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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - June 30, 2021 Category: Pathology Source Type: research
A case of eosinophilic solid and cystic renal cell carcinoma-emerging entity
Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a recently described distinct and unique renal neoplasm that was originally described in female patients with tuberous sclerosis complex but now shown to occur mostly in a sporadic form with a female predominance. They result from somatic loss of TSC1 or TSC2 tumour suppressor genes. These tumours typically show a solid and cystic architecture, and the neoplastic cells are characterized by abundant granular eosinophilic cytoplasm with most showing a characteristic basophilic cytoplasmic stippling. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - June 29, 2021 Category: Pathology Authors: Olaleke Oluwasegun Folaranmi, Olabode Ali Odetunde, Ademola Popoola Tags: Short case Source Type: research
Current concepts in the classification of thoracic neuroendocrine tumours
Bronchopulmonary neuroendocrine tumours (NETs) share features with extrathoracic NETs and comprise a spectrum of neuroendocrine neoplasms, most of which are also mirrored by counterparts in the thymus. Accurate classification remains difficult on morphological criteria alone, as overlapping and transitional phenotypes occur and reproducibility of classification is marred by ambiguity, heterogeneity and sampling error, and artefacts, especially in cytology and small biopsy specimens. While there have been significant advances in the immunohistochemical and molecular characterization and phenotyping of thoracic NETs in recen...
Source: Diagnostic Histopathology - June 7, 2021 Category: Pathology Authors: Jan von der Th üsen Tags: Mini-symposium: Cardiothoracic pathology Source Type: research
Update on mesothelioma diagnosis and classification
Significant progress in the diagnosis and classification of pleural mesothelioma has been made in the past 5 years. Novel biomarkers are now entering more widespread use following major advances in understanding the genomic landscape of the malignancy. As the diagnosis and management of mesothelioma becomes more multidisciplinary together with the increasing role of histopathology in providing additional prognostic information to guide downstream management, we review herein newly proposed prognostic variables, diagnostic biomarkers, utility of pleural effusion cytology in diagnosis, and mesothelioma surgery. (Source: Diag...
Source: Diagnostic Histopathology - June 5, 2021 Category: Pathology Authors: Yu Zhi Zhang, Cecilia Brambilla, Andrew G. Nicholson Tags: Mini-symposium: Cardiothoracic pathology Source Type: research
Congenital lung disease: multiple entities you may not have encountered
Congenital lung disease comes to the attention of the surgical pathologist through lung biopsy or excision of a lung lobe. The two most frequent clinical indications are removal of a mass, often detected antenatally, or investigation of difficulty in ventilation or oxygenation. The diagnostic possibilities in each instance are different. The mass is most commonly a cystic airway malformation, but a limited number of rare neoplasms enters the differential diagnosis. Biopsy in the case of difficulty in ventilation most often shows delayed alveolar development, but surfactant protein disorder and a small number of lethal deve...
Source: Diagnostic Histopathology - June 3, 2021 Category: Pathology Authors: Michael T. Ashworth, J. Ciaran Hutchinson, Mohammad Haini Tags: Mini-symposium: Cardiothoracic pathology Source Type: research
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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - June 1, 2021 Category: Pathology Source Type: research
A very rare case of synchronous primary lung cancer lymph node metastasis
A 76 year old patient presented with two synchronous primary lung tumours. One was identified as an adenocarcinoma and the second as an atypical carcinoid tumour. When reviewing the lymph node slides it was seen that one lymph node contained metastatic deposits from both primary tumours. Synchronous lung tumours are fairly rare occurrences, but even rarer is the finding of synchronous metastases to the same lymph node. The atypical carcinoid deposit was very subtle in appearance and could easily have been overlooked. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 25, 2021 Category: Pathology Authors: Kate Marks, Radhika Ramnath Tags: Short Case Source Type: research
Emerging spectrum of COVID-19-related cardiopulmonary pathology in adults
This article aims to acquaint the general histopathologist with the main pathological findings in the lungs and heart of adults with COVID-19. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 19, 2021 Category: Pathology Authors: Brian Hanley, Melanie Jensen, Michael Osborn Source Type: research
Clinical utility of pathology data: prostate and kidney cancer
Cancer pathology reports can be complex due to multiple data elements, variability in terminology, and increasing recognition of emerging diagnostic entities. However, treatment may be significantly influenced by histologic subtype, histologic grade, and pathologic tumor stage. We review the clinical utility of pathology data for prostate and kidney cancers, with emphasis on main decision-making points. Key parameters that affect management of prostate cancer in the biopsy setting include Grade Group, percentage of pattern 4, and sometimes extent of involvement. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 18, 2021 Category: Pathology Authors: Jane K. Nguyen, Jesse K. McKenney, Sean R. Williamson Tags: Mini-symposium: uropathology reporting: communication and clinical utility of data Source Type: research
Clinical utility of histopathology data: cancers of the testis and urinary bladder
Histopathology data form the basis of most oncological patient management. Pathology guidelines therefore recommend sets of core data items that should be reported in each specimen. The clinical utility of a particular data item depends on the clinical scenario. Awareness of how these data are used to guide patient management could enable pathologists to focus their resources on clinically important issues. For example, it is generally critical to identify even a minor nonseminomatous component in a predominantly seminomatous testicular germ cell tumour as such patients would be managed as a nonseminoma. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 13, 2021 Category: Pathology Authors: Ronald CK. Chan, Ashish Chandra, Murali Varma Tags: Mini-symposium: uropathology reporting: communication and clinical utility of data Source Type: research
RBM10-TFE3 renal cell carcinoma: the role of tissue morphology and molecular diagnostics
We present a diagnostic case for which a next-generation RNA sequencing approach confirmed the presence of a RBM10-TFE3 fusion transcript. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 7, 2021 Category: Pathology Authors: Benjamin R. Challoner, Steven Hazell Tags: Short case Source Type: research
Pathology reporting: communication is key
Guidelines generally focus on complete reporting of histopathology data in a standard format. We highlight the importance of effectively communicating the “message” to clinicians who do not view histology images. Communication issues related to each part of the histopathology report are outlined. We emphasize that reports must be unambiguous and include only relevant information so that the latter is not misunderstood or missed by the treating cli nician. The specimen block key should be available to reporting and reviewing pathologists but does not have to be included in the report communicated to the clinical team. (...
Source: Diagnostic Histopathology - May 5, 2021 Category: Pathology Authors: Adam Christian, Varsha I. Shah Tags: Mini-Symposium: Uropathology Reporting: Communication and Clinical Utility of Data Source Type: research
Personalized histopathology reporting for personalized medicine
Guidelines focus on the accurate, reproducible and complete recording of histopathology data items, that they generally categorize as either core (mandatory) or non-core (recommended but not mandatory). We highlight some issues with this traditional approach and describe an approach focusing on the clinical utility of histopathology data and the importance of effectively communicating this data to the clinical team. A data item that is critical in one clinical scenario may be clinically irrelevant in another setting. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 4, 2021 Category: Pathology Authors: Anita M. Borges, Murali Varma Tags: Mini-Symposium: Uropathology Reporting: Communication and Clinical Utility of Data Source Type: research
Communicating prostate biopsy results
We describe a different approach focusing on optimising communication of histopathological parameters such as tumour extent and grade to the clinical team. Communication is crucial because clinicians usually do not view histological material and are dependent on the information included in the histopathology report. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 3, 2021 Category: Pathology Authors: Murali Varma, Anne Y. Warren, Brett Delahunt Tags: Mini-symposium: uropathology reporting: communication and clinical utility of data Source Type: research
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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - April 29, 2021 Category: Pathology Source Type: research
