Update on adrenal cortical neoplasia
The adrenal cortex gives rise to a biologically heterogenous group of neoplasms, each with a with distinct morphology, antigen expression and molecular profile. Adrenal cortical adenomas have excellent prognosis and are usually cured by surgical resection alone, while adrenal cortical carcinomas are very aggressive tumors with a poor prognosis regardless of therapy. These tumors are rare and often challenging for a pathologist to diagnose, as significant overlap exists between benign and malignant lesions in some cases. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 8, 2021 Category: Pathology Authors: Andrey Prilutskiy, V ânia Nosé Tags: Mini-symposium: Endocrine pathology Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 31, 2021 Category: Pathology Source Type: research
Primary pigmented nodular adreno-cortical disease
Cushing's syndrome can cause significant morbidity; effective treatment requires integrated clinical, biochemical, and radiological assessments to reach an accurate diagnosis. Primary pigmented nodular adreno-cortical disease (PPNAD) is an uncommon cause of ACTH-independent Cushing's. Diagnosis can be challenging, in particular where the radiological findings are normal or suggestive of a unilateral process. The condition is very commonly associated with Carney complex and referral for evaluation by a clinical genetics team is essential. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 30, 2021 Category: Pathology Authors: John Connelly, Morna MacNeill Tags: Short Case Source Type: research
Anaplastic thyroid carcinoma: diagnostic challenges, histopathologic features and ancillary testing
This article describes the clinical, histopathologic and molecular features of ATC and also addresses the associated diagnostic limitations and challenges. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 29, 2021 Category: Pathology Authors: Syed M. Gilani, Muhammad Khan, Andrea Barbieri, Manju L. Prasad Tags: Mini-symposium: Endocrine pathology Source Type: research
H ürthle cell neoplasms
H ürthle cells (HC) are characterized by abundant granular eosinophilic cytoplasm containing accumulated dysfunctional mitochondria and large nuclei with prominent nucleoli. Based on the distinct clinicopathologic and molecular characteristics of Hürthle cell neoplasms (HCN), the 2017 Endocrine Worl d Health Organization (WHO) moved to categorizing HCN as a separate group of tumors. Hürthle cell carcinomas (HCC) are now subclassified as minimally invasive, encapsulated angioinvasive, and widely invasive. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 27, 2021 Category: Pathology Authors: Stephanie Siegmund, I ñigo Landa, Kristine S. Wong, Justine A. Barletta Tags: Mini-symposium: Endocrine pathology Source Type: research
Kinase fusion-related thyroid carcinomas: distinct pathologic entities with evolving diagnostic implications
Activating genomic alterations in protein kinases represent a major driving force in thyroid carcinogenesis. Recently, oncogenic kinase fusions have been a central subject of pharmaceutical development, with a rapidly growing number of inhibitors validated for treating molecularly matched malignancies. Thyroid carcinomas harbor actionable kinase fusions in 10 –15% of cases, occupying an increasingly recognized subpopulation of thyroid carcinomas with enhanced attention to molecular profiling. With advances in kinase-based cancer therapy, several challenges have emerged for pathologists. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 27, 2021 Category: Pathology Authors: Ying-Hsia Chu, Peter M. Sadow Tags: Mini-symposium: Endocrine pathology Source Type: research
Lymphoreticular pathology of the head and neck region: a review of selected entities
In routine surgical pathology lymphoid proliferations are seen fairly frequently. It is important to be aware of commonly seen reactive and inflammatory pathologies, as well as malignant lymphomas of the MALT tissue and nodal involvement by lymphomas. Several of the reactive pathologies have striking morphological features such that haematoxylin and eosin stained slides are sufficient in arriving at a diagnosis. There are several pathological entities in which Ebstein-Barr virus has a role to play, including both benign and malignant proliferations. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 9, 2021 Category: Pathology Authors: Sanjay Jogai Tags: Mini-symposium: Head and neck pathology Source Type: research
Condylomata lata of the oral commissure: an unexpected presentation of secondary syphilis
We present the case of a 33 year-old male presenting with a white lesion within the left oral commissure. The lesion was initially regarded as either smoker's keratosis or verrucous hyperplasia and was biopsied to exclude a neoplasm. Histology revealed squamous epithelial hyperplasia, plasmacytic inflammation and neuritis. Treponema immunohistochemistry demonstrated the presence of spirochetes and subsequent serology confirmed the diagnosis as syphilis. The oral commissure is an unusual site for secondary syphilis (condylomata lata). (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 7, 2021 Category: Pathology Authors: Luke Farmkiss, Vincent Shadrick, Tim Bracey Tags: Mini-Symposium: Head and Neck Pathology Source Type: research
Ear and temporal bone pathology: is anything new?
The ear and temporal bone are a challenging areas for the diagnostic pathologist. The anatomy is complex and lesions may be small and relatively inaccessible. Many tumours occurring at this site are rarely encountered. Biopsy tissue samples may be crushed, small and often associated with bone, which complicates processing. Correlation with imaging is essential and interpretation often requires specialist expertise. In this article selected lesions are discussed in order to illustrate diagnostic difficulty the surgical pathologist encounters with small biopsies and on approaching the cut up of complex resection specimens fr...
Source: Diagnostic Histopathology - March 4, 2021 Category: Pathology Authors: Ann Sandison, Robert Kennedy Tags: Mini-symposium: Head and neck pathology Source Type: research
An overview and update on bone lesion in craniofacial bones
Pathologists infrequently see cases of bone tumours, which are rare entities, and their diagnosis is challenging. To achieve the correct diagnosis and for patients to be offered optimal treatment, it is critical that a multidisciplinary specialised team is involved. The last decade has seen exceptional advances in the molecular classification of bone tumours, which have not only made reaching diagnoses easier, but also makes the subspeciality an exciting area of research. Bone tumours are classified based on their histological features, irrespective of the anatomical site in which the tumour presents; however, not every tu...
Source: Diagnostic Histopathology - March 4, 2021 Category: Pathology Authors: Calum Connolly, Vaishnavi Sabarigirivasan, Lucia Cottone, Adrienne M. Flanagan, Roberto Tirabosco Tags: Mini-symposium: Head and neck pathology Source Type: research
An overview and update on soft tissue lesions of the head and neck
Soft tissue lesions of the head and neck encompass a broad range of pathological entities associated with different prognoses and requiring different treatments. All pathologists will encounter a wide range of soft tissue tumours in whatever specialist area they practice. Getting the diagnosis ‘right the first time’ is critical for patients to be offered optimal treatment. Molecular testing can help reach the correct diagnoses and this arena is developing fast. However, pathologists should not rely unquestioningly on special tests, whether it is immunohistochemistry or whole genome se quencing as no test is entirely sp...
Source: Diagnostic Histopathology - March 3, 2021 Category: Pathology Authors: Emily Hepburn, Mathew D'Costa, Lucia Cottone, Adrienne M. Flanagan, Roberto Tirabosco Tags: Mini-symposium: Head and neck pathology Source Type: research
Pseudomalignancies of the head and neck
Pseudomalignancies are benign or reactive lesions that mimic malignant neoplasms either clinically or histologically. In the head and neck region there are a number of pseudomalignancies that may present to a histopathologist, including soft tissue lesions, benign odontogenic tumours and salivary gland pathology. In this review we discuss common pseudomalignant lesions that may present in the head and neck, including their clinical presentation, histopathological features and differential diagnosis. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 3, 2021 Category: Pathology Authors: Hannah Crane, Hannah Walsh, Artysha Tailor, Keith Hunter Tags: Mini-symposium: Head and neck pathology Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 1, 2021 Category: Pathology Source Type: research
The histopathology of proliferative verrucous leukoplakia
Proliferative verrucous leukoplakia (PVL) is a chronic, aggressive oral mucosal condition with a poor long-term prognosis. It has no specific, defining microscopic characteristics and is a clinical rather than histological diagnosis. PVL may appear clinicopathologically innocuous in its early stages, but there are clues that can alert the histopathologist to a dangerous condition, such as the recognition of hyperkeratoses which, though apparently benign, are inconsistent with well-defined reactive entities. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 25, 2021 Category: Pathology Authors: A William Barrett Tags: Mini-symposium: Head and neck pathology Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 1, 2021 Category: Pathology Source Type: research
