Resolvin D1 attenuates depressive-like behavior in LPS-challenged mice by promoting microglial autophagy
In conclusion, our findings shed new light on the involvement of microglial autophagy in SAE and emphasize the potential benefits of RvD1 as a promising therapeutic agent in the treatment of depression. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 27, 2023 Category: Drugs & Pharmacology Source Type: research
Empagliflozin attenuates intestinal inflammation through suppression of nitric oxide synthesis and myeloperoxidase activity in in vitro and in vivo models of colitis
AbstractInflammatory bowel diseases (IBD) are characterized by chronic and relapsing inflammation affecting the gastrointestinal (GI) tract. The incidence and prevalence of IBD are relatively high and still increasing. Additionally, current therapeutic strategies for IBD are not optimal. These facts urge todays ’ medicine to find a novel way to treat IBD. Here, we focused on the group of anti-diabetic drugs called gliflozins, which inhibit sodium glucose co-transporter type 2 (SGLT-2). Numerous studies demonstrated that gliflozins exhibit pleiotropic effect, including anti-inflammatory properties. In thi s study, we test...
Source: Inflammopharmacology - April 22, 2023 Category: Drugs & Pharmacology Source Type: research
Chrysin, a 5,7-dihydroxyflavone restrains inflammatory arthritis in rats via subsiding oxidative stress biomarkers and inflammatory cytokines
This study was intended to appraise the anti-inflammatory and anti-arthritic potential of Chrysin (CR), a natural dietary flavone found in several plant genera, includingPassiflora andPropalis, and honey. The in vitro anti-arthritic potential was assessed by protein denaturation and membrane stabilization assays. The acute anti-inflammatory action was assessed by Carrageenan and Xylene induced oedema models in Wistar rats. For determining anti-arthritic potential, 0.1 ml Complete Freund’s adjuvant was injected into the left hind paw of rats to induce adjuvant-induced arthritis, followed by initiation of treatment with ...
Source: Inflammopharmacology - April 21, 2023 Category: Drugs & Pharmacology Source Type: research
Diabetes as one of the long-term COVID-19 complications: from the potential reason of more diabetic patients ’ susceptibility to COVID-19 to the possible caution of future global diabetes tsunami
AbstractAccording to recent researches, people with diabetes mellitus (type 1 and 2) have a higher incidence of coronavirus disease 2019 (COVID-19), which is caused by a SARS-CoV-2 infection. In this regard, COVID-19 may make diabetic patients more sensitive to hyperglycemia by modifying the immunological and inflammatory responses and increasing reactive oxygen species (ROS) predisposing the patients to severe COVID-19 and potentially lethal results. Actually, in addition to COVID-19, diabetic patients have been demonstrated to have abnormally high levels of inflammatory cytokines, increased virus entrance, and decreased ...
Source: Inflammopharmacology - April 20, 2023 Category: Drugs & Pharmacology Source Type: research
Diosmetin alleviates acute lung injury caused by lipopolysaccharide by targeting barrier function
AbstractAcute lung injury (ALI) is an acute and devastating disease caused by systemic inflammation e.g. patients infected with bacteria and viruses such as SARS-CoV-2 have an unacceptably high mortality rate. It has been well documented that endothelial cell damage and repair play a central role in the pathogenesis of ALI because of its barrier function. Nevertheless, the leading compounds that effectively accelerate endothelial cell repair and improve barrier dysfunction in ALI are largely unknown. In the present study, we found that diosmetin had promising characteristics to inhibit the inflammatory response and acceler...
Source: Inflammopharmacology - April 19, 2023 Category: Drugs & Pharmacology Source Type: research
The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Conclusion Overall, evidence from RCTs suggests a survival benefit for vitamin C in patients with severe COVID-19. However, we should await data from large-scale randomized trials to affirm its mortality benefits. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 18, 2023 Category: Drugs & Pharmacology Source Type: research
Pterostilbene reduces the progression of atopic dermatitis via modulating inflammatory and oxidative stress biomarkers in mice
This study was intended to evaluate the effect of PTN against atopic dermatitis. The disease was induced by sensitization with 2,4-dinitrochlorobenzene (DNCB) in mice. The standard control group (SCG) received topical 0.1% tacrolimus (TC), whereas three other treatment groups received daily topical PTN at 0.2, 0.6, and 1% w/w for 28 days. Dermatitis scoring, ear thickness, and body weight of animals were weekly determined while other parameters were assessed at the termination of the experiment. PTN reduced the ear weight, skin thickness, and the weight and size of thymus glands and spleen in comparison with diseased ani...
Source: Inflammopharmacology - April 17, 2023 Category: Drugs & Pharmacology Source Type: research
Microglia polarization in nociplastic pain: mechanisms and perspectives
AbstractNociplastic pain is the third classification of pain as described by the International Association for the Study of Pain (IASP), in addition to the neuropathic and nociceptive pain classes. The main pathophysiological mechanism for developing nociplastic pain is central sensitization (CS) in which pain amplification and hypersensitivity occur. Fibromyalgia is the prototypical nociplastic pain disorder, characterized by allodynia and hyperalgesia. Much scientific data suggest that classical activation of microglia in the spinal cord mediates neuroinflammation which plays an essential role in developing CS. In this r...
Source: Inflammopharmacology - April 17, 2023 Category: Drugs & Pharmacology Source Type: research
Nanomedicines: intervention in inflammatory pathways of cancer
AbstractInflammation is a complex defense process that maintains tissue homeostasis. However, this complex cascade, if lasts long, may contribute to pathogenesis of several diseases. Chronic inflammation has been exhaustively studied in the last few decades, for its contribution in development and progression of cancer. The intrinsic limitations of conventional anti-inflammatory and anti-cancer therapies triggered the development of nanomedicines for more effective and safer therapies. Targeting inflammation and tumor cells by nanoparticles, encapsulated with active therapeutic agents, offers a promising outcome with patie...
Source: Inflammopharmacology - April 15, 2023 Category: Drugs & Pharmacology Source Type: research
New insights on mode of action of vasorelaxant activity of simvastatin
AbstractSimvastatin is a semisynthetic inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is used extensively to treat atherosclerotic cardiovascular disease. Apart from the lipid-lowering effect, simvastatin has been documented to offer impressive vasorelaxant activity. However, the mechanism associated with this vasorelaxant activity has yet not been substantially explored. Thus, the present study has aimed to elucidate the mechanism(s) associated with simvastatin-induced vasorelaxation using an established rat aortic ring model. The results from the study depicted that simvastatin caused signific...
Source: Inflammopharmacology - April 10, 2023 Category: Drugs & Pharmacology Source Type: research
The effect of Nigella sativa (black seed) on biomarkers of inflammation and oxidative stress: an updated systematic review and meta-analysis of randomized controlled trials
ConclusionN. sativa supplementation had beneficial effects on CRP, TNF- α, MDA, SOD, GPx, and TAC. Thus,Nigella sativa can be recommended as an adjuvant anti-oxidant agent and anti-inflammatory. (Source: Inflammopharmacology)
Source: Inflammopharmacology - April 10, 2023 Category: Drugs & Pharmacology Source Type: research
Anakinra for the prophylaxis of venous thromboembolism in patients with COVID-19
(Source: Inflammopharmacology)
Source: Inflammopharmacology - April 10, 2023 Category: Drugs & Pharmacology Source Type: research
In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats
AbstractInflammation is a complex and crucial process that protects the body against pathogens. Here in our study, we propose to scientifically justify the anti-inflammatory activity of olive leaf (OL). Initially, we ensured the safety of olive leaf extract (OLE) through acute oral administration of graded doses up to 4 g\kg in Wistar rats. Thus, the extract was considered generally safe. We also evaluated the ability of the extract to reduce carrageenan-induced rat paw edema. Compared to diclofenac sodium (10 mg/kg PO), OLE showed significant (P < 0.05) anti-inflammatory activity, showing the maximum inhibition...
Source: Inflammopharmacology - April 8, 2023 Category: Drugs & Pharmacology Source Type: research
Crosstalk between phytochemicals and inflammatory signaling pathways
AbstractNovel bioactive constituents from natural sources are actively being investigated. The phytochemicals in these phenolic compounds are believed to have a variety of beneficial effects on human health. Several phenolic compounds have been found in plants. The antioxidant potential of phenols has been discussed in numerous studies along with their anti-inflammatory effects on pro-inflammatory cytokine, inducible cyclooxygenase-2, and nitric oxide synthase. Through current study, an attempt is made to outline and highlight a wide variety of inflammation-associated signaling pathways that have been modified by several n...
Source: Inflammopharmacology - April 6, 2023 Category: Drugs & Pharmacology Source Type: research
Biseugenol from Ocotea cymbarum (Lauraceae) attenuates inflammation, angiogenesis and collagen deposition of sponge-induced fibrovascular tissue in mice
AbstractSeveral species of the genusOcotea are used in traditional medicine due to their anti-inflammatory and analgesic properties. In this work we sought to investigate the effects of biseugenol, the main component of the hexane extract from the leaves ofOcotea cymbarum (Lauraceae), during a chronic inflammatory process induced by polyester-polyurethane sponge in mice. In addition to the inflammatory component, sponge discs also allowed us to evaluate parameters associated with the formation of new blood vessels and the deposition and organization of the extracellular matrix, processes that are related to the chronificat...
Source: Inflammopharmacology - April 6, 2023 Category: Drugs & Pharmacology Source Type: research
