A case of eosinophilic solid and cystic renal cell carcinoma-emerging entity

Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a recently described distinct and unique renal neoplasm that was originally described in female patients with tuberous sclerosis complex but now shown to occur mostly in a sporadic form with a female predominance. They result from somatic loss of TSC1 or TSC2 tumour suppressor genes. These tumours typically show a solid and cystic architecture, and the neoplastic cells are characterized by abundant granular eosinophilic cytoplasm with most showing a characteristic basophilic cytoplasmic stippling.
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Short case Source Type: research