Pollen and bee bread expressed highest anti-inflammatory activities among bee products in chronic inflammation: an experimental study with cotton pellet granuloma in rats
AbstractLittle is known about the effectiveness of bee products on chronic inflammation. In this experimental study, it was aimed to investigate and compare the anti-inflammatory activities of honey, propolis, royal jelly, pollen and bee bread, for the first time in the literature. In the study, 48 Sprague Dawley female albino rats weighing 200 ± 20 g were used and bee products were administered by oral gavage method. Healthy, control, honey, propolis, pollen, royal jelly and bee bread groups were randomized. Chronic inflammation was created by cotton pellet method. For the treatments, 1 g/kg of honey, 300 mg/kg/d...
Source: Inflammopharmacology - March 15, 2023 Category: Drugs & Pharmacology Source Type: research
Long-COVID syndrome: physical –mental interplay in the spotlight
AbstractPatients suffering from Long-COVID syndrome experience a variety of different symptoms on a physical, but also on a psychological and social level. Previous psychiatric conditions such as depression and anxiety have been identified as separate risk factors for developing Long-COVID syndrome. This suggests a complex interplay of different physical and mental factors rather than a simple cause –effect relationship of a specific biological pathogenic process. The biopsychosocial model provides a foundation for understanding these interactions and integrating them into a broader perspective of the patient suffering f...
Source: Inflammopharmacology - March 9, 2023 Category: Drugs & Pharmacology Source Type: research
COVID-19-induced neurological symptoms: focus on the role of metal ions
AbstractNeurological symptoms are prevalent in both the acute and post-acute phases of coronavirus disease 2019 (COVID-19), and they are becoming a major concern for the prognosis of COVID-19 patients. Accumulation evidence has suggested that metal ion disorders occur in the central nervous system (CNS) of COVID-19 patients. Metal ions participate in the development, metabolism, redox and neurotransmitter transmission in the CNS and are tightly regulated by metal ion channels. COVID-19 infection causes neurological metal disorders and metal ion channels abnormal switching, subsequently resulting in neuroinflammation, oxida...
Source: Inflammopharmacology - March 9, 2023 Category: Drugs & Pharmacology Source Type: research
Neuroprotective effect of tangeretin against chromium-induced acute brain injury in rats: targeting Nrf2 signaling pathway, inflammatory mediators, and apoptosis
In conclusion, TNG possesses a significant neuroprotective role against PD-induced acute brain injury via modulating the Nrf2 signaling pathway and quenching the release of inflammatory mediators and apoptosis in rats.Graphical abstract (Source: Inflammopharmacology)
Source: Inflammopharmacology - March 8, 2023 Category: Drugs & Pharmacology Source Type: research
Potential effects of carbon monoxide donor and its nanoparticles on experimentally induced gastric ulcer in rats
In conclusion, the CO released by CORM2 can protect against INDO-induced gastric ulcers dose dependently, and the highest used dose had no effect on COHb concentration. (Source: Inflammopharmacology)
Source: Inflammopharmacology - March 8, 2023 Category: Drugs & Pharmacology Source Type: research
