A rapid screening color test for glyphosate using dabsyl derivatization
ConclusionsA simple screening method for glyphosate based on a color test was established. The method is rapid and requires less than 30 μL of samples. The sensitivity was sufficient for most cases of moderate to severe poisoning. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 19, 2018 Category: Forensic Medicine Source Type: research
Profile of new psychoactive substances (NPS) and other synthetic drugs in seized materials analysed in a Brazilian forensic laboratory
(Source: Forensic Toxicology)
Source: Forensic Toxicology - November 28, 2018 Category: Forensic Medicine Source Type: research
The search for the “next” euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning
ConclusionsInternational early warning systems are an essential part of tracking emerging psychoactive substances and allow responsive action to be taken to facilitate the gathering of relevant data for detailed risk assessments. Pre-emptive research on the most likely compounds to emerge next, so providing drug metabolism and pharmacokinetic data to ensure that new substances are detected early in toxicological samples is recommended. As these compounds are chiral compounds and stereochemistry has a large effect on their potency, it is recommended that detection methods consider the determination of configuration. (Source...
Source: Forensic Toxicology - November 28, 2018 Category: Forensic Medicine Source Type: research
Use of polysaccharide-based chiral columns: enantiomeric separation of seven pairs of abused drugs by high-performance liquid chromatography –mass spectrometry
(Source: Forensic Toxicology)
Source: Forensic Toxicology - November 24, 2018 Category: Forensic Medicine Source Type: research
∆ 9 -Tetrahydrocannabinol, a major marijuana component, enhances the anesthetic effect of pentobarbital through the CB 1 receptor
ConclusionsThese results suggest that binding of ∆9-THC to the CB1 receptor is involved in the synergism with pentobarbital, and that potentiating effect of CBD with pentobarbital may differ from that of ∆9-THC. We successfully demonstrated that ∆9-THC enhanced the anesthetic effect of pentobarbital through the CB1 receptor. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 24, 2018 Category: Forensic Medicine Source Type: research
Quantification of seven novel synthetic opioids in blood using LC –MS/MS
ConclusionsA quantification method for seven synthetic opioids (U-47700, AH-7921, U-49900, U-50488, MT-45, W-18, and W-15) in whole blood was developed, optimized, and validated in accordance with SWGTOX standard practices for method validation in forensic toxicology. This sensitive method was successfully applied to postmortem casework. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 22, 2018 Category: Forensic Medicine Source Type: research
Forensic analysis using ultra-high-performance liquid chromatography –tandem mass spectrometry with solid-phase extraction of α-solanine and α-chaconine in whole blood
ConclusionsThis validated UHPLC –MS/MS with SPE for quantitative analysis of PGAs could be useful in forensic toxicology. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 19, 2018 Category: Forensic Medicine Source Type: research
Unstability of 4-CMC in human serum specimen
(Source: Forensic Toxicology)
Source: Forensic Toxicology - November 19, 2018 Category: Forensic Medicine Source Type: research
5F-Cumyl-PINACA in ‘e-liquids’ for electronic cigarettes: comprehensive characterization of a new type of synthetic cannabinoid in a trendy product including investigations on the in vitro and in vivo phase I metabolism of 5F-Cumyl-PINACA and its non-fluorinated analog Cumyl-PINACA
ConclusionsThe increasing popularity of e-liquids particularly among young people, and the extreme potency of the added SCs, pose a serious threat to public health. To our knowledge, this is the first report describing the tentative identification of human in vivo metabolites of Cumyl-PINACA and 5F-Cumyl-PINACA. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 13, 2018 Category: Forensic Medicine Source Type: research
Metabolism of triacetone triperoxide (TATP) by canine cytochrome P450 2B11
ConclusionsTATP does not react as MEKP suggesting that TATP does not ring-open to form hydroperoxides. TATP and TATP-OH compete for the same enzyme, with TATP dominating this competition. Failure to detect additional metabolite(s) suggests they may be too small to detect by our system or bound covalently to a protein or polymer in the incubation reaction. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 9, 2018 Category: Forensic Medicine Source Type: research
A GC –MS method for the determination of furanylfentanyl and ocfentanil in whole blood with full validation
ConclusionsThe developed method is the first one in the literature for the detection of furanylfentanyl and ocfentanil in biological fluids by GC –MS, and it provides very high sensitivity comparable to that by liquid chromatography–tandem mass spectrometry. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 22, 2018 Category: Forensic Medicine Source Type: research
Sensitive quantification of BB-22 and its metabolite BB-22 3-carboxyindole, and characterization of new metabolites in authentic urine and/or serum specimens obtained from three individuals by LC –QTRAP-MS/MS and high-resolution LC–Orbitrap-MS/MS
ConclusionsThe synthetic cannabinoid BB-22 and its metabolite BB-22 3-carboxyindole were identified and quantified in authentic human serum and urine specimens for the first time, and new metabolites of BB-22 were tentatively identified in authentic urine specimens obtained from three drug users in this study. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 16, 2018 Category: Forensic Medicine Source Type: research
Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE
Conclusions5F-CUMYL-PEGACLONE was subject to extensive metabolism in humans. The propionic acid metabolite was the most abundant metabolite in all urine samples and should be targeted when maximum sensitivity is needed (e.g., drug abstinence control). However, this metabolite also occurs in the biotransformation of the non-fluorinated analog and is, therefore, not a compound-specific marker. For differentiation, a metabolite hydroxylated at theγ-carbolinone core showed to be the most reliable marker and should be used as an additional target analyte. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 5, 2018 Category: Forensic Medicine Source Type: research
Immunoassay-based detection of fentanyl analogs in forensic toxicology
In this study, the cross-reactivity of 13 fentalogs were investigated using five commercially available kits.MethodsDose –response curves were generated using sixN-acyl-substituted fentalogs (4-ANPP, acetylfentanyl, butyrylfentanyl, furanylfentanyl, isobutyrylfentanyl, valerylfentanyl), one desphenethyl fentalog (norfentanyl), two piperidine-modified [(+)-cis-3-methylfentanyl, carfentanil], and four phenethyl and piperidine substituted fentalogs (alfentanil, norcarfentanil, remifentanil, sufentanil). Cross-reactivities were estimated for each assay to determine its overall effectiveness for fentalog screening in toxicolo...
Source: Forensic Toxicology - October 3, 2018 Category: Forensic Medicine Source Type: research
