KEYNOTE-028 Trial Unveils Biomarkers Linked to Pembrolizumab Efficacy
The results of the study add to the growing body of literature regarding potential biomarkers for response to immune checkpoint inhibitors. (Source: Cancer Network)
Source: Cancer Network - January 16, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

New Second-Line Option for Advanced Gastric Cancer
The results of a phase III randomized trial found that the anti-angiogenesis antibody ramucirumab improved survival in advanced, previously treated gastric cancer. (Source: Cancer Network)
Source: Cancer Network - October 9, 2013 Category: Cancer & Oncology Source Type: news

ECC: Ipilimumab Provides 10-Year Survival in Some Melanoma Patients
Patients with advanced melanoma treated with ipilimumab may be able to survive up to 10 years, according to the results of a study presented at the 2013 European Cancer Congress. (Source: Cancer Network)
Source: Cancer Network - October 8, 2013 Category: Cancer & Oncology Source Type: news

ECC: Everolimus Effective in Advanced Papillary Renal Cell Carcinoma
The mTOR inhibitor everolimus showed clinical efficacy for the initial treatment of advanced papillary renal cell carcinoma, according to the phase II results of the RAPTOR trial. (Source: Cancer Network)
Source: Cancer Network - October 8, 2013 Category: Cancer & Oncology Source Type: news

Tracking Nausea/Vomiting in Diary Helped Health Care Team Reduce Symptoms
Asking patients to track their nausea and vomiting after a course of chemotherapy helped the health care team to adjust medications and achieve better control of symptoms, according to the results of a small single center study. (Source: Cancer Network)
Source: Cancer Network - October 7, 2013 Category: Cancer & Oncology Source Type: news

ECC: T-DM1 May Be New Standard of Care in Heavily Pretreated Advanced Breast Cancer
T-DM1, a combination drug of trastuzumab and a cell-killing drug emtansine, significantly improved progression-free survival in women with advanced HER2-positive breast cancer whose cancer has recurred or progressed despite previous treatments, according to the results of the TH3RESA trial. (Source: Cancer Network)
Source: Cancer Network - October 4, 2013 Category: Cancer & Oncology Source Type: news

Role of BRAF in Papillary Thyroid Carcinoma Still Unclear
A new study of the relationship between BRAF V600E mutation status and its effect on papillary thyroid carcinoma found a negative association with clinicopathologic features suggestive of more aggressive disease. (Source: Cancer Network)
Source: Cancer Network - October 4, 2013 Category: Cancer & Oncology Source Type: news

ECCO 2013: Diabetes Increased Risk for Developing, Dying from Breast or Colon Cancer
A new meta-analysis indicated that people with diabetes are not only at an increased risk of developing breast and colon cancer, but are also at an increased risk of dying from the diseases. (Source: Cancer Network)
Source: Cancer Network - October 4, 2013 Category: Cancer & Oncology Source Type: news

Antidepressants Could Treat Small-Cell Lung Cancer
Researchers used an unbiased bioinformatics approach to identify a class of drugs currently used for non-cancer treatment that could be used to treat small-cell lung cancer, a cancer type for which there are few treatment options. (Source: Cancer Network)
Source: Cancer Network - October 3, 2013 Category: Cancer & Oncology Source Type: news

ECC: Diabetes Increased Risk for Developing, Dying from Breast or Colon Cancer
A new meta-analysis indicated that people with diabetes are not only at an increased risk of developing breast and colon cancer, but are also at an increased risk of dying from the diseases. (Source: Cancer Network)
Source: Cancer Network - October 3, 2013 Category: Cancer & Oncology Source Type: news

Dose-Dense Anthracycline Safe With Anti-HER2 Drugs
Long-term safety and efficacy results of two phase II trials indicate that dose-dense anthracycline-based chemotherapy with doxorubicin and cyclophosphamide can be safely combined with anti-HER2 therapy in women with early breast cancer. (Source: Cancer Network)
Source: Cancer Network - October 3, 2013 Category: Cancer & Oncology Source Type: news

Anti-depressants Could Treat Small-Cell Lung Cancer
Researchers used an unbiased bioinformatics approach to identify a class of drugs currently used for non-cancer treatment that could be used to treat small-cell lung cancer, a cancer type for which there are few treatment options. (Source: Cancer Network)
Source: Cancer Network - October 3, 2013 Category: Cancer & Oncology Source Type: news

ECC: Hyperfractionated Radiotherapy Improved Survival for Head and Neck Cancers
The use of altered fractionation radiotherapy increased overall survival in patients with locally advanced head and neck cancers when compared with standard radiation, according to the results of a meta-analysis presented on Saturday at the 2013 European Cancer Congress in Amsterdam. (Source: Cancer Network)
Source: Cancer Network - October 2, 2013 Category: Cancer & Oncology Source Type: news

Comprehensive Map Shows Role of Viruses Among 19 Cancers
Taking advantage of the copious amounts of data generated from The Cancer Genome Atlas (TCGA), researchers have created a comprehensive map of the viruses present in a wide range of cancer types. (Source: Cancer Network)
Source: Cancer Network - October 2, 2013 Category: Cancer & Oncology Source Type: news

Denosumab Most Effective in High-Risk Prostate Cancer Patients
The anti-RANKL antibody denosumab is more effective for preventing bone metastasis in men with high-risk castration-resistant prostate cancer compared with low-risk disease, according to results of a new study. (Source: Cancer Network)
Source: Cancer Network - October 2, 2013 Category: Cancer & Oncology Source Type: news

ECCO 2013: Hyperfractionated Radiotherapy Improved Survival for Head and Neck Cancers
The use of altered fractionation radiotherapy increased overall survival in patients with locally advanced head and neck cancers when compared with standard radiation, according to the results of a meta-analysis presented on Saturday at the 2013 European Cancer Congress in Amsterdam. (Source: Cancer Network)
Source: Cancer Network - October 2, 2013 Category: Cancer & Oncology Source Type: news

Slide Show: Medullary Thyroid Carcinoma
This thyroid cancer slide show features pathology images of medullary thyroid carcinomas showing amyloid deposits, solid components, spindle cell growth pattern, and papillary and neuroendocrine features. (Source: Cancer Network)
Source: Cancer Network - October 1, 2013 Category: Cancer & Oncology Source Type: news

Proteins Marker Could Identify Aggressive Lung Cancers
A specific pair of proteins more often found in aggressive smoking-related lung adenocarcinomas could serve as a prognostic biomarker for aggressive disease. (Source: Cancer Network)
Source: Cancer Network - October 1, 2013 Category: Cancer & Oncology Source Type: news

FDA Approves Pertuzumab for Neoadjuvant HER2-positive Breast Cancer
The U.S. Food and Drug Administration (FDA) today granted pertuzumab (Perjeta) accelerated approval for the treatment of patients with HER2-positive early stage breast cancer prior to surgery who are at high risk for recurrence or metastasis. (Source: Cancer Network)
Source: Cancer Network - October 1, 2013 Category: Cancer & Oncology Source Type: news

Panobinostat Recaptured Response in Bortezomib-Refractory Myeloma Patients
The addition of the oral pan-deacetylase inhibitor panobinostat to bortezomib helped to elicit responses in about one-third of heavily pre-treated patients with multiple myeloma who were refractory of bortezomib, according to the phase II results of the PANORAMA 2 study. (Source: Cancer Network)
Source: Cancer Network - September 30, 2013 Category: Cancer & Oncology Source Type: news

Evidence for Improved Patient Quality of Life With Prostate Cancer Drug
Abiraterone acetate in combination with prednisone delays pain progression as well as health-related quality of life compared with prednisone alone in prostate cancer patients, a new study shows. (Source: Cancer Network)
Source: Cancer Network - September 30, 2013 Category: Cancer & Oncology Source Type: news

Early Tumor Shrinkage in Colorectal Cancer Suggests Long-Term Cetuximab Benefit
Colorectal cancer patients who have early tumor shrinkage after first-line treatment with chemotherapy plus cetuximab may be more likely to have long-term response to therapy, according to an analysis of two large clinical trials. (Source: Cancer Network)
Source: Cancer Network - September 29, 2013 Category: Cancer & Oncology Source Type: news

Hospice Care Is Part of Oncology Practice
Why do doctors have such a hard time embracing hospice care and using it to benefit patients, particularly oncology patients? Referring a patient to a hospice program starts a sophisticated plan of care wholly directed at patient comfort, education of the family and grief counseling for the family. (Source: Cancer Network)
Source: Cancer Network - September 27, 2013 Category: Cancer & Oncology Source Type: news

Slide Show: Small-Cell Lung Cancer, Mesothelioma, and Thymoma
This lung cancer slide show features pathology images of small-cell lung carcinoma, neuroendocrine carcinomas, mesothelioma, and thymoma. (Source: Cancer Network)
Source: Cancer Network - September 26, 2013 Category: Cancer & Oncology Source Type: news

PI3KCA Could Predict Aspirin Response in Colorectal Cancer
In the VICTOR trial, patients with PI3KCA-positive colorectal cancer who took aspirin had a lower cancer recurrence compared to those with a wild-type PI3KCA gene. (Source: Cancer Network)
Source: Cancer Network - September 26, 2013 Category: Cancer & Oncology Source Type: news

Right Kidney Mass Found in 52-Year-Old Patient
A 52-year-old man presents with symptoms of hematuria. A mass in the right kidney is found on imaging studies. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - September 25, 2013 Category: Cancer & Oncology Source Type: news

A 60-Year-Old Patient Presents With Acute Abdominal Pain
A 60-year-old woman on anticoagulation for a lower extremity deep vein thrombosis presents with acute abdominal pain. A non-contrast CT scan is performed. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - September 25, 2013 Category: Cancer & Oncology Source Type: news

A Visit to the Oncologist—in 2057
I am seriously thinking about firing my oncology software. It has been 19 months now since I found myself stuck with this relapse. I don’t dare tell my father anything yet—he’ll start going on about how I should see a human doctor. He has been pushing me to visit a LiveDoc who supposedly is still practicing oncology in midtown. Right—like I’m going to do that. (Source: Cancer Network)
Source: Cancer Network - September 25, 2013 Category: Cancer & Oncology Source Type: news

Shorter High-Dose Radiotherapy Effective for Breast Cancer
Ten-year follow up two large randomized trials in the UK show that less frequent but higher dose radiotherapy regimen are as safe and effective as the standard regimen of more frequent lower doses for women with early breast cancer post-surgery. (Source: Cancer Network)
Source: Cancer Network - September 24, 2013 Category: Cancer & Oncology Source Type: news

FDG-PET May Help Predict Lung Cancer Survival
Analysis of 18F FDG-PET standardized uptake values may be a useful technique for predicting survival in patients with inoperable stage III non–small-cell lung carcinoma, according to a new study. (Source: Cancer Network)
Source: Cancer Network - September 23, 2013 Category: Cancer & Oncology Source Type: news

Skin Lesions on a 12-Year-Old Patient
A 12-year-old boy presents with numerous itchy skin lesion on his arms. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - September 23, 2013 Category: Cancer & Oncology Source Type: news

Married Individuals Less Likely to Be Diagnosed With Advanced Cancer
A large study shows a difference in the cancer outcomes of married and unmarried individuals, finding that those who are married are less likely to be diagnosed with metastatic disease and to die of their cancer compared with those who are unmarried. (Source: Cancer Network)
Source: Cancer Network - September 23, 2013 Category: Cancer & Oncology Source Type: news

Impact of Screening on Early- and Late-Stage Colorectal Cancers
A study on screening colonoscopy for colorectal cancers, originally presented at ASCO 2013, found that from 1976 to 2009 late-stage cancer incidence decreased from 117 to 74 cases per 100,000 people, and early-stage incidence decreased from 77 to 68 cases per 100,000. (Source: Cancer Network)
Source: Cancer Network - September 22, 2013 Category: Cancer & Oncology Source Type: news

Inherited Mutation Linked to Development of Pediatric ALL
A mutation of the PAX5 gene has been found to play an important role in inherited cases of B-cell precursor acute lymphoblastic leukemia (B-ALL). The mutation was isolated in two unrelated families with high propensity for B-ALL. (Source: Cancer Network)
Source: Cancer Network - September 21, 2013 Category: Cancer & Oncology Source Type: news

FDA Priority Review for Metastatic Melanoma Oral Combination
The combination of two oral targeted agents, dabrafenib (Tafinlar) and trametinib (Mekinist), has been given a priority review by the FDA for the treatment of BRAF V600-positive metastatic melanoma. (Source: Cancer Network)
Source: Cancer Network - September 20, 2013 Category: Cancer & Oncology Source Type: news

No Survival Benefit With Ipilimumab in Advanced Prostate Cancer
In a phase III trial, ipilimumab increased the overall survival of men with advanced castration-resistant prostate cancer when used with a single dose of radiotherapy by 1.2 months, but the results were not statistically significant. (Source: Cancer Network)
Source: Cancer Network - September 20, 2013 Category: Cancer & Oncology Source Type: news

Vaccination Shows No Benefit for Primary Melanomas
The use of GM2-KLH/QS-21 vaccination in stage II melanoma patients did not improve outcomes, according to the results of the EORTC 18961 phase III trial. (Source: Cancer Network)
Source: Cancer Network - September 19, 2013 Category: Cancer & Oncology Source Type: news

Chemo Education Classes Empower Patients
At ONS Congress 2013, Peggy Scott explains how chemotherapy education classes at The Emily Couric Cancer Center, now in place for 2 years, have put patients at the center of their care and prepared them to start treatment (abstract 129532). (Source: Cancer Network)
Source: Cancer Network - September 19, 2013 Category: Cancer & Oncology Source Type: news

A 63-Year-Old Patient Presents With Significant Dyspnea
A 63-year-old woman comes to your office with significant dyspnea. You obtain a chest x-ray which is shown here. What is the best next step in management? (Source: Cancer Network)
Source: Cancer Network - September 19, 2013 Category: Cancer & Oncology Source Type: news

NDA Filed for Idelalisib for Treating Non-Hodgkin Lymphoma
Gilead Sciences has submitted an NDA to the FDA for its new drug idelalisib, for the use in patients with indolent non-Hodgkin lymphoma that is refractory to rituximab and chemotherapy. (Source: Cancer Network)
Source: Cancer Network - September 18, 2013 Category: Cancer & Oncology Source Type: news

Nurse-Led Care Coordination After Colorectal Cancer Surgery Failed to Show Effect
The use of a centralized nurse-led telephone-based care coordination system failed to improve outcomes including quality of life, unmet supportive needs or visits to the emergency department after surgical resection of colorectal cancer, according to the results of a new study. (Source: Cancer Network)
Source: Cancer Network - September 18, 2013 Category: Cancer & Oncology Source Type: news

MicroRNAs Regulate Small-Cell Lung Cancer Bone Metastasis
Researchers have identified a novel pathway that promotes bone metastasis of small-cell lung cancer (SCLC). The study is in mice, but points to a potential target that could be exploited to control or prevent metastatic disease. (Source: Cancer Network)
Source: Cancer Network - September 17, 2013 Category: Cancer & Oncology Source Type: news

Pomalidomide With Low-Dose Dexamethasone New Treatment Option for Multiple Myeloma
Pomalidomide, an immunomodulatory drug, combined with low-dose dexamethasone improved progression-free survival in patients with refractory or relapsed and refractory multiple myeloma compared with standard of care high-dose dexamethasone, according to a new study. (Source: Cancer Network)
Source: Cancer Network - September 17, 2013 Category: Cancer & Oncology Source Type: news

Tivozanib Fails to Show Overall Survival Difference in Metastatic RCC
The results of the study comparing Aveo’s tivozanib to sorafenib for the treatment of metastatic renal cell carcinoma showed no improvement in overall survival, the basis for the FDA’s rejection of the company’s new drug application earlier this year. (Source: Cancer Network)
Source: Cancer Network - September 16, 2013 Category: Cancer & Oncology Source Type: news

Triple-Negative Breast Cancer Tumor Stroma Plays Big Role in Bone Metastases
In order for malignancies to establish in metastatic sites, cancer cells must acquire attributes of those sites; specifically how this occurs in many cancers is relatively unknown, but a new study implicates the stroma of certain breast cancer tumors in the development of bone metastases. (Source: Cancer Network)
Source: Cancer Network - September 16, 2013 Category: Cancer & Oncology Source Type: news

Trial Suggests Imatinib Discontinuation Safe, Some Responses Persist
Evidence continues to mount that discontinuing imatinib treatment for chronic myeloid leukemia (CML) in the chronic phase is safe. A new phase II Dutch and Belgian study showed only about two-thirds of patients relapsed after discontinuing treatment with imatinib and cytarabine, and all patients remained sensitive to imatinib after relapse. (Source: Cancer Network)
Source: Cancer Network - September 16, 2013 Category: Cancer & Oncology Source Type: news

Peripheral T-Cell Lymphoma: Time for a T-Cell–Centric Standard of Care
This is an exciting time in the treatment of PTCL, but with this opportunity comes responsibility. The challenge of how to optimize a plethora of promising new therapies for a small number of patients will drive therapeutic decision making for the foreseeable future. (Source: Cancer Network)
Source: Cancer Network - September 15, 2013 Category: Cancer & Oncology Source Type: news

Peripheral T-Cell Lymphoma: What’s the Role for Transplant?
The number of recently approved agents and those under investigation is promising. However, there are currently no recommendations regarding the optimal timing for use of these agents, a reflection of the lack of data in this area and the need for prospective studies. (Source: Cancer Network)
Source: Cancer Network - September 15, 2013 Category: Cancer & Oncology Source Type: news

Collision Renal Cell Papillary and Medullary Carcinoma in a 66-Year-Old Man
The patient is a 66-year-old male who presented to his primary care physician with a 3-week history of painless gross hematuria. He underwent a renal ultrasound that showed a left kidney mass. (Source: Cancer Network)
Source: Cancer Network - September 15, 2013 Category: Cancer & Oncology Source Type: news

Clinical Applications of The Cancer Genome Atlas Project (TCGA) for Squamous Cell Lung Carcinoma
We summarize here key findings from the comprehensive analysis of squamous cell lung cancer by The Cancer Genome Atlas group and discuss the clinical implications of these findings. (Source: Cancer Network)
Source: Cancer Network - September 15, 2013 Category: Cancer & Oncology Source Type: news