Human phase I metabolism of the novel synthetic cannabinoid 5F-CUMYL-PEGACLONE

Conclusions5F-CUMYL-PEGACLONE was subject to extensive metabolism in humans. The propionic acid metabolite was the most abundant metabolite in all urine samples and should be targeted when maximum sensitivity is needed (e.g., drug abstinence control). However, this metabolite also occurs in the biotransformation of the non-fluorinated analog and is, therefore, not a compound-specific marker. For differentiation, a metabolite hydroxylated at theγ-carbolinone core showed to be the most reliable marker and should be used as an additional target analyte.
Source: Forensic Toxicology - Category: Forensic Medicine Source Type: research