Everolimus Reduces Size of Noncancerous Kidney Tumors
The mTOR inhibitor everolimus (Afinitor) has been found to significantly reduce the size of angiomyolipomas, the slow-growing benign tumors commonly associated with tuberous sclerosis complex (TSC) and sporadic lymphangioleiomyomatosis, according to the results of the phase III EXIST-2 study. (Source: Cancer Network)
Source: Cancer Network - January 16, 2013 Category: Cancer & Oncology Source Type: news
Afinitor® in patients with non-cancerous tumours
Data published in The Lancet has shown that patients on Afinitor® (everolimus) tablets with non-cancerous kidney tumours known as renal angiomyolipomas associated with tuberous sclerosis complex (TSC) experienced a significant reduction in tumour size and the absence of tumour progression (Source: Pharmacy Europe)
Source: Pharmacy Europe - January 11, 2013 Category: Drugs & Pharmacology Source Type: news
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): RCT
Source: Lancet
Area: News
Tuberous sclerosis is a rare debilitating disease affecting one in 5800 livebirths and fewer than one million people worldwide. It is associated with multiple lesions including renal angiomyolipoma, brain subependymal giant-cell astrocytomas, and pulmonary lymphangioleiomyomatosis. Angiomyolipomas are slow-growing tumours, which predispose patients to serious complications including retroperitoneal haemorrhage and impaired renal function. The condition is caused by mutations in either TSC1 or TSC2 suppressor genes, resulting in increased mTOR activity. Hence, mTOR inhibitors have a rationale for ...
Source: NeLM - News - January 11, 2013 Category: Drugs & Pharmacology Source Type: news
Kidneys sometimes removed unnecessarily due to misdiagnosis of genetic disorder
Thousands of individuals have had kidneys removed unnecessarily because doctors misdiagnosed their disease. A new study indicates that approximately one of every five individuals with kidney tumors common in patients with tuberous sclerosis complex, a genetic disorder, has had a kidney removed. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 11, 2013 Category: Science Source Type: news
Kidneys Sometimes Removed Needlessly in Patients with Rare Genetic Disorder
Tuberous sclerosis causes benign growths to form on organs that doctors can mistake for cancer
Source: HealthDay
Related MedlinePlus Pages: Benign Tumors, Kidney Diseases, Tuberous Sclerosis (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - January 11, 2013 Category: Consumer Health News Source Type: news
Votubia® (everolimus) Provides A Non-invasive Alternative To Surgery In Patients With Kidney Tumours Associated With Tuberous Sclerosis Complex (T
Everolimus, a once daily pill that blocks the mTOR pathway, can reduce the size of non-cancerous kidney tumours1 and is licensed today in the UK. Previously embolisation or surgery has been the only option for Tuberous Sclerosis Complex patients with kidney tumours... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 8, 2013 Category: Consumer Health News Tags: Tuberculosis Source Type: news
Spontaneous Primary Pneumothorax
Authors: V. Mundra, M.D., J. Zapatier, M.D., H. Feiz, M.D., Cleveland Clinic FloridaReviewer: V. Dimov, M.D., University of ChicagoA 16-year-old male patient came to the emergency department with complaints of shortness of breath and chest pain which started one day ago. The shortness of breath was mild in severity, made worse by exertion and relieved with rest, associated with pleuritic chest pain, left sided, 5-6/10, sharp in nature. He denied any similar symptoms in the past.Past medical, social, surgical and family historyHe also denied any use of illicit drug like cocaine or and any history of trauma. He did not have ...
Source: Clinical Cases and Images - August 24, 2009 Category: General Medicine Tags: Critical Care Pulmonology Source Type: news
Neurology: Images in Clinical Medicine
Editor: V. Dimov, M.D., Cleveland ClinicHypoglossal Nerve Palsy during Meningococcal Meningitis. NEJM, 10/2014.Absent Superficial Abdominal Reflex due to thoracic spinal cord neuromyelitis. NEJM, 05/2014.Kayser-Fleischer Rings in Wilson ' s Disease. NEJM, 03/2012.Perilymph Fistula Test leads to nystagmus. NEJM, 01/2012.A stray bullet in the brain - with no deficit of power, cognition, sense of touch, or speech. Lancet, 01/2012.Blindness after Fat Injections. NEJM, 12/2011.Internal-Carotid-Artery Dissection and Cranial-Nerve Palsies. NEJM, 12/2011.A Head Shot. NEJM, 12/2011.Multiple Intracranial Tuberculomas. NEJM, 10/2011....
Source: Clinical Cases and Images - August 22, 2009 Category: General Medicine Tags: Images Neurology Source Type: news
Novartis kidney cancer drug clears key hurdle
Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR Results of RECORD-1 trial address unmet medical need in renal cell cancer withworldwide regulatory filings planned for second half of 2008 Complete results to be submitted as l...
Source: Kidney Cancer Association - February 28, 2008 Category: Urology & Nephrology Source Type: news
Novartis kidney cancer drug clears key hurdle
Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy
Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus
Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR
Results of RECORD-1 trial address unmet medical need in renal cell cancer with worldwide regulatory filings planned for second half of 2008
Complete res...
Source: Kidney Cancer Association - February 28, 2008 Category: Urology & Nephrology Source Type: news
Novartis kidney cancer drug clears key hurdle
Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR Results of RECORD-1 trial address unmet medical need in renal cell cancer withworldwide regulatory filings planned for second half of 2008 Complete results to be submitted as l...
Source: Kidney Cancer Association - February 28, 2008 Category: Urology & Nephrology Source Type: news
