Log in to search using one of your social media accounts:

 

Study identifies tools to identify patients at risk for autism spectrum disorders
(Cincinnati Children's Hospital Medical Center) A tool intended to detect signs of autism in high-risk infants can be used to help identify and treat patients with tuberous sclerosis complex, a genetic disorder, who most need early intervention. Moreover, they can identify these patients earlier than ever before. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 17, 2017 Category: International Medicine & Public Health Source Type: news

Long-Lasting Effect of Everolimus in Tuberous Sclerosis Long-Lasting Effect of Everolimus in Tuberous Sclerosis
Researchers observe effects that seem to improve the longer the drug is taken in an open-label extension of the phase 2 EXIST-3 trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 11, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Self-injury and aggression in adults with tuberous sclerosis complex: frequency, associated person characteristics, and implications for assessment - Wilde L, Eden K, de Vries P, Moss J, Welham A, Oliver C.
Even though self-injury and aggression are common in tuberous sclerosis complex (TSC), understanding of these behaviours in adults with TSC and intellectual disability (ID) is limited. Little is known about their frequency in comparison to other ID-related... (Source: SafetyLit)
Source: SafetyLit - April 17, 2017 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news

New cause of brain defects in tuberous sclerosis complex
A new molecular pathway that inhibits the myelination of neurons in the brains of patients with the rare genetic disorder tuberous sclerosis complex (TSC) has been discovered by researchers. The study suggests new ways to treat some of the neurological symptoms associated with TSC, including autism and epilepsy. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 9, 2017 Category: Science Source Type: news

Novartis says Votubia receives EU approval for new indication
ZURICH (Reuters) - Novartis has broadened the indications for its Votubia drug, the company said on Tuesday, when the European Union approved its use to treat refractory partial-onset seizures in patients with tuberous sclerosis complex. (Source: Reuters: Health)
Source: Reuters: Health - January 31, 2017 Category: Consumer Health News Tags: healthNews Source Type: news

Findings in tuberous sclerosis complex on the role of inflammation and epilepsy
(US Department of Defense Congressionally Directed Medical Research Programs) Dr. Wong focused on ECG treatment in the mice and found that treatment did minimally correct some of the brain tissue abnormalities seen in the mouse model, but, more importantly, there was a small decrease in seizure development and slightly improved survival in these mice. Dr. Wong and his laboratory have provided a proof-of-concept preclinical study suggesting that anti-inflammatory treatment could be a potential therapy for epilepsy in TSC patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 19, 2016 Category: Global & Universal Source Type: news

Sirolimus Gel for Tuberous Sclerosis Facial Angiofibromas Sirolimus Gel for Tuberous Sclerosis Facial Angiofibromas
A topical sirolimus gel is safe and effective for treating facial angiofibromas in patients with tuberous sclerosis complex (TSC), Japanese researchers report.Reuters Health Information (Source: Medscape Dermatology Headlines)
Source: Medscape Dermatology Headlines - November 23, 2016 Category: Dermatology Tags: Hematology-Oncology News Source Type: news

EXIST-3: Everolimus Decreases Seizures in Tuberous Sclerosis EXIST-3: Everolimus Decreases Seizures in Tuberous Sclerosis
Calling the study'ground-breaking,'one expert says the results'nail down'important issues involved in targeting tuberous sclerosis seizures'with a rational, pathophysiological approach. 'Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 10, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Drug reduces seizure frequency in children with tuberous sclerosis complex
(Cincinnati Children's Hospital Medical Center) In an international study, the drug everolimus has been shown to significantly reduce the frequency of seizures in patients with treatment-resistant epilepsy and tuberous sclerosis complex (TSC) -- a genetic disease that causes malformations and tumors in the brain and other vital organs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 6, 2016 Category: Cancer & Oncology Source Type: news

Research note: Yale team provides new insight into intractable epilepsy
One of the major causes of intractable epilepsy is a malformation of brain development that occurs in individuals with focal cortical dysplasia or tuberous sclerosis complex. These malformations are marked by misplaced and abnormally large neurons in focal cortical brain regions. However, a Yale team led by Angelique Bordey and Lawrence S. Hsieh developed a new mouse model of focal cortical malformation that showed neuronal misplacement is not required to trigger seizures. Instead, large misshapen neurons by themselves can generate seizures, according to the study published June 1 in the journal Nature Communications. The ...
Source: Yale Science and Health News - June 2, 2016 Category: Universities & Medical Training Tags: Yale News Source Type: news

Everolimus May Have Activity in Seizure Disorder
(MedPage Today) -- Drug reduced seizure frequency in tuberous sclerosis compared with placebo (Source: MedPage Today Meeting Coverage)
Source: MedPage Today Meeting Coverage - April 22, 2016 Category: Journals (General) Source Type: news

Everolimus Data for Seizures in Tuberous Sclerosis 'Exciting'Everolimus Data for Seizures in Tuberous Sclerosis 'Exciting'
The new results may open the door to eventually being able to treat epilepsy, not just seizures, researchers say. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - April 21, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

GW Pharmaceuticals initiates Phase 3 study of Epidiolex for TSC disorder
GW Pharmaceuticals has started a Phase 3 clinical trial of Epidiolex as an adjunctive therapy for treatment of seizures related to tuberous sclerosis complex (TSC), a rare genetic disorder where the most common symptom is epilepsy. (Source: Drug Development Technology)
Source: Drug Development Technology - April 11, 2016 Category: Pharmaceuticals Source Type: news

GW Pharmaceuticals Initiates Phase 3 Pivotal Study in Tuberous Sclerosis Complex
LONDON, April 11, 2016 -- (Healthcare Sales & Marketing Network) -- GW Pharmaceuticals plc (GWPH) (GWP.L) (“GW” or “the Company”), a biopharmaceutical company focused on discovering, developing and commercializing novel therapeutics from its proprietary ca... Biopharmaceuticals, NeurologyGW Pharmaceuticals, Epidiolex, cannabidiol, Tuberous Sclerosis Complex (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 11, 2016 Category: Pharmaceuticals Source Type: news

Cancer study is 'paradigm shift' in cause of tumor formation
A gene that may provide a new source of potential drug targets for tumors that arise in pulmonary tuberous sclerosis complex (TSC) has been found by a pair of investigators. The discovery may change what is known about tumor formation and help to slow or halt tumor growth, therefore having broader implications in cancer research. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 17, 2016 Category: Science Source Type: news

Blanket forts, healthy hearts and life: What our families are thankful for
When parents and children first arrive at our front door — no matter why or from where they come — they forever become part of our extended family. On this Thanksgiving, just like the 47 million others who are traveling to see loved ones, we too packed up the car and drove to visit 11 of the families who have stayed with us at Boston Children’s over the years. We wanted to find out what they were most thankful for and what makes this season special to them. Thank you to the families of Ella S., Julian, Ella D., Addison, Callum, Nora, Avery, Jace, Molly, Charlotte, Murphy and Robbie for welcoming us i...
Source: Thrive, Children's Hospital Boston - November 26, 2015 Category: Pediatrics Authors: Jenny Fernandez Tags: All posts Thanksgving Source Type: news

Everolimus Results Improve for SEGA in Tuberous Sclerosis Everolimus Results Improve for SEGA in Tuberous Sclerosis
The EXIST-1 extension trial shows that rates of response to treatment with everolimus improved after 4 years in patients with subependymal giant cell astrocytoma associated with tuberous sclerosis complex. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - November 2, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

For children with rare genetic disorder, more extensive epilepsy surgery yields better seizure control
(Wolters Kluwer Health) Children with the genetic disorder tuberous sclerosis complex often need epilepsy surgery for severe, uncontrollable seizures. A new study finds that seizure control is improved for patients undergoing more extensive surgery, reports the October issue of Neurosurgery, official journal of the Congress of Neurological Surgeons, published by Wolters Kluwer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 20, 2015 Category: Global & Universal Source Type: news

Management of renal angiomyolipomas in TSC
mTOR inhibition is likely to transform management of tuberous sclerosis complex and the results of landmark trials are being studied to see if the encouraging reductions in tumour size translate into improved outcomes for patients in the long term (Source: Pharmacy Europe)
Source: Pharmacy Europe - October 16, 2015 Category: Drugs & Pharmacology Authors: ebercott Tags: Featured Articles Source Type: news

For children with rare genetic disorder, more extensive epilepsy surgery yields better seizure control
Children with the genetic disorder tuberous sclerosis complex (TSC) often need epilepsy surgery for severe, uncontrollable seizures. A new study finds that seizure control is improved for patients undergoing more extensive surgery. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 15, 2015 Category: Science Source Type: news

[RS Housden] Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
Combining targeted CRISPR-mediated gene editing with an RNAi-mediated screen identifies candidate drug targets. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 9, 2015 Category: Science Authors: Benjamin E. Housden, Alexander J. Valvezan, Colleen Kelley, Richelle Sopko, Yanhui Hu, Charles Roesel, Shuailiang Lin, Michael Buckner, Rong Tao, Bahar Yilmazel, Stephanie E. Mohr, Brendan D. Manning, Norbert Perrimon Source Type: news

Topical timolol reduces facial angiofibromas in tuberous sclerosis
Topical beta-blockers could be an alternative to rapamycin for the treatment of angiofibromas after traditional destructive procedures such as ablative laser resurfacing, according to a case study published in the Aug. 24 edition of Pediatrics. A 26-year-old woman with tuberous sclerosis complex... (Source: Skin and Allergy News)
Source: Skin and Allergy News - August 24, 2015 Category: Dermatology Source Type: news

Jim Carrey Apologizes For Tweeting Photo Of Boy With Autism In Anti-Vaccine Rant
Jim Carrey spent Tuesday evening and Wednesday morning tweeting about his anti-vaccination views, and on Thursday night he apologized for including a photo of a young boy without permission. The actor had sent out an image of the boy, who has autism, as part of a series of tweets challenging a new California law that eliminates personal-belief exemptions for childhood immunizations. The mother of Alex Echols asked Carrey to remove the photo of her son, noting that he had not been given permission to use it. @JimCarrey Please remove this photo of my son. You do not have permission to use his image.— Karen Echols (@...
Source: Science - The Huffington Post - July 3, 2015 Category: Science Source Type: news

Jim Carrey Apologizes For Tweeting Photo Of Boy With Autism In Anti-Vaccine Rant
Jim Carrey spent Tuesday evening and Wednesday morning tweeting about his anti-vaccination views, and on Thursday night he apologized for including a photo of a young boy without permission. The actor had sent out an image of the boy, who has autism, as part of a series of tweets challenging a new California law that eliminates personal-belief exemptions for childhood immunizations. The mother of Alex Echols asked Carrey to remove the photo of her son, noting that he had not been given permission to use it. @JimCarrey Please remove this photo of my son. You do not have permission to use his image.— Karen Echols...
Source: Healthy Living - The Huffington Post - July 3, 2015 Category: Consumer Health News Source Type: news

Jim Carrey Apologizes For Tweeting Photo Of Boy With Autism In Anti-Vaccine Rant
Jim Carrey spent Tuesday evening and Wednesday morning tweeting about his anti-vaccination views, and on Thursday night he apologized for including a photo of a young boy without permission. The actor had sent out an image of the boy, who has autism, as part of a series of tweets challenging a new California law that eliminates personal-belief exemptions for childhood immunizations. The mother of Alex Echols asked Carrey to remove the photo of her son, noting that he had not been given permission to use it. @JimCarrey Please remove this photo of my son. You do not have permission to use his image.— Karen Echols (@...
Source: Healthy Living - The Huffington Post - July 3, 2015 Category: Consumer Health News Source Type: news

May highlights: Overcoming brain hemorrhage, brachial plexus + more
Catch up on what you may have missed on Thriving last month. Our staff takes a look back at a few of this month’s favorite posts. A sister’s words: The athlete who couldn’t be tamed by a brain hemorrhage Carly is a superstar athlete, running a 5:32 mile at the young age of 14. Her heroes include Tom Brady, Malcolm Butler and Boston Children’s neurosurgeon Dr. Ed Smith. After emergency surgery to repair a brain hemorrhage Carly’s career aspirations have shifted, and the Cape Cod track star is now pondering the world of neurosurgery. Read A sister’s words: The athl...
Source: Thrive, Children's Hospital Boston - June 1, 2015 Category: Pediatrics Authors: Lisa Fratt Tags: Our patients’ stories brachial plexus brain hemorrhage melanoma tuberous sclerosis Source Type: news

Tuberous sclerosis: Clinical trial may be what halted Charlotte’s seizures
Charlotte with Jurriaan Peters, MD, in the Clinical and Translational Study Unit. When Charlotte D’Amario was about 4½ months old, she began making odd, forward-lurching movements. At first, her pediatrician thought it was reflux—that she was trying to spit up. “It was getting worse and worse, and no one had a clue as to what it was,” says Allyson, her mother. Her parents started to videotape her while she made these odd motions. They occurred in clusters of as many as 50 at a time, several times a day. Seeing videos of Charlotte at 8½ months, her pediatrician sent her to a neurologist...
Source: Thrive, Children's Hospital Boston - May 15, 2015 Category: Pediatrics Authors: Nancy Fliesler Tags: All posts Diseases & conditions Our patients’ stories Research Tests & treatment epilepsy seizures TSC tuberous sclerosis complex Source Type: news

Poirot's David Suchet reveals fight for NHS drugs to help grandson
The TV star has criticised 'disorganisation' in the NHS for slowing down the process for better treatment for his grandson, Todd, who has the rare condition Tuberous Sclerosis Complex. (Source: the Mail online | Health)
Source: the Mail online | Health - April 2, 2015 Category: Consumer Health News Source Type: news

133 Organizations Ask Congress to Close the Innovation Deficit
Dear Member of Congress: The 133 undersigned national business, higher education, scientific, patient, and other organizations write to strongly urge you to pass an omnibus FY2015 appropriations bill this year that includes increased investments in scientific research and higher education needed to help close our nation's innovation deficit. Members of the Senate and House from both political parties have highlighted the need to address the innovation deficit. Congress has already taken some preliminary steps in this direction. In most instances, individual appropriations bills considered by the House and Senate Appropri...
Source: ActionBioscience - November 12, 2014 Category: Science Authors: Julie Palakovich Carr Source Type: news

133 Organizations Ask Congress to Close the Innovation Deficit
Dear Member of Congress: The 133 undersigned national business, higher education, scientific, patient, and other organizations write to strongly urge you to pass an omnibus FY2015 appropriations bill this year that includes increased investments in scientific research and higher education needed to help close our nation's innovation deficit. Members of the Senate and House from both political parties have highlighted the need to address the innovation deficit. Congress has already taken some preliminary steps in this direction. In most instances, individual appropriations bills considered by the House and Senate Appropri...
Source: ActionBioscience - November 12, 2014 Category: Biology Authors: Julie Palakovich Carr Source Type: news

Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers - Eden KE, de Vries PJ, Moss J, Richards C, Oliver C.
BACKGROUND: Research reporting prevalence rates of self-injurious and aggressive behaviour in people with tuberous sclerosis complex (TSC) is limited. No studies have compared rates of these behaviours in TSC with those in other syndrome groups matched for... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - May 17, 2014 Category: Global & Universal Tags: Age: Adolescents Source Type: news

Sunlight exposure may cause skin tumour development in TSC
UV rays in sunlight cause DNA damage and sun exposure is a major risk factor in most skin cancers. A recent study from Harvard suggests that sun exposure may also worsen the number and severity of skin lesions found in tuberous sclerosis patients (Tyburczy et al., 2013)12/23/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - December 23, 2013 Category: Cancer & Oncology Source Type: news

Study points to possible treatment for brain disorders
Clemson University scientists are working to determine how neurons are generated, which is vital to providing treatment for neurological disorders like Tuberous Sclerosis Complex (TSC). TSC is a rare genetic disease that causes the growth of tumors in the brain and other vital organs and may indicate such disorders as autism, epilepsy and cognitive impairment that may arise from the abnormal generation of neurons... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 24, 2013 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news

Clemson University study points to possible treatment for brain disorders
(Clemson University) Clemson University scientists are working to determine how neurons are generated, which is vital to providing treatment for neurological disorders like Tuberous Sclerosis Complex. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 22, 2013 Category: Global & Universal Source Type: news

What Neoplasms are Patients with Neurofibromatosis At Risk For?
Discussion Neurofibromatosis Type 1 (NF1) is one of many neurocutaneous diseases with a probable underestimated incidence of 1:3000. Also called phacomatoses, a review can be found at: What is the Epidemiology and Genetics of the Major Phacomatoses? The key elements of NF1 are: Neurofibromatosis Type 1 Epidemiology: 1:2500-3000 – most common phacomatosis Genetics: autosomal dominant with variable penetrance, associated with chromosome 17 Neurological: various central nervous system tumors especially neurofibromas (often benign but may act malignant because of location or size, tumors may also degenerate into a mal...
Source: PediatricEducation.org - September 23, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

What Neoplasms are Patients with Neurofibromatosis At Risk For?
Discussion Neurofibromatosis Type 1 (NF1) is one of many neurocutaneous diseases with a probable underestimated incidence of 1:3000. Also called phacomatoses, a review can be found at: What is the Epidemiology and Genetics of the Major Phacomatoses? The key elements of NF1 are: Neurofibromatosis Type 1 Epidemiology: 1:2500-3000 – most common phacomatosis Genetics: autosomal dominant with variable penetrance, associated with chromosome 17 Neurological: various central nervous system tumors especially neurofibromas (often benign but may act malignant because of location or size, tumors may also degenerate into a mal...
Source: PediatricEducation.org - September 23, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Upstate Golisano Children’s Hospital is first to treat rare brain tumor with multi-staged approach using laser ablation technology
Dr. Zulma Tovar-Spinoza, director of Pediatric Neurosurgery at Upstate Golisano Children's Hospital, and her team are the first physicians in the world to use this approach in treating tuberous sclerosis, which causes non-cancerous tumors. (Source: SUNY Upstate Medical)
Source: SUNY Upstate Medical - September 20, 2013 Category: Universities & Medical Training Source Type: news

Tuberous Sclerosis Complex-Associated Kidney AngiomyolipomaTuberous Sclerosis Complex-Associated Kidney Angiomyolipoma
How and why do tuberous sclerosis complex-associated kidney angiomyolipomas develop, and what are the possible surgical and medical therapies available to treat them? Nephrology Dialysis Transplantation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 4, 2013 Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

Autism has 'eerie' connection to cancer gene
Autism also occurs in about half of kids with a genetic disorder known as tuberous sclerosis, which boosts brain and kidney cancer risk.08/13/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - August 13, 2013 Category: Cancer & Oncology Source Type: news

Drug Shows Dramatic Reduction In Seizures In Patients With Tuberous Sclerosis Complex
Further Studies Could Determine Benefit to Epilepsy Patients Without TSC A drug originally developed to prevent the rejection of transplanted organs has now been shown to dramatically reduce seizures in patients with tuberous sclerosis complex (TSC) - a genetic disease characterized by benign tumors on multiple organ systems. TSC is estimated to affect more than a million individuals throughout the world. The study is the latest to demonstrate the effectiveness of everolimus for TSC patients... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 16, 2013 Category: Consumer Health News Tags: Epilepsy Source Type: news

Drug shows dramatic reduction in seizures in patients with tuberous sclerosis complex
(Cincinnati Children's Hospital Medical Center) A drug originally developed to prevent the rejection of transplanted organs has now been shown to dramatically reduce seizures in patients with tuberous sclerosis complex -- a genetic disease characterized by benign tumors on multiple organ systems. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 15, 2013 Category: Global & Universal Source Type: news

Tuberous Sclerosis Brain Science
Doctors often diagnose tuberous sclerosis complex (TSC) based on the abnormal growths the genetic disease causes in organs around the body. Those overt anatomical structures, however, belie the microscopic and mysterious neurological differences behind the disease's troublesome behavioral symptoms: autism, intellectual disabilities, and seizures. In a new study in mice, Brown University researchers highlight a role for a brain region called the thalamus and show that the timing of gene mutation during thalamus development makes a huge difference in the severity of the disease... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 13, 2013 Category: Consumer Health News Tags: Autism Source Type: news

Advance in tuberous sclerosis brain science
(Brown University) By manipulating the timing of disease-causing mutations in the brains of developing mice, Brown University researchers have found that early genetic deletions in the thalamus may play an important role in course and severity of the developmental disease tuberous sclerosis complex. Findings appear in the journal Neuron. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 9, 2013 Category: Global & Universal Source Type: news

Tuberous Sclerosis Diagnosed by Incidental CT FindingsTuberous Sclerosis Diagnosed by Incidental CT Findings
In this unusual case of tuberous sclerosis complex, there were none of the classic clinical findings. What did CT reveal that suggested the diagnosis? Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 25, 2013 Category: Consumer Health News Tags: Radiology Journal Article Source Type: news

13-year-old tuberous sclerosis patient with renal cell carcinoma
We report a 13-year-old white girl with epilepsy and hypopigmented skin lesions...02/05/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 5, 2013 Category: Cancer & Oncology Source Type: news

How Common Are Skeletal Problems in Neurofibromatosis Patients?
Discussion Neurofibromatosis Type 1 (NF1) is one of many neurocutaneous diseases. Also called phacomatosis, a review can be found at: What is the Epidemiology and Genetics of the Major Phacomatoses? The key elements of NF1 and 2 are: Neurofibromatosis Type 1 Epidemiology: 1:2500-3000 – most common phacomatosis Genetics: autosomal dominant with variable penetrance, associated with chromosome 17 Neurological: various central nervous system tumors especially neurofibromas (often benign but may act malignant because of location or size, tumors may also degenerate into a malignant variant or cause other problems such a...
Source: PediatricEducation.org - February 4, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

Everolimus treatment option for tuberous sclerosis patients
Researchers have shown that the immunosuppressant everolimus provides a potential new treatment option for patients with tuberous sclerosis and associated angiomyolipomas. (Source: MedWire News - Urology)
Source: MedWire News - Urology - January 25, 2013 Category: Urology & Nephrology Source Type: news

Everolimus Reduces Size of Noncancerous Kidney Tumors
The mTOR inhibitor everolimus (Afinitor) has been found to significantly reduce the size of angiomyolipomas, the slow-growing benign tumors commonly associated with tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis, according to the results of the phase III EXIST-2 study. (Source: Cancer Network)
Source: Cancer Network - January 16, 2013 Category: Cancer & Oncology Source Type: news

Afinitor® in patients with non-cancerous tumours
Data published in The Lancet has shown that patients on Afinitor® (everolimus) tablets with non-cancerous kidney tumours known as renal angiomyolipomas associated with tuberous sclerosis complex (TSC) experienced a significant reduction in tumour size and the absence of tumour progression (Source: Pharmacy Europe)
Source: Pharmacy Europe - January 11, 2013 Category: Drugs & Pharmacology Source Type: news

Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): RCT
Source: Lancet Area: News Tuberous sclerosis is a rare debilitating disease affecting one in 5800 livebirths and fewer than one million people worldwide. It is associated with multiple lesions including renal angiomyolipoma, brain subependymal giant-cell astrocytomas, and pulmonary lymphangioleiomyomatosis. Angiomyolipomas are slow-growing tumours, which predispose patients to serious complications including retroperitoneal haemorrhage and impaired renal function. The condition is caused by mutations in either TSC1 or TSC2 suppressor genes, resulting in increased mTOR activity. Hence, mTOR inhibitors have a rationale for ...
Source: NeLM - News - January 11, 2013 Category: Drugs & Pharmacology Source Type: news