Meta-analysis of the anti-oxidative and anti-inflammatory effects of hypoglycaemic plant-derived medicines
ConclusionsSeveral hypoglycaemic plant-based treatments appear to positively affect T2DM patients by concurrently lowering oxidative stress and inflammatory indicators and boosting antioxidant enzyme activity.Clinical Trail RegistryPROSPERO ID: CRD42021226147. (Source: Inflammopharmacology)
Source: Inflammopharmacology - September 2, 2023 Category: Drugs & Pharmacology Source Type: research
The effects of L-carnitine supplementation on inflammatory and anti-inflammatory markers in adults: a systematic review and dose –response meta-analysis
AbstractL-carnitine supplementation may be beneficial in improving inflammatory conditions and reducing the level of inflammatory cytokines. Therefore, according to the finding of randomized controlled trials (RCTs), the systematic review and meta-analysis aimed to investigate the effect of L-carnitine supplementation on inflammation in adults. To obtain acceptable articles up to October 2022, a thorough search was conducted in databases including PubMed, ISI Web of Science, the Cochrane Library, and Scopus. A random-effects model was used to estimate the weighted mean difference (WMD). We included the 48 RCTs (n = 325...
Source: Inflammopharmacology - September 1, 2023 Category: Drugs & Pharmacology Source Type: research
Preemptive QP001, a fast-acting meloxicam formulation, provides analgesia and reduces opioid consumption following abdominal surgery: a randomized controlled trial
ConclusionPreoperative/preemptive QP001 provides analgesia and reduces opioid consumption in patients with moderate to severe pain following abdominal surgery, while maintaining a favorable safety profile. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 30, 2023 Category: Drugs & Pharmacology Source Type: research
Treatment of ankylosing spondylitis with TNF α inhibitors does not affect serum levels of tryptophan metabolites
AbstractThe imbalance between the kynurenine and serotonin pathways can have serious consequences, e.g., depression. One of the factors leading to the imbalance between the pathways of tryptophan metabolism is inflammation. The aim of our study was to assess the impact of treatment with tumor necrosis factor-alpha (TNF α)-inhibitors on tryptophan metabolism in patients with ankylosing spondylitis (AS). Forty patients with AS (twenty-eight males, twelve females; mean age 40 ± 11 years), qualified to receive anti-TNF-α treatment, were prospectively assessed. As a control group, 20 healthy volunteers (7 males and 13 f...
Source: Inflammopharmacology - August 30, 2023 Category: Drugs & Pharmacology Source Type: research
Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties
AbstractThe aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertreeSchinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–...
Source: Inflammopharmacology - August 28, 2023 Category: Drugs & Pharmacology Source Type: research
Treatment of rheumatic musculoskeletal disorders
AbstractNon-medicinal therapies with water, salts, exercise, massage, supportive devices, and electricity have been used for centuries and continue to be of benefit for some people with musculoskeletal disorders. Historical texts refer to the two electuaries mithridatium and theriaca as early therapeutic attempts of man to provide relief of musculoskeletal symptoms and attempt disease cures. For over 200 years, morphine-derived products have been used for musculoskeletal pain. The development of acetyl salicylic acid was a major breakthrough in joint pain management. This was followed by the introduction of nonsteroidal ...
Source: Inflammopharmacology - August 26, 2023 Category: Drugs & Pharmacology Source Type: research
Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation
AbstractUp to 50% of systemic lupus erythematosus (SLE) patients world-wide develop lupus nephritis (LN). In low to middle income countries and in particular in sub-Saharan Africa, where SLE is prevalent with a more aggressive course, LN and end stage renal disease is a major cause of mortality. While developed countries have the funding to invest in SLE and LN research, patients of African descent are often underrepresented in clinical trials. Thus, the complex influence of ethnicity and genetic background on outcome of LN and SLE as a whole, is not fully understood. Several pathophysiological mechanisms including major r...
Source: Inflammopharmacology - August 25, 2023 Category: Drugs & Pharmacology Source Type: research
High-dose ascorbic acid potentiates immune modulation through STAT1 phosphorylation inhibition and negative regulation of PD-L1 in experimental sepsis
This study aimed to investigate the protective effects of high-dose ascorbic acid on experimental sepsis. Results show that intravenous administration of high-dose ascorbic acid (250 mg/kg) attenuated sepsis-induced organ dysfunctions in a cecal ligation and puncture (CLP)-induced septic mouse model. Ascorbic acid improved splenic cell apoptosis and increased the number of CD3+ T cells in septic mice induced by CLP. Furthermore, ascorbic acid downregulated PD-L1 expression in livers, reduced PD-1 expression in spleens, and inhibited the phosphorylation of STAT1 at Y701 in multiple organs of CLP-induced septic mice. The i...
Source: Inflammopharmacology - August 24, 2023 Category: Drugs & Pharmacology Source Type: research
Folic acid improved memory and learning function in a rat model of neuroinflammation induced by lipopolysaccharide
In conclusion, FA could ameliorate the memory and learning deficits induced by LPS via normalizing the inflammatory response and oxidative stress markers in the brain. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 23, 2023 Category: Drugs & Pharmacology Source Type: research
Anti-inflammatory, cardioprotective effect of gypenoside against isoproterenol-induced cardiac remodeling in rats via alteration of inflammation and gut microbiota
ConclusionGypenoside acts as a protective phytoconstituents against the ISO-induced myocardial infraction in the rats via alteration of gut microbiota, inflammatory, and oxidative stress. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 21, 2023 Category: Drugs & Pharmacology Source Type: research
Ibuprofen, other NSAIDs and COVID-19: a narrative review
AbstractAt the start of the coronavirus disease 2019 (COVID-19) pandemic (March 2020), there was speculation that non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, used to manage some of the symptoms of COVID-19, could increase the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and negatively impact clinical outcomes. In the absence of any robust mechanistic and clinical evidence, this speculation led to confusion about the safety of ibuprofen, contributing to the so-called ‘infodemic’ surrounding COVID-19. A wealth of evidence has been generated in subsequent y...
Source: Inflammopharmacology - August 21, 2023 Category: Drugs & Pharmacology Source Type: research
Comparison of gastrointestinal adverse events between fast release tablets and regular acetylsalicylic acid (aspirin) galenics after short-term use: a meta-analysis of randomized clinical trials
In conclusion, aspirin FR tablets showed a comparable GI tolerability to regular galenic formulations of aspirin after short-term treatment. M ajor GI complication did not occur after intake of any galenic formulation of aspirin. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 21, 2023 Category: Drugs & Pharmacology Source Type: research
The citrus flavonoid “Nobiletin” impedes STZ-induced Alzheimer’s disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism
AbstractThe prominence of autophagy in the modulation of neurodegenerative disorders has sparked interest to investigate its stimulation in Alzheimer's disease (AD). Nobiletin possesses several bioactivities such as anti-inflammation, antioxidation, and neuroprotection. Consequently, the study's aim was to inspect the possible neurotherapeutic impact of Nobiletin in damping AD through autophagy regulation. Mice were randomly assigned into: Group I which received DMSO, Groups II, III, and IV obtained STZ (3 mg/kg) intracerebroventricularly once with Nobiletin (50 mg/kg/day; i.p.) in Group III and Nobiletin with EX-527 (2...
Source: Inflammopharmacology - August 19, 2023 Category: Drugs & Pharmacology Source Type: research
Erythropoietin alleviates astrocyte pyroptosis by targeting the miR-325-3p/Gsdmd axis in rat spinal cord injury
ConclusionsWe demonstrated that erythropoietin can inhibit astrocyte pyroptosis through the miR-325-3p/Gsdmd axis. This study is expected to provide a new mechanism for erythropoietin in the treatment of SCI and a more reliable theoretical basis for clinical research. (Source: Inflammopharmacology)
Source: Inflammopharmacology - August 14, 2023 Category: Drugs & Pharmacology Source Type: research
Sesquiterpene from Artemisia argyi seed extracts: A new anti-acute peritonitis agent that suppresses the MAPK pathway and promotes autophagy
AbstractTo find novel anti-inflammatory drugs, we screened anti-inflammatory compounds from 18 different types ofArtemisia argyi seed extracts. The in vitro and in vivo anti-inflammatory activities of the screened compounds and their mechanisms were characterized. We first detected the cytotoxic effect of the compounds on RAW264.7 cells and the inhibitory effect on LPS-induced NO release. It was found that sesquiterpenoids CA-2 and CA-4 had low cytotoxic and strong NO inhibitory activity with an IC50 of 4.22 ± 0.61 μM and 2.98 ± 0.23 μM for NO inhibition, respectively. Therefore, compound CA-4 was studied in...
Source: Inflammopharmacology - August 14, 2023 Category: Drugs & Pharmacology Source Type: research
