Intraarticular monomethyl fumarate as a perspective therapy for osteoarthritis by macrophage polarization
ConclusionsOur studies with EOA model induced by MIA suggest a new perspective for human treatment committed with OA based on macrophage polarization as a therapeutic target, switching the proinflammatory profile M1 to the anti-inflammatory profile M2 with DMF systematic or by MMF locally treatment according to the OA severity. (Source: Inflammopharmacology)
Source: Inflammopharmacology - March 13, 2024 Category: Drugs & Pharmacology Source Type: research
Antinociceptive and anti-inflammatory activity of extracts and α-pyrones isolated from Cantinoa stricta
This study evaluated the composition and the antinociceptive and anti-inflammatory activity of the crude extracts and two isolated compounds, anamarine (ANA) and 10-epi-olguine (eOL), obtained from the leaves ofCantinoa stricta (Lamiaceae). Crude ethanolic extract (EEt) and dichloromethane extract (DCM), selected based on NMR data, were submitted to pharmacological tests in male Swiss mice. The oral administration of EEt and DCM significantly reduced the second phase of formalin-induced nociception (60%), lipopolysaccharide (LPS)-induced mechanical hyperalgesia (90%), and carrageenan (Cg)-induced edema (25%). ANA and eOL, ...
Source: Inflammopharmacology - March 11, 2024 Category: Drugs & Pharmacology Source Type: research
Anti-rheumatoid arthritis potential of Halodule pinifolia: development, characterization and in vivo evaluation of H. pinifolia-based oral suspension and lipid nano-emulsion
In this study, the anti-rheumatoid arthritis effect of an unexplored marine grassHalodule pinifolia (HP), and a combination of it withGlycyrrhiza glabra (liquorice; LQ), prepared as a conventional suspension (C1) and a lipid nano-emulsion (C1-N) was evaluated in Freund ’s complete adjuvant (FCA)- and collagen-induced arthritis (CIA) models. Formulations C1 and C1-N contained standardized extract HP (100 mg/kg) as major active ingredient and liquorice LQ (50 mg/kg) as both active ingredient (anti-inflammatory and anti-ulcer) and sweetening agent. Oral administr ation of HP and C1 to FCA-induced Sprague–Dawley rats sig...
Source: Inflammopharmacology - March 7, 2024 Category: Drugs & Pharmacology Source Type: research
Celecoxib attenuates hindlimb unloading-induced muscle atrophy via suppressing inflammation, oxidative stress and ER stress by inhibiting STAT3
This study is the first to demonstrate that celecoxib can attenuate disuse muscle atrophy caused by hindlimb unloading via suppressing inflammation, oxidative stress and endoplasmic reticulum stress probably, improving target muscle function and reversing the shift of muscle fiber types by inhibiting STAT3 pathways-mediated inflammatory cascade. This study not only enriches the potential molecular regulatory mechanisms, but also provides new potential therapeutic targets for disuse muscle atrophy. (Source: Inflammopharmacology)
Source: Inflammopharmacology - March 7, 2024 Category: Drugs & Pharmacology Source Type: research
3-Acetyl coumarin alleviate neuroinflammatory responses and oxidative stress in aluminum chloride-induced Alzheimer ’s disease rat model
The objective of the present investigation was to assess the effect 3-acetyl coumarin (3AC) in a rat model of AD. Preliminary screening was performed with SWISS ADME to check for the bioavailability of 3-AC and likeness score which proved favorable. 3-AC docked a gainst Caspase 3, NF-κβ and tau protein kinase I exhibited good binding energies. Male rats were divided into six groups (n = 5). AlCl3 (100 mg/kg BW) was administered for 28 days before starting treatment to induce AD. Normal control rats received vehicle. Treatment groups received 10, 20 and 30 mg/kg 3-AC for 28 days. Rivastigmine (2 mg/kg) was the s...
Source: Inflammopharmacology - March 6, 2024 Category: Drugs & Pharmacology Source Type: research
Sinomenine protects against atherosclerosis in apolipoprotein E-knockout mice by inhibiting of inflammatory pathway
AbstractAtherosclerosis, a multifaceted and persistent inflammatory condition, significantly contributes to the progression of cardiocerebrovascular disorders, such as myocardial infarctions and cerebrovascular accidents. It involves the accumulation of cholesterol, fatty deposits, calcium and cellular debris in the walls of arteries, leading to the formation of plaques. Our aim is to investigate the potential of sinomenine to counteract atherosclerosis in mice lacking Apolipoprotein E (ApoE −/−) Mice. We employed the high-fat diet-induced method to induce atherosclerosis in ApoE−/− mice, and the mice were treated ...
Source: Inflammopharmacology - March 2, 2024 Category: Drugs & Pharmacology Source Type: research
Pterostilbene: a potential therapeutic agent for fibrotic diseases
AbstractFibrosis is a prevailing pathology in chronic diseases and accounts for 45% of deaths in developed countries. This condition is primarily identified by the transformation of fibroblasts into myofibroblasts and the overproduction of extracellular matrix (ECM) by myofibroblasts. Pterostilbene (PTS) is a natural analogue of resveratrol and is most commonly found in blueberries. Research has shown that PTS exerts a wide range of pharmacological effects, such as antioxidant, anti-inflammatory, and anticancer effects. As a result, PTS has the potential to prevent and cure numerous diseases. Emerging evidence has indicate...
Source: Inflammopharmacology - March 1, 2024 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory and anti-arthritic potential of Coagulansin-A: in vitro and in vivo studies
AbstractThe current work was designed to evaluate the anti-inflammatory and anti-arthritic potential of Coagulansin-A (Coag-A) using mouse macrophages and arthritic mice. In the LPS-induced RAW 264.7 cells, the effects of Coag-A on the release of nitric oxide (NO), reactive oxygen species (ROS), and pro-inflammatory cytokines were analyzed. In addition, the mediators involved in the nuclear factor-kappa B (NF- κB) and nuclear factor erythroid 2-related factor 2 (Nrf2) pathways were evaluated by the RT-qPCR and western blotting. Coag-A did not show significant cytotoxicity in the RAW 264.7 cells in the tested concentration...
Source: Inflammopharmacology - February 27, 2024 Category: Drugs & Pharmacology Source Type: research
Sulfasalazine promotes ferroptosis through AKT-ERK1/2 and P53-SLC7A11 in rheumatoid arthritis
ConclusionsSulfasalazine promoted ferroptosis of FLSs in rheumatoid arthritis, and the PI3K-AKT-ERK1/2 pathway and P53-SLC7A11 pathway play an important role in this process. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 26, 2024 Category: Drugs & Pharmacology Source Type: research
The effects of silymarin consumption on inflammation and oxidative stress in adults: a systematic review and meta-analysis
ConclusionsSilymarin can help reduce inflammation in patients with diabetes and thalassemia by reducing MDA as an oxidative stress marker and CRP and IL-6 as inflammatory markers. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 19, 2024 Category: Drugs & Pharmacology Source Type: research
Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models
ConclusionGlabridin can significantly reduce or even reverse LPS-induced neuroinflammation, which may be related to the fact that glabridin can reduce the NO expression, NF- κB, IBA-1, GFAP, and other inflammatory mediators, upregulate the expression of SOD to relieve oxidative stress of brain and inhibit the activation of gliocyte in brain tissue. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 19, 2024 Category: Drugs & Pharmacology Source Type: research
Ameliorative effects of Atriplex crassifolia (C.A.Mey) on pain and inflammation through modulation of inflammatory biomarkers and GC –MS-based metabolite profiling
AbstractAtriplex crassifolia (A. crassifolia) is a locally occurring member of Chenopodiaceae family that has been used in folk medicine for the treatment of joint pain and inflammation. The present study was focused to determine the analgesic and anti-inflammatory potential of the plant. n-hexane (ACNH) and methanol (ACM) extracts ofA. crassifolia were evaluated for in vitro anti-inflammatory potential using protein denaturation inhibition assay. In vivo anti-inflammatory potential was determined by oral administration of 250, 500, and 1000 mg/kg/day of extracts against carrageenan and formalin-induced paw edema models....
Source: Inflammopharmacology - February 17, 2024 Category: Drugs & Pharmacology Source Type: research
Association of statin use with osteoporosis risk: a drug-targeted Mendelian randomization study
ConclusionThese evidence supported a protective effect of HMGCR-mediated non-HDL cholesterol reduction or statin use against osteoporosis. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 16, 2024 Category: Drugs & Pharmacology Source Type: research
Flavipin from fungi as a potential inhibitor of rheumatoid arthritis signaling molecules
AbstractFlavipin, a fungal lower molecular weight biomolecule (MW 196.16 g/mol), has not been yet extensively studied for beneficial preclinical and clinical applications. In recent years, various preclinical mouse models including adjuvant-induced arthritis (AIA) were employed to understand mechanisms associated with Rheumatoid arthritis (RA) and to develop new therapeutic drugs. In the current study, we studied the inhibitory effect of Flavipin on major signaling molecules involved in the inflammatory response during RA using both in-silico virtual interaction and in vivo mouse model of AIA. Ourin-silico results clarifie...
Source: Inflammopharmacology - February 13, 2024 Category: Drugs & Pharmacology Source Type: research
Role of corticosteroids in the treatment of critically ill sepsis patients: a meta-analysis review
ConclusionIn summary, corticosteroids can reduce the death rate of critically ill sepsis patients to a certain extent and have good clinical application value. (Source: Inflammopharmacology)
Source: Inflammopharmacology - February 12, 2024 Category: Drugs & Pharmacology Source Type: research
