Sensitive quantitative analysis of psilocin and psilocybin in hair samples from suspected users and their distribution in seized hallucinogenic mushrooms
ConclusionsThe concentrations of psilocin in two authentic hair were 161 and 150 pg/mg, respectively, and psilocybin was not detected from both samples. This method was also used to analyze the distribution of psilocin and psilocybin in seven hallucinogenic mushrooms. To our knowledge, this is the first demonstration of psilocin concentrations in hair samples of hallucinogenic mushroom consumers, and also our method is most sensitive for quantitative analysis of psilocin and psilocybin in hair samples. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 2, 2021 Category: Forensic Medicine Source Type: research
A fluorine turns a medicinal benzodiazepine into NPS: the case of flualprazolam
ConclusionsThe recent flualprazolam-related cases have raised concerns to regulatory authorities and international stakeholders suggesting that flualprazolam should be under international control. The urgent international control of flualprazolam, despite the limited information on clinical effects and pharmacologic characteristics available, is an important measure for the prevention of its increasing abuse worldwide. (Source: Forensic Toxicology)
Source: Forensic Toxicology - February 2, 2021 Category: Forensic Medicine Source Type: research
Fatal intoxication with U-47700 in combination with other NPS ( N -ethylhexedrone, adinazolam, 4-CIC, 4-CMC) confirmed by identification and quantification in autopsy specimens and evidences
ConclusionsThe described case of fatal intoxication with NPS presented postmortem concentrations of U-47700, 4-CMC,N-ethylhexedrone, adinazolam and 4-CIC for the first time in the literature. The paper also showed stability study of these substances stored at + 4 °C for 775 days. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 19, 2021 Category: Forensic Medicine Source Type: research
A comparison between two different dried blood substrates in determination of psychoactive substances in postmortem samples
ConclusionsThis study proved that FTA cards are a good and a hazard-free alternative sample storage method for analysis of several psychoactive substances in postmortem blood. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 18, 2021 Category: Forensic Medicine Source Type: research
Counterfeit formulations: analytical perspective on anorectics
ConclusionsSlimming formulations doped with anorectic cocktails to boost their weight-reducing efficacy are not uncommon. Liquid chromatography combined with mass spectrometry remains the gold standard for counterfeit drug analysis, and requires improved preconcentration methods for rapid and quantitative identification of specific chemical constituents. Extensive method development and validation, targeted at refining existing techniques while developing new ones, is expected to improve the analytical profiling of counterfeit anorectics significantly. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 2, 2021 Category: Forensic Medicine Source Type: research
Discovering the major metabolites of the three novel fentanyl analogues 3-methylcrotonylfentanyl, furanylbenzylfentanyl, and 4-fluorocyclopropylbenzylfentanyl for forensic case work
ConclusionsIn the present study, we successfully discovered and elucidated the structures of the major metabolites of 3-MCF, FBF, and 4-FCBF which could be used as markers to confirm intake of these compounds in forensic case work. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 2, 2021 Category: Forensic Medicine Source Type: research
Identification and structure characterization of five synthetic opioids: 3,4-methylenedioxy-U-47700, o -methyl-acetylfentanyl, 2-thiophenefentanyl, benzoylfentanyl and benzoylbenzylfentanyl
ConclusionsComplementary LC –QTOF-MS/MS and NMR techniques enabled the unambiguous identification of new synthetic opioids. To the best of our knowledge, this is the first comprehensive characterization of these five NPS with complete data which are published to facilitate their detection and identification by forensic and c linical laboratories. (Source: Forensic Toxicology)
Source: Forensic Toxicology - January 1, 2021 Category: Forensic Medicine Source Type: research
Monitoring metabolism of synthetic cannabinoid 4F-MDMB-BINACA via high-resolution mass spectrometry assessed in cultured hepatoma cell line, fungus , liver microsomes and confirmed using urine samples
ConclusionsThe in-vitro models presented proved useful in the exhaustive metabolism studies. Despite limitations, HepG2 identified the major 4F-MDMB-BINACA ester hydrolysis metabolite, andC. elegans demonstrated the capacity to produce a wide variety of metabolites. BothC. elegans and HLM produced all the in-vivo metabolites. Ester hydrolysis and ester hydrolysis plus dehydrogenation 4F-MDMB-BINACA metabolites were recommended as urinary markers for 4F-MDMB-BINACA intake. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 29, 2020 Category: Forensic Medicine Source Type: research
Development and validation of quantitative analytical method for 50 drugs of antidepressants, benzodiazepines and opioids in oral fluid samples by liquid chromatography –tandem mass spectrometry
ConclusionsThe method was validated according to international recommendations for the 50 analytes, showing low limits of quantification, good imprecision and bias values, using simple liquid –liquid extraction, and was successfully applied to authentic oral fluid samples analysis. (Source: Forensic Toxicology)
Source: Forensic Toxicology - December 25, 2020 Category: Forensic Medicine Source Type: research
Potentially serious consequences for the use of Bitrex as a deterrent for the intentional inhalation of computer duster sprays
(Source: Forensic Toxicology)
Source: Forensic Toxicology - November 25, 2020 Category: Forensic Medicine Source Type: research
Identification of six tryptamine derivatives as designer drugs in illegal products
ConclusionsThe continuous provisional monitoring of newly detected compounds in illicit products will largely prevent the distribution of these products. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 24, 2020 Category: Forensic Medicine Source Type: research
Is COVID-19 the current world-wide pandemic having effects on the profile of psychoactive substance poisonings?
(Source: Forensic Toxicology)
Source: Forensic Toxicology - November 8, 2020 Category: Forensic Medicine Source Type: research
Rapid identification of Colchicum autumnale based on loop-mediated isothermal amplification (LAMP) assay
ConclusionsThe currently proposed protocol exhibits good potential as a screening method forC. autumnale poisoning in emergency medical care. (Source: Forensic Toxicology)
Source: Forensic Toxicology - November 4, 2020 Category: Forensic Medicine Source Type: research
Quantification of 5F-CUMYL-P7AICA in blood and urine from an authentic fatality associated with its consumption by UHPLC –MS/MS
ConclusionsThe developed method enabled for determination of 5F-CUMYL-P7AICA in human blood and urine with high sensitivity and selectivity. To our knowledge, this is the first report to quantify 5F-CUMYL-P7AICA in blood and urine of an authentic case with full validation. (Source: Forensic Toxicology)
Source: Forensic Toxicology - October 20, 2020 Category: Forensic Medicine Source Type: research
DNA testing of suspected cannabis samples with exceptional morphology using a simple detection kit
ConclusionsAlthough the quality of the DNA used as PCR template needs to be considered, simple DNA testing with a kit is very effective for identifying suspected cannabis samples with exceptional morphology. (Source: Forensic Toxicology)
Source: Forensic Toxicology - September 30, 2020 Category: Forensic Medicine Source Type: research
