Identification and characterization of the new psychoactive substance 3-fluoroethamphetamine in seized material
ConclusionsCharacterization data were compiled in order to provide the scientific community with sufficient information to allow a quick and accurate determination of 3-fluoroethamphetamine in future seizures. (Source: Forensic Toxicology)
Source: Forensic Toxicology - May 3, 2018 Category: Forensic Medicine Source Type: research
Fatal case of poisoning with a new cathinone derivative: α-propylaminopentiophenone (N-PP)
ConclusionsTo the best of the authors' knowledge, this is the first case reported in the literature on fatal poisoning with α-propyloaminopentiophenone. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 27, 2018 Category: Forensic Medicine Source Type: research
Pharmacological evaluation of new constituents of “Spice”: synthetic cannabinoids based on indole, indazole, benzimidazole and carbazole scaffolds
ConclusionsThese results will be useful to assess the compounds ’ toxicological risks and to guide legislation. Further studies on41 are warranted. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 26, 2018 Category: Forensic Medicine Source Type: research
Identifying exposures to ribosome-inactivating proteins in blood samples: amplification of ricin-induced ribosomal damage products enables sensitive detection of active toxin and circulating depurinated 28S rRNA
AbstractPurposeRicin, a highly potent plant-derived toxin, operates by site-specific depurination of ribosomes, which in turn leads to protein synthesis arrest. Recently, we presented the TRISOL [Truncated RNA Identification by Synthetic Oligonucleotide Ligation] method for the highly sensitive detection of exposures to type II ribosome-inactivating proteins such as ricin in clinical samples, based on the specific amplification of truncated cDNA molecules formed on ricin-dependent depurinated 28S rRNA templates. In the present study, we demonstrate the application of the TRISOL method to detect ricin exposure in blood samp...
Source: Forensic Toxicology - April 11, 2018 Category: Forensic Medicine Source Type: research
Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users
Conclusions2F-MT-45 has been detected in a seized tablet for the first time. The metabolite identification data provide useful urinary metabolite targets for forensic and clinical testing for MT-45 and allows screening of urine for 2F-MT-45 and its major metabolites to determine its prevalence in case work. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 5, 2018 Category: Forensic Medicine Source Type: research
