Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway
AbstractMedulla Tetrapanacis (MT) is a commonly used herb to promote lactation and manage mastitis in lactating mothers. However, its anti-inflammatory and anti-bacterial effects are currently unknown. We hypothesized that MT water extract possesses anti-inflammatory and anti-bacterial effects by modulating macrophage polarization to reduce the release of inflammatory mediators and phagocytosis via inactivation of MAPKs pathways. The chemical composition of the MT water extract was analyzed by UPLC-Orbitrap-mass spectrometry. The anti-inflammatory and anti-bacterial properties of the MT water extract were examined using LP...
Source: Inflammopharmacology - July 10, 2023 Category: Drugs & Pharmacology Source Type: research
Galantamine mitigates testicular injury and disturbed spermatogenesis in adjuvant arthritic rats via modulating apoptosis, inflammatory signals, and IL-6/JAK/STAT3/SOCS3 signaling
In conclusion, GAL has potential protective effects on testicular damage secondary to RA via counteracting testicular inflammat ion, apoptosis, and inhibiting IL-6/JAK/STAT3/SOCS3 signaling.Graphical abstract (Source: Inflammopharmacology)
Source: Inflammopharmacology - July 10, 2023 Category: Drugs & Pharmacology Source Type: research
Pyroptosis: the potential eye of the storm in adult-onset Still ’s disease
AbstractPyroptosis, a form of programmed cell death with a high pro-inflammatory effect, causes cell lysis and leads to the secretion of countless interleukin-1 β (IL-1β) and IL-18 cytokines, resulting in a subsequent extreme inflammatory response through the caspase-1-dependent pathway or caspase-1-independent pathway. Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease with extensive disease manifestations and severe complications su ch as macrophage activation syndrome, which is characterized by high-grade inflammation and cytokine storms regulated by IL-1β and IL-18. To date, the pathogenesis of ...
Source: Inflammopharmacology - July 10, 2023 Category: Drugs & Pharmacology Source Type: research
Clinical efficacy and safety of melatonin supplementation in multiple sclerosis: a systematic review
This study was executed following the PRISMA 2020 statement. Both observational and interventional studies which reported the clinical effectiveness and/or safety of melatonin supplementation in patients with MS were included in this systematic review. Ovid, PubMed, Scopus, Embase, and Web of Science databases were searched and the risk of bias in included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools based on study design.ResultsOut of 1304 results of database searches, finally, 14 articles, including 7 randomized controlled trials (RCTs), 6 case –control studies, and one quasi-ex...
Source: Inflammopharmacology - July 10, 2023 Category: Drugs & Pharmacology Source Type: research
Pharmaceutical aspects of novel CGRP inhibitors used in the prophylaxis and treatment of migraine
AbstractMigraine is one of the most prevalent neurological disorders known to have an immense adverse socio-economic impact. Neurogenic inflammation is thought to mediate migraine, and CGRP is known to be released during acute attacks of migraine that causes vasodilation in extracerebral arteries. Hence, CGRP is believed to play a key role in triggering migraine. Although there are several classes of medications used in the prevention and treatment of migraine pain, targeted therapies are fewer. Therefore, CGRP receptor inhibitors which bind to CGRP receptors in the cranial vasculature have been developed as drugs for migr...
Source: Inflammopharmacology - July 8, 2023 Category: Drugs & Pharmacology Source Type: research
In vitro anti-inflammatory activity and ameliorative effects on gastric ulcers of Licania rigida benth seed extract
AbstractLicania rigida Benth., a Brazilian endemic plant, has been traditionally used for treating inflammation and stomach pain. This work investigates the anti-inflammatory and gastroprotective activities of the ethanolic extract fromL. rigida seeds (EELr) by in vitro and in vivo methods. The phytochemical profile was determined and the in vitro antioxidant activity was investigated by radical scavenging and thiobarbituric acid reactive substances methods. The ovalbumin denaturation method was used with sodium diclofenac as standard for the in vitro anti-inflammatory activity assessment. Acetylsalicylic acid was used to ...
Source: Inflammopharmacology - July 7, 2023 Category: Drugs & Pharmacology Source Type: research
The association between neutrophil-to-lymphocyte ratio and disease activity in rheumatoid arthritis
AbstractThe inflammatory response is responsible for the promotion of pannus development over the joint, which is the primary factor in joint injury in rheumatoid arthritis (RA). More in-depth investigations have been conducted in recent years leading to a greater understanding of RA. Yet, it's difficult to gauge inflammation levels in RA patients. Some people who have RA do not exhibit normal symptoms, which makes it more challenging to make a diagnosis. Typical RA evaluations are subject to a few restrictions. Earlier research demonstrated that some patients continued to experience the progression of bone and joint degen...
Source: Inflammopharmacology - July 7, 2023 Category: Drugs & Pharmacology Source Type: research
Beneficial role of kaempferol and its derivatives from different plant sources on respiratory diseases in experimental models
AbstractRespiratory illnesses impose a significant health burden and cause deaths worldwide. Despite many advanced strategies to improve patient outcomes, they are often less effective. There is still considerable room for improvement in the treatment of various respiratory diseases. In recent years, alternative medicinal agents derived from food plants have shown better beneficial effects against a wide variety of disease models, including cancer. In this regard, kaempferol (KMF) and its derivatives are the most commonly found dietary flavonols. They have been found to exhibit protective effects on multiple chronic diseas...
Source: Inflammopharmacology - July 6, 2023 Category: Drugs & Pharmacology Source Type: research
Zinc and L-carnitine combination with or without methotrexate prevents intestinal toxicity during arthritis treatment via Nrf2/Sirt1/Foxo3 pathways: an In vivo and molecular docking approach
In conclusion, we report that Zn Lc and MTX combination could presumably protect the intestine from low-dose MTX which managed arthritis but induced severe intestina l damage with increased inflammation and downregulated Nrf2/Sirt1/Foxo3 pathway. (Source: Inflammopharmacology)
Source: Inflammopharmacology - July 5, 2023 Category: Drugs & Pharmacology Source Type: research
The orchestrating role of deteriorating neurons and TREM-1 in crosstalk with SYK in Alzheimer ’s disease progression and neuroinflammation
AbstractAlzheimer ’s disease (AD) is a progressive type of neurodegenerative disease characterized by successive loss of the conventional structure and functions of neurons. In addition to dead neurons type detected within AD brain tissues, there are a predominantly varying number of deteriorating neurons (DTNs). A s the number of deteriorating neurons increases, they exaggerate the release of inflammatory factors and oxidative stress that trigger the cascade of neuroinflammation. Triggering receptor expressed on myeloid cells 1 (TREM-1) which is a transmembrane immune receptor type regularly expressed by phag ocytic cel...
Source: Inflammopharmacology - July 5, 2023 Category: Drugs & Pharmacology Source Type: research
Silver nanoparticles synthesized from Quercus brantii ameliorated ethanol-induced gastric ulcers in rats by decreasing oxidative stress and improving antioxidant systems
This study was conducted to investigate the protective and antioxidant effects of silver nanoparticles synthesized fromQuercus brantii extract (NSQBE) on gastric damage induced by alcohol in rats. In this study, silver nanoparticles were produced by the green synthesis method using oak extract. The structure and morphology of nanoparticles were confirmed by various techniques such as UV –Vis spectroscopy, fourier transforms infrared spectrometer (FTIR), scanning electron microscope (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy-dispersive X-ray analysis (EDX), and dynamic light scatterin...
Source: Inflammopharmacology - July 5, 2023 Category: Drugs & Pharmacology Source Type: research
Vaccination with Toxoplasma lysate antigen or its encapsulated niosomes form immunomodulates adjuvant-induced arthritis through JAK3 downregulation
ConclusionVaccination with both TLA and TLA-encapsulated niosomes for the first time in adjuvant-induced arthritis ameliorated the disease through diversion of immune system and JAK3 downregulation. Both vaccinations should be further tested to evaluate the possibility of their introduction for disease treatment and in other autoimmune diseases. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 30, 2023 Category: Drugs & Pharmacology Source Type: research
Long COVID and possible preventive options
AbstractMost of the people who suffered from COVID-19 fully recovered, but approximately 10 –20% of them developed a wide variety of symptoms after they recover from their initial illness. Long COVID can develop at any patient; however, several studies suggest that the development of Long Covid syndrome may be linked to severity of acute illness. Some of the risk factors are hospitalizat ion (with mechanical ventilation), Intensive Care Unit admission, age (over 50 years), gender (female) and comorbidities. Since the precise mechanism of Long COVID has not been clarified, neither the management of Long COVID-19 syndrome...
Source: Inflammopharmacology - June 21, 2023 Category: Drugs & Pharmacology Source Type: research
Mito-TEMPO mitigates 5-fluorouracil-induced intestinal injury via attenuating mitochondrial oxidative stress, inflammation, and apoptosis: an in vivo study
ConclusionMito-TEMPO exerted significant protective effect against 5-FU-induced intestinal toxicity. Therefore, it may be used as an adjuvant in 5-FU chemotherapy. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 20, 2023 Category: Drugs & Pharmacology Source Type: research
The potential effect of metformin on fibroblast growth factor 21 in type 2 diabetes mellitus (T2DM)
In conclusion, metformin advances FGF21 signaling and decreases FGF21 resistance in T2DM, and this might be an innovative mechanism for metformin in the enhancement of glucose homeosta sis and metabolic disorders in T2DM patients. (Source: Inflammopharmacology)
Source: Inflammopharmacology - June 19, 2023 Category: Drugs & Pharmacology Source Type: research
