The effects of probiotic supplements on oxidative stress and inflammation in subjects with mild and moderate Alzheimer ’s disease: a randomized, double-blind, placebo-controlled study

AbstractThrough modulating effects on the gut-brain axis, probiotics are an effective adjuvant treatment for Alzheimer ’s disease (AD), one of our century’s most important medical care challenges (Agahi et al. Front Neurol 9:662, 2018). This trial aimed to examine the effects of two different single-strain probiotics on oxidative stress and inflammation in patients with mild and moderate AD. This was a 12-week p lacebo-controlled, double-blind, randomized clinical trial performed on 90 patients with AD. Eligible patients were randomly assigned to two different interventions (Lacticaseibacillus rhamnosus HA-114 (7.5  × 109) orBifidobacterium longum R0175 (7.5  × 109)) and a placebo group, supplemented twice daily. We used mixed-effect models to examine the probiotic ’s independent effects on clinical results. Significant improvements in serum inflammatory and oxidative stress markers were observed at the end of the trial (P <  0.05). Probiotic supplementation for 12 weeks had beneficial effects on oxidative stress, inflammation, quality of life, and physical activity in patients with mild and moderate AD.
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research