Development and application of a forensic toxicological library for identification of 56 natural toxic substances by liquid chromatography –quadrupole time-of-flight mass spectrometry
ConclusionsThis library will be more effective for the screening of natural toxic substances in routine forensic toxicological analysis. To our knowledge, there are no reports dealing with development of library for natural toxic substances by LC –QTOF-MS/MS. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 16, 2019 Category: Forensic Medicine Source Type: research
Assessment of the role played by n -propanol in distinction of ethanol source in postmortem blood with the assistance of ethyl glucuronide and ethyl sulfate
ConclusionsThe present study proved thatn-propanol was not a reliable marker for either putrefaction or ethanol source distinction by showing considerable false rate. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 12, 2019 Category: Forensic Medicine Source Type: research
Solid-phase extraction based on cation-exchange sorbents followed by liquid chromatography high-resolution mass spectrometry to determine synthetic cathinones in urine
ConclusionsThe results obtained enabled the studied compounds to be quantified at the usual levels at which they are present in urine samples. Moreover, these limits were lower than the ones found in the literature using similar extraction strategies, which shows that the reported strategy can be a useful tool in forensic and toxicological analyses. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 12, 2019 Category: Forensic Medicine Source Type: research
Hair testing for 3-fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC –MS/MS after unintentional overdose
ConclusionsWe report single or repetitive exposure to several fentanyls using hair testing. To our knowledge, this is the first demonstration of 3-fluorofentanyl and methoxyacetylfentanyl in hair samples collected from an authentic abuser. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 6, 2019 Category: Forensic Medicine Source Type: research
Surface adsorption of cannabinoids in LC –MS/MS applications
(Source: Forensic Toxicology)
Source: Forensic Toxicology - November 2, 2019 Category: Forensic Medicine Source Type: research
Targeting the administration of ecdysterone in doping control samples
ConclusionAn administration of ecdysterone can be targeted using existing procedures of anti-doping laboratories. Ecdysterone and desoxy-ecdysterone appeared as suitable candidates for integration in ITP. Using dilute-and-inject a detection of the parent compound was possible for more than 2 days after the administration of a single dose of ~ 50 mg. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 14, 2019 Category: Forensic Medicine Source Type: research
In vivo and in vitro metabolism of the novel synthetic cannabinoid 5F-APINAC
ConclusionsThe discovered metabolites are proposed to be incorporated into routine screening analytical methods as the urine markers of 5F-APINAC consumption. This is the first report to demonstrate the metabolism of 5F-APINAC to our knowledge. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 9, 2019 Category: Forensic Medicine Source Type: research
Identification of the designer benzodiazepine 8-chloro-6-(2-fluorophenyl)-1-methyl-4 H -[1,2,4]triazolo[4,3-a][1,4]benzodiazepine (flualprazolam) in an anesthesia robbery case
ConclusionsMore designer benzodiazepines have been detected and seized on the illegal drug scene as new psychoactive substances during the last 5 years. In this study, we presented analytical data of flualprazolam to assist forensic laboratories that encounter these newly emerging compounds in casework. This is the first report on this compound in illegal products. (Source: Forensic Toxicology)
Source: Forensic Toxicology - September 29, 2019 Category: Forensic Medicine Source Type: research
Worldwide poisoning potential of Brugmansia and Datura
ConclusionsAngel ’s trumpets have high toxicological significance both in their native and non-native regions, mainly due to their hallucinogenic property and accidental ingestion. (Source: Forensic Toxicology)
Source: Forensic Toxicology - September 6, 2019 Category: Forensic Medicine Source Type: research
In vitro toxicokinetics and analytical toxicology of three novel NBOMe derivatives: phase I and II metabolism, plasma protein binding, and detectability in standard urine screening approaches studied by means of hyphenated mass spectrometry
ConclusionsThe toxicokinetic data provided by this study will help forensic and clinical toxicologists to reliably identify these substances in case of abuse and/or intoxication and will allow them a thorough risk assessment. (Source: Forensic Toxicology)
Source: Forensic Toxicology - August 25, 2019 Category: Forensic Medicine Source Type: research
Determination of drug distributions in decomposed and buried postmortem tissues and bones of pigs administered of drugs
ConclusionsDrug distribution in organ and bone of decomposed and burial corpses vary due to unknown mechanisms and completely unexplained conditions such as postmortem redistribution. (Source: Forensic Toxicology)
Source: Forensic Toxicology - August 23, 2019 Category: Forensic Medicine Source Type: research
Antagonists for serotonin receptors ameliorate rhabdomyolysis induced by 25D-NBOMe, a psychoactive designer drug
ConclusionsOur findings suggest that multiple 5-HT receptors have important roles in NBOMes-induced rhabdomyolysis together with other serotonin-related symptoms. Zebrafish is a highly useful model for therapeutic studies of rhabdomyolysis induced by psychoactive designer drugs. (Source: Forensic Toxicology)
Source: Forensic Toxicology - August 18, 2019 Category: Forensic Medicine Source Type: research
A low-voltage paper spray ionization QTOF-MS method for the qualitative analysis of NPS in street drug blotter samples
ConclusionsThis technique was successfully applied for the analysis of NPS and allowed for fast and accurate analytical method that can be highly exploited in forensic screening purposes. (Source: Forensic Toxicology)
Source: Forensic Toxicology - August 18, 2019 Category: Forensic Medicine Source Type: research
Pharmacokinetics, pharmacodynamics, and toxicity of the new psychoactive substance 3,4-dimethylmethcathinone (3,4-DMMC)
ConclusionsThere is a wide scope to be explored on the effects of 3,4-DMMC. Clinicians and pathologists should be encouraged to report their findings in scientific literature, as this will aid in evaluating potential detrimental effects of the drug in further clinical and forensic investigations. Further studies on pharmacokinetic properties of 3,4-DMMC are also necessary to improve the methods of drug detection. (Source: Forensic Toxicology)
Source: Forensic Toxicology - August 5, 2019 Category: Forensic Medicine Source Type: research
Pharmacokinetic study of xylazine in a zebrafish water tank, a human-like surrogate, by liquid chromatography Q-Orbitrap mass spectrometry
ConclusionsXylazine was the subject of extensive metabolism in zebrafish. 4-Hydroxylated (M2) and oxygenated (M1) derivatives were the most abundant phase I metabolites as the main targets for doping control. (Source: Forensic Toxicology)
Source: Forensic Toxicology - July 30, 2019 Category: Forensic Medicine Source Type: research
