Novartis kidney cancer drug clears key hurdle
Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR Results of RECORD-1 trial address unmet medical need in renal cell cancer with worldwide regulatory filings planned for second half of 2008 Complete results to be submitted as late-breaking abstract for presentation at the American Society of Clinical Oncology meeting Basel, February 28, 2008 — An independent data monitoring committee stopped a major Phase III clinical trial of the investigational drug everolimus (RAD001) today after interim results showed significantly better progression-free survival in patients with advanced kidney cancer who received everolimus compared to placebo. The committee stopped the trial of more than 400 patients conducted in 12 countries because the study met its primary endpoint. The interim findings are being shared with investigators to allow them to offer everolimus to patients remaining on placebo. Everolimus may fulfill an unmet medical need for patients with advanced renal cell cancer (RCC) who currently have no approved treatment options. E...
Authors: Arnouil N, Gelet A, Matillon X, Rouviere O, Colombel M, Ruffion A, Mège-Lechevallier F, Subtil F, Badet L, Crouzet S Abstract OBJECTIVE: To analyse the functional and oncologic outcomes at one year of focal therapy with HIFU compared with total prostatectomy in patients with localised prostate cancer (PCa). PATIENTS AND METHODS: Retrospective and monocentric study from 2008 to 2014 comparing 2 cohorts of patients with localised PCa (T1/T2 clinical stage, Gleason score≤3+4=7 and PSA
In a heartwarming reunion, a 9-year-old celebrating his cancer remission has met the man who saved him.
This study aims to check the feasibility of the KDPI for a Spanish population and its predictive ability of graft and patient survival. MATERIALS AND METHODS: Data from 2,734 kidney transplants carried out in Andalusia between January 2006 and December 2015 were studied. Cases were grouped by recipient age, categorised by KDPI quartile and both graft and patient survival were compared among groups. RESULTS: The KDPI accurately discriminated optimal organs from suboptimal or marginal ones. For adult recipients (aged: 18-59years) it presents a hazard ratio of 1.013 (P
About one in five older patients with advanced cancer report financial difficulties, which in turn, take a toll on their mental well-beingMedscape Medical News
The Bentley family has suffered more than most from cancer due to faulty gene. So, to combat this, Ian, 53, and Sarah, 29, from Cheshire, took drastic action.
A two-prong approach was able to reduce opioid use by 46% in post-op surgical patients without increasing pain or anxiety.Medscape Medical News
Radiation dermatitis occurs when radiotherapy, a standard cancer treatment, damages the healthy skin cells. People can ease skin redness and peeling with calming skincare routines, some of which we explain here.
The study found that only 16 percent of the patients had another reaction after receiving an additional vaccination. The researchers also found that more than 80 percent of these subsequent reactions were not any more severe than the initial reaction.
More than 11,800 men a year are now killed by the disease in Britain, compared with about 11,400 women dying of breast cancer. The European Association of Urology led the new poll.
BOSTON (CBS) – The Massachusetts Department of Public Health is reporting an increase in hepatitis A cases in the state. The department says there have been 65 total cases reported statewide since April, including 30 in Boston. The infected patients had been experiencing homelessness or substance use disorder, according to the department. One infected person has died. We are working with local health departments and providers to increase services and vaccination for an outbreak of #hepatitis A infection in people experiencing #homelessness and/or #substanceuse disorder. Read the press release: https://t.co/TcVMC96V...
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