & Pharmacology Source Type: research
Recent advances in anti-inflammatory active components and action mechanisms of natural medicines
AbstractInflammation is a series of reactions caused by the body ’s resistance to external biological stimuli. Inflammation affects the occurrence and development of many diseases. Anti-inflammatory drugs have been used widely to treat inflammatory diseases, but long-term use can cause toxic side-effects and affect human functions. As immunomodulators with long -term conditioning effects and no drug residues, natural products are being investigated increasingly for the treatment of inflammatory diseases. In this review, we focus on the inflammatory process and cellular mechanisms in the development of diseases such as in...
Source: Inflammopharmacology - November 10, 2023 Category: Drugs & Pharmacology Source Type: research
Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI –MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model
AbstractPersea americana Mill. (avocado fruit) has many health benefits when added to our diet due to various pharmacological activities, such as preventing bone loss and inflammation, modulating immune response and acting as an antioxidant. In the current study, the total ethanol extract (TEE) of the fruit was investigated for in vitro antioxidant and anti-inflammatory activity via DPPH and cyclooxygenase enzyme inhibition. Biological evaluation of the antiarthritic effect of the fruit extract was further investigated in vivo using Complete Freund ’s Adjuvant (CFA) arthritis model, where the average percentages of body ...
Source: Inflammopharmacology - November 7, 2023 Category: Drugs & Pharmacology Source Type: research
Curcumin and PCI-34051 combined treatment ameliorates inflammation and fibrosis by affecting MAP kinase pathway
ConclusionsPresent study indicates protective effects of HDAC8 inhibition in asthma using HDAC8 using CUR and PCI alone or in combination, attenuates airway inflammation, fibrosis and remodeling; hence, bronchoconstriction was accompanied through modulation of MAP kinase pathway. (Source: Inflammopharmacology)
Source: Inflammopharmacology - November 7, 2023 Category: Drugs & Pharmacology Source Type: research
Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches
AbstractAcetylsalicylic acid (ASA), also known as aspirin, was discovered in 1897 as an acetylated form of salicylate. It has been widely used for its anti-inflammatory and antiplatelet effects. It is commonly used for its cardiovascular benefits and is prescribed as secondary prophylaxis after a heart attack. Furthermore, low-dose, long-term ASA is used to reduce the risk of heart attack and stroke in individuals without prior cardiovascular disease. Acetylsalicylic acid acts as a non-selective inhibitor of cyclooxygenase (COX), which inhibits the synthesis of prostaglandins and prevents pro-inflammatory cytokines. Findin...
Source: Inflammopharmacology - November 4, 2023 Category: Drugs & Pharmacology Source Type: research
Effect of nitro-conjugated linoleic acid on the inflammatory response of murine macrophages activated with lipopolysaccharide derived from Prevotella intermedia
AbstractNitro-conjugated linoleic acid (NO2-CLA) has been observed to manifest salutary signaling responses, including anti-inflammatory and antioxidant properties. Here, the authors have explored the influence and underlying mechanisms of NO2-CLA on the proinflammatory reaction of murine macrophages that were challenged with lipopolysaccharide (LPS) derived fromPrevotella intermedia, a putative periodontopathic bacterium. Treatment of LPS-activated RAW264.7 cells with NO2-CLA notably dampened the secretion of iNOS-derived NO, IL-1 β and IL-6 as well as their gene expressions and significantly enhanced the markers for M2 ...
Source: Inflammopharmacology - November 3, 2023 Category: Drugs & Pharmacology Source Type: research
Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer
AbstractGastric ulcer is a chronic disease that affects about 10% of the world’s population. This disease is caused by factors such as stress, smoking, alcohol consumption, nonsteroidal anti-inflammatory drugs (NSAIDs),Helicobacter pylori infection, and genetic factors. Herbal medicines such as plant extracts are new sources of drugs with promising results in treating gastric ulcers. Nanotechnology and nanomedicine have been able to reach this objective to some extent. Green synthesis is an alternative method adapted for chemical and physical methods. In the last few years, fungi, bacteria, viruses, algae, and plants h...
Source: Inflammopharmacology - November 3, 2023 Category: Drugs & Pharmacology Source Type: research
Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification
AbstractThe inflammatory response in ulcerative colitis (UC) could be relieved by the conventional immunomodulatory agents; 5-aminosalicylic acid, corticosteroids, or azathioprine. However, the low remission rates and the intolerance to these agents necessitate investigation of gene expression signature in UC that could influence the therapeutic efficacy of drugs, as well as the interference with persistence genes by novel therapeutic option. Three microarray datasets (GSE66407, GSE38713 and GSE14580) from the NCBI-GEO database were utilized. Differentially expressed genes between samples of patients with UC and healthy on...
Source: Inflammopharmacology - October 30, 2023 Category: Drugs & Pharmacology Source Type: research
Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases
AbstractGastrointestinal (GI) diseases have become a global health issue and an economic burden due to their wide distribution, late prognosis, and the inefficacy of recent available medications. Therefore, it is crucial to search for new strategies for their management. In the recent decades, mesenchymal stem cells (MSCs) therapy has attracted attention as a viable option for treating a myriad of GI disorders such as hepatic fibrosis (HF), ulcerative colitis (UC), acute liver injury (ALI), and non-alcoholic fatty liver disease (NAFLD) due to their regenerative and paracrine properties. Importantly, recent studies have sho...
Source: Inflammopharmacology - October 24, 2023 Category: Drugs & Pharmacology Source Type: research
2-Hydroxybenzohydrazide as a novel potential candidate against nociception, inflammation, and pyrexia: in vitro, in vivo, and computational approaches
AbstractThe current study was designed to evaluate the 2-hydroxybenzohydrazide (HBH) as a drug having efficacy against pyrexia, inflammation, and nociception. Besides, the therapeutic effects of HBH on oxidative stress and C-reactive proteins were also evaluated. The pharmacological studies on HBH (20 –60 mg/kg) were conducted using nociception, inflammation, and pyrexia standard models. Naloxone antagonism was performed to assess the possible involvement of opioidergic mechanisms. The antioxidant study was conducted on ABTS and DPPH assays using gallic acid as a standard. Moreover, the bindin g capability of HBH with e...
Source: Inflammopharmacology - October 21, 2023 Category: Drugs & Pharmacology Source Type: research
Attenuation of CFA-induced arthritis through regulation of inflammatory cytokines and antioxidant mechanisms by Solanum nigrum L. leaves extracts
AbstractSolanum nigrum L. is a popular traditional medicine for various inflammatory conditions including rheumatism and joint pain. The current study aimed to evaluate the anti-arthritic mechanism ofSolanum nigrum L. Four extracts were prepared using n-hexane, methanol, chloroform, and water. The anti-nociceptive and anti-inflammatory activity was carried out with 100, 200, and 300 mg/kg body wt. PO of each extract by the hot plate and carrageenan-induced paw oedema methods, respectively. The anti-arthritic study was performed with chloroform and aqueous extracts (300 mg/kg) in complete Freund’s adjuvant (CFA)-induce...
Source: Inflammopharmacology - October 21, 2023 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory activity of peiminine in acetic acid-induced ulcerative colitis model
This study aims to investigate the anti-inflammatory effects of peiminine in an experimental model of ulcerative colitis. Ulcerative colitis was induced intra-rectally in all groups, except the negative control, using 100 μl of 4% acetic acid. Peiminine treatment was initiated after ulcerative colitis induction and symptom manifestation. After the final injection, mice were sacrificed on day 15 for assessment. Various parameters were evaluated, including disease activity index, myeloperoxidase activity, nitric oxide levels, production and expression of IL-1, IL-6, TNF-α cytokines, and expression of IL-1β, IL-6, TNF-α, ...
Source: Inflammopharmacology - October 19, 2023 Category: Drugs & Pharmacology Source Type: research
Potential role of SNP rs2071475 in rheumatoid arthritis and inflammatory bowel disease in the East Asian population: a Mendelian randomization study
ConclusionThis study revealed a potential increased susceptibility to CD and a decreased susceptibility to UC in the East Asian population with RA. Furthermore, a key SNP rs2071475 was discovered along with its opposite effects in CD and UC. These findings provide new evidence for research on the corresponding molecular mechanisms and offer insights for clinical management of RA-associated IBD. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 19, 2023 Category: Drugs & Pharmacology Source Type: research
The effect of probiotics on the risk of mortality in patients with COVID-19: systematic review and meta-analysis of randomized trials
In conclusion, evidence derived from randomized controlled trials (RCTs) indicates a survival benefit associated with the use of probiotics among COVID-19 patients. However, it is essential to exercise caution and await data from large-scale randomi zed trials to definitively confirm the mortality benefits of probiotics in this patient population. (Source: Inflammopharmacology)
Source: Inflammopharmacology - October 17, 2023 Category: Drugs & Pharmacology Source Type: research
