Novartis kidney cancer drug clears key hurdle

Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy  Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus  Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR  Results of RECORD-1 trial address unmet medical need in renal cell cancer with worldwide regulatory filings planned for second half of 2008  Complete results to be submitted as late-breaking abstract for presentation at the American Society of Clinical Oncology meeting  Basel, February 28, 2008 — An independent data monitoring committee stopped a major Phase III clinical trial of the investigational drug everolimus (RAD001) today after interim results showed significantly better progression-free survival in patients with advanced kidney cancer who received everolimus compared to placebo. The committee stopped the trial of more than 400 patients conducted in 12 countries because the study met its primary endpoint. The interim findings are being shared with investigators to allow them to offer everolimus to patients remaining on placebo.  Everolimus may fulfill an unmet medical need for patients with advanced renal cell cancer (RCC) who currently have no approved treatment options.   E...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

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(American Association for Cancer Research) A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Wiley) A new study reveals that many people with cancer use marijuana, and rates of use in the US have increased over time. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study also found that patients with cancer are more likely to use prescription opioids than adults without cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Contributors : Yu-Chan Chang ; Michael HsiaoSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe demonstrate that RAB3C up-regulation significantly promoted cell migration and invasion in lower invasive colon cancer cell lines in vitro, as well as in distal metastases in vivoWe used microarrays to analyze the RAB3C regulated gene expression underlying invasion-metastasis cascade.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Publication date: Available online 21 April 2019Source: Journal of Molecular StructureAuthor(s): Rafael G. Silveira, Beatriz N. Cunha, Juan C. Tenório, Deborah Victória Alves de Aguiar, Patricia da Cruz Souza, Boniek Gontijo Vaz, Javier Ellena, Alzir A. Batista, Felipe Terra MartinsAbstractAbiraterone acetate is a first choice prodrug to treat prostate cancer. New higher-solubility multicomponent crystal forms of the active compound abiraterone could substitute for the commonly used acetate prodrug. Here we prepare abiraterone hydrochloride monohydrate, which is the first multicomponent crystal form of this s...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, we screened a siRNA library targeting 6024 human genes and identified Ku80 as a potential therapeutic target in melanoma cells. Knockdown of Ku80 significantly suppressed melanoma cell proliferation and induced apoptosis, as well as enhanced the antitumor effect of melatonin in melanoma in vitro and in vivo. Overexpression of Ku80, however, promoted melanoma growth and increased the insensitivity of melanoma cells to melatonin. Mechanistically, we found that Ku80 bound to the PDK1 promoter and activated the transcription of PDK1. Moreover, we showed that the binding of Ku80 at the PDK-1 promoter was HIF1-&al...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: 1 August 2019Source: Carbohydrate Polymers, Volume 217Author(s): Yalda Rahbar Saadat, Ahmad Yari Khosroushahi, Bahram Pourghassem GargariAbstractSeveral scientific evidences have revealed probiotics implications on human health. A wide range of lactic acid bacteria (LAB) have been extensively studied for their ability to produce extracellular polysaccharides (EPSs), which are repeating units of mono/oligosaccharides with various chemical compositions and properties. Despite the conventional belief regarding probiotics that states bacteria must be alive to exert their beneficial effects, mounting evidence ...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 20 April 2019Source: Inorganica Chimica ActaAuthor(s): Dhrubajyoti Majumdar, Sourav Das, Renjith Thomas, Zakir Ullah, S.S. Sreejith, Dhiraj Das, Pooja Shukla, Kalipada Bankura, Dipankar MishraAbstractTwo new dicyanamide modulated zinc metal complexes [Zn4(LOMe)2(µ1-dca)2(µ1,5-dca)2] (1) and [Zn3(LOEt)2(H2O)(µ1-dca)(µ1,5-dca)](2) have been synthesized using H2vanen-type compartmental ligands. Schiff base ligands and the complexes were characterized by means of elemental analyses, FT-IR, FT-Raman, UV-Visible, powder X-ray diffraction, TGA and fluorescence spectroscop...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 20 April 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): B.E. Amantea, R.D. Piazza, J.R.V Chacon, C.C. Santos, T.P. Costa, C.O. Rocha, J.V. Brandt, D.R.M. Godoi, M. Jafelicci, R.F.C. MarquesAbstractThe ability to generate heat from magnetic nanoparticle and the response of thermosensitive polymers poly(n-isopropylacrylamide) (PNIPAm) and poly(n-vinyl caprolactam) (PNVCL) are properties that have promoted several studies in controlled drug release systems. As the lower critical solution temperatures (LCST) of PNIPAm and PNVCL are between 32-35 ...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
AbstractIntroductionBased on the observation of beneficial effects on cancer metabolism, microenvironment, or VEGF-signaling, several non-anticancer drugs have been discussed as useful in renal cell carcinoma (RCC). In the present study, we investigated the prognostic impact of concomitant medication in RCC and correlated comedication with cell-cycle and proliferation activity in corresponding surgical specimen.MethodsA total of 388 patients who underwent surgery for localized RCC were included. The individual medication was evaluated according to substance classes. Tissue microarrays from corresponding tumor specimen were...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
n the original publication, in a title of Table  2
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
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