Three rare cases of benign mixed tumour of the skin displaying mature bone and cartilage elements
We present three rare cases of mixed tumour of the skin. Two of these displayed both mature bone and cartilaginous mesenchymal elements, while the third displayed mature bone formation without cartilage. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - June 22, 2023 Category: Pathology Authors: Kieran P. Shotton, Ali Al-Omari Tags: Short case Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 27, 2023 Category: Pathology Source Type: research
Training in post-mortem pathology
A degree of post-mortem training is currently a requirement for every histopathology trainee within the United Kingdom. The expectation is that all trainees should be able to eviscerate and perform basic systematic organ examinations in a variety of straightforward cases to identify common causes of death. Those who are interested in pursuing further training may opt into the Royal College of Pathologists Higher Post-mortem training module. Becoming adept at post-mortem practice is challenging without access to an adequate number of a range of cases, high quality trainers, and a well-structured and supportive learning envi...
Source: Diagnostic Histopathology - May 13, 2023 Category: Pathology Authors: Nataliya Piletska, Lucia Molinengo, Daniel Nash, Michael Osborn Tags: Mini-symposium: autopsy pathology Source Type: research
A case of parathyroid carcinoma discovered at post-mortem
We present a post-mortem (PM) case of a patient who died from complications of a previously undiagnosed parathyroid carcinoma (PC). The typical clinical signs and symptoms are highlighted. The histology of PC is reviewed, and we discuss the key genetic alterations, and hereditary conditions, in which it is typically seen. Trainees should be aware of the findings of PC that may be encountered at PM, as well as the implications of PC for surviving first degree family members. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 9, 2023 Category: Pathology Authors: Dilek Taze, Hannah Hawrot Tags: Short case Source Type: research
The Medical Examiner: reviewing all non-coronial deaths in England and Wales
The role of Medical Examiner was originally introduced in England and Wales by the Coroners and Justice Act 2009. A key aim is to ensure that concerns about the care of the deceased by families and whistle-blowers are identified and acted upon, to avoid repeated community and hospital-based care scandals. Since 2019 all acute hospital trusts have established their own Medical Examiner Service which is tailored to local needs and systems under the guidance of the National Medical Examiner. Medical Examiners are independent, senior, registered medical practitioners whose role is to ensure accuracy of the Medical Certificate ...
Source: Diagnostic Histopathology - May 4, 2023 Category: Pathology Authors: Suzy Lishman, Jason Payne-James Tags: Mini-symposium: autopsy pathology Source Type: research
The future of the autopsy: will nano-robots replace pathologists?
This article discusses the potential of current and future technological developments, alongside some changes to systems of death investigation and employment arrangements that could establish autopsy practice as a professionalised service and a sought after career choice. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 2, 2023 Category: Pathology Authors: Esther Youd Tags: Mini-symposium: autopsy pathology Source Type: research
Approach to the autopsy examination of an adult decomposing body
Whilst it may be unpleasant, the autopsy examination of decomposing bodies is a rewarding task that will usually reveal the cause of death when performed with care. After death, the body undergoes a series of putrefactive decompositional changes in a predictable order, unless conditions favouring desiccation/mummification or adipocere formation intervene. All three decompositional changes may be present in the same body. Determining the postmortem interval in such bodies is fraught with difficulty. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 29, 2023 Category: Pathology Authors: Julian Burton Tags: Mini-symposium: autopsy pathology Source Type: research
The molecular-morphologic correlates of bladder cancer
Environmental exposure to carcinogens trigger molecular events that lay the background for the subsequent development of urothelial carcinoma from the basal and intermediate layers of urothelial lining. Clinical classes of non-muscle invasive bladder cancer and muscle invasive bladder cancer are broadly divided into basal and luminal subtypes each with their molecular, morphologic and outcome characteristics. Morphology of cancer represents the sum total of genetic and epigenetic changes. The current review highlights the molecular – morphologic correlates identifiable in our daily clinical practice, the knowledge of whi...
Source: Diagnostic Histopathology - April 28, 2023 Category: Pathology Authors: Priti Lal Tags: Mini-symposium: Updates in genitourinary pathology Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 26, 2023 Category: Pathology Source Type: research
Histopathologic approaches to the infiltrative renal mass
Most renal masses are round or oval, well-circumscribed, and demonstrate a well-defined interface from the normal renal parenchyma. However, a small subset of renal tumors exhibits an infiltrative pattern, with a poorly-defined interface with the renal parenchyma and entrapment of normal structures. These infiltrative renal malignancies generally show more aggressive clinical course and are associated with a poorer prognosis compared to the more typical renal neoplasms. Main differential diagnoses for a renal mass with infiltrative histology would include urothelial carcinoma, fumarate hydratase (FH)-deficient renal cell c...
Source: Diagnostic Histopathology - April 26, 2023 Category: Pathology Authors: Nicole Zalles, Jane K. Nguyen, Sean R. Williamson Tags: Mini-symposium: Updates in genitourinary pathology Source Type: research
Pathology updates and diagnostic approaches to hemophagocytic lymphohistiocytosis
Hemophagocytic lymphohistiocytosis (HLH) is a complex, often under-recognized hyperinflammatory immune dysregulation syndrome arising in a diverse range of clinical scenarios and conditions. The accurate and timely diagnosis of HLH is crucial for patient survival, and usually requires a high level of clinical suspicion. The histologic corollary to clinical HLH – hemophagocytosis – is neither necessary or sufficient for the diagnosis of HLH, as it may be seen in a variety of reactive conditions, or may be absent in true HLH. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 12, 2023 Category: Pathology Authors: Alexander Kikuchi, Kunwar Singh, Eric Gars, Robert S. Ohgami Tags: Mini-symposium: lymphoreticular pathology Source Type: research
Primary adenocarcinoma of the bladder: a rare primary bladder tumour type
Primary bladder adenocarcinoma is rare and metastatic or locally invasive adenocarcinomas from other organs are more frequently seen within the bladder. Here we present a 61-year-old patient with an adenocarcinoma within the bladder neck. It was a diagnostic challenge to differentiate between primary bladder adenocarcinoma, metastatic colorectal adenocarcinoma, and prostatic adenocarcinoma. After extensive immunohistochemistry the diagnosis of primary bladder adenocarcinoma was made. We discuss how to come to this diagnosis and what immunohistochemistry approaches can be taken to differentiate it from other adenocarcinomas...
Source: Diagnostic Histopathology - April 12, 2023 Category: Pathology Authors: Kate Marks, Alireza Behzadnia, Jo-An Roulson Tags: Short case Source Type: research
A case of comma-shaped fibrillary glomerulonephritis
We present a case of a 77-year-old male with multiple co-morbidities who underwent a renal biopsy for progressive loss of renal function. Examination by electron microscopy revealed glomerular deposits within which were numerous randomly orientated 22 nanometre mean diameter curvilinear fibrils, consistent with a rare form of fibrillary glomerulonephritis. Review of the literature has revealed just one similar case. The investigative work up and histological findings are discussed along with the clinical implications of making a diagnosis of fibrillary glomerulonephritis. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 5, 2023 Category: Pathology Authors: Katie Hoyles, Bart E. Wagner, Ali Al-Omari, Adam Shardlow, Eu-wing Toh, Anna Takou Tags: Short case Source Type: research
The 2022 World Health Organization classification of germ cell tumors and updates of American Joint Committee for Cancer tumor staging classification
Testicular tumors are most common in young men between 15 and 45 years of age. Germ cell tumors make up the biggest proportion of malignant tumors of the testis. Due to the diverse morphologic spectrum and overlapping morphologies, it is a very challenging area in the anatomic pathology field, which needs significant expertise and experience to render a precise diagnosis. The World Health Organization (WHO) has recently presented a new tumor classification with significant modifications in nomenclature as well as some refinement of criteria. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 31, 2023 Category: Pathology Authors: Irem Kilic, Muhammad T. Idrees Tags: Mini-symposium: Updates in genitourinary pathology Source Type: research
An update on atypical large glandular proliferations of the prostate
The differential diagnosis of prostatic atypical large gland proliferations includes several benign and malignant entities. This review focusses on issues relevant to the practising pathologist, particularly around areas of controversy such as high-grade prostatic intraepithelial neoplasia (HGPIN) and intraductal carcinoma of the prostate (IDCP). HGPIN is a putative precursor of prostate cancer, but its clinical relevance is as a surrogate marker of unsampled prostate cancer, thereby identifying patients who would benefit from a prompt repeat biopsy. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 30, 2023 Category: Pathology Authors: Murali Varma Tags: Mini-symposium: Updates in genitourinary pathology Source Type: research
