Identification of five mitragyna alkaloids in blood and tissues using liquid chromatography-quadrupole/time-of-flight mass spectrometry
ConclusionsA validated LC –Q/TOF–MS method for the analysis of fiveMitragyna alkaloids is described. In addition, minorMitragyna alkaloids and metabolites can serve as biomarkers of kratom use in blood and tissues. (Source: Forensic Toxicology)
Source: Forensic Toxicology - May 8, 2020 Category: Forensic Medicine Source Type: research
Development of a handy microdiffusion device using two plastic test tubes for accurately quantifying cyanide in blood
(Source: Forensic Toxicology)
Source: Forensic Toxicology - May 3, 2020 Category: Forensic Medicine Source Type: research
Drug levels in fatal cases where death was not directly attributable to drug toxicity
(Source: Forensic Toxicology)
Source: Forensic Toxicology - April 28, 2020 Category: Forensic Medicine Source Type: research
Matrix-assisted laser desorption/ionization in-source decay mass spectrometry analysis of human insulin and insulin analogues for the identification of insulin from insulin preparations
ConclusionsThe MALDI-ISD method is a rapid and convenient approach to identify human insulin and six insulin analogues that are components of all insulin preparations sold in Japan. In particular, this method can discriminate human insulin from insulin lispro, both of which have identical molecular weights, and therefore identifying them is difficult using conventional methods. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 23, 2020 Category: Forensic Medicine Source Type: research
Evaluation of carboxamide-type synthetic cannabinoids on the functional activities at cannabinoid receptors and biological effects via inhalation exposure test
ConclusionThis study provides information regarding the biological effects when smoking synthetic cannabinoids from the functional activities at the CB1 and CB2 receptors, considering their way of inhalation and thermal degradation. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 21, 2020 Category: Forensic Medicine Source Type: research
Postmortem histopathology and detection of venom by ELISA following suicide by cobra ( Naja kaouthia ) envenomation
ConclusionIn the absence of commercial kits for venom detection, confirmation of snake envenomation postmortem can be achieved by correlation of specific ELISA with local findings. Exclusion of related local snake venom is necessary to confirm the specificity of the assay. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 20, 2020 Category: Forensic Medicine Source Type: research
Comparative molecular networking analysis of a Rauwolfia plant powder and biological matrices in a fatal ingestion case
ConclusionsMolecular networking allowed us to discard theTabernanthe iboga identification hypothesis and suggest an alternateApocynaceae species, most likely belonging to theRauwolfia genus. In addition, eleven putative compounds could be detected by the molecular networking, many of which seemed to be metabolites of the major components in theRauwolfia genus. (Source: Forensic Toxicology)
Source: Forensic Toxicology - April 17, 2020 Category: Forensic Medicine Source Type: research
Sensitive determination of midazolam and propofol in human plasma by GC –MS/MS
ConclusionsIn this study, the authors have successfully established the detailed procedure for GC –MS/MS analysis of midazolam and propofol in human plasma. The sensitivity and specificity of the present method for the drugs were almost comparable to those by the standard liquid chromatography–tandem mass spectrometry. To their knowledge, this is the first report for analysis of midazolam/pr opofol by GC–MS/MS. (Source: Forensic Toxicology)
Source: Forensic Toxicology - March 31, 2020 Category: Forensic Medicine Source Type: research
25C-NBOMe short characterisation
ConclusionsOverall, findings show that 25C-NBOMe is a powerful hallucinogen. Easy online availability, low prize and the lack of knowledge of 25C-NBOMe makes this substance potentially very dangerous to its users. Thus, further investigation on the mechanism of action, chemical, pharmacological and toxicological properties is needed to evaluate 25C-NBOMe potential harmful effects. (Source: Forensic Toxicology)
Source: Forensic Toxicology - March 29, 2020 Category: Forensic Medicine Source Type: research
A fatal case of mexiletine intoxication in a 25-year-old Korean man
ConclusionsThe current result was determined to be a fatal overdose of mexiletine in a young Korean man withCYP2D6 homozygous for the wild allele. A genotyping of CYP2D6 may predict the fatal dose of mexiletine in individuals. (Source: Forensic Toxicology)
Source: Forensic Toxicology - March 18, 2020 Category: Forensic Medicine Source Type: research
A fatal case of aconite poisoning: accidental intake of a monkshood extract
ConclusionThe present case report emphasizes the danger of aconite extracts and presents results of the distribution of the alkaloid in the human body. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 26, 2020 Category: Forensic Medicine Source Type: research
Dispersive SPE, an alternative to traditional SPE for extraction of 43 doping peptides from equine urine prior to LC –MS screening
ConclusionsUsing dSPE as a clean-up method, 43 peptide analytes of interest were successfully screened by LC –MS/MS. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 24, 2020 Category: Forensic Medicine Source Type: research
The neurotoxicity of psychoactive phenethylamines “2C series” in cultured monoaminergic neuronal cell lines
ConclusionThe 2,5-dimethoxy-substitution of “2C series” induced severe neurotoxicity in both dopaminergic and serotonin-containing neurons. The non-toxic dose of MDMA or METH synergistically enhanced its neurotoxicity in serotonergic neurons. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 20, 2020 Category: Forensic Medicine Source Type: research
Spectroscopic and crystallographic characterization of a new cathinone derivative: 1-phenyl-2-(butylamino)hexan-1-one hydrochloride ( N -butylhexedrone)
ConclusionsIn this study, we presented chromatographic, spectroscopic and crystallographic characterization of a new cathinone derivative that emerged on the NPS market in 2019. The obtained analytical data should be useful for forensic and toxicological purposes in quick and reliable compound identification. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 10, 2020 Category: Forensic Medicine Source Type: research
Comparative neuropharmacological studies on three pyrrolidine-containing synthetic cathinones
ConclusionsPyrovalerone, 2,3-MDPV and 3,4-MDPV produced psychostimulant effects mediated by stimulation of dopaminergic neurotransmission. Additionally, all tested compounds elevated extracellular levels of 5-HT in vivo. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 31, 2020 Category: Forensic Medicine Source Type: research
