Novartis kidney cancer drug clears key hurdle

Everolimus (RAD001) significantly extends progression-free survival in advanced kidney cancer patients after failure of other targeted therapy  Outstanding interim results cause independent data monitoring committee to immediately share findings; patients on placebo to be offered everolimus  Everolimus (RAD001) tablet, taken once daily, demonstrated highly effective anti-tumor activity through continuous targeted inhibition of mTOR  Results of RECORD-1 trial address unmet medical need in renal cell cancer with worldwide regulatory filings planned for second half of 2008  Complete results to be submitted as late-breaking abstract for presentation at the American Society of Clinical Oncology meeting  Basel, February 28, 2008 — An independent data monitoring committee stopped a major Phase III clinical trial of the investigational drug everolimus (RAD001) today after interim results showed significantly better progression-free survival in patients with advanced kidney cancer who received everolimus compared to placebo. The committee stopped the trial of more than 400 patients conducted in 12 countries because the study met its primary endpoint. The interim findings are being shared with investigators to allow them to offer everolimus to patients remaining on placebo.  Everolimus may fulfill an unmet medical need for patients with advanced renal cell cancer (RCC) who currently have no approved treatment options.   E...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

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Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
Authors: Jing LW, Zhang C, Jin F, Wang AP Abstract BACKGROUND There is a great need for a quality of sexual life questionnaire (QVS) in breast cancer survivors (BCSs) based on the Chinese social culture since the imported tools lack localization verification. To develop a QVS in BCSs and determine its validity and reliability. MATERIAL AND METHODS In the qualitative study, a total of 21 BCSs were interviewed by purposive sampling and snowball sampling; and in the quantitative study, a total of 249 BCSs, who were admitted and received outpatient follow-up, were investigated. Regarding construct validity, factor anal...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS All these findings demonstrate that Bevacizumab treatment ameliorated cartilage degradation in rats subjected to chronic sports arthritic injury. Our results provide evidence supporting use of targeted therapy for VEGF in the clinical treatment of chronic sports arthritic injury. PMID: 29904041 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Turhan E, Yasli G Abstract OBJECTIVE: The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS: Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calculated using the Gail Risk Assessment Tool. Perceived and calculated risk levels were compared. Descriptive statistics and Chi-Square analysis, t-test, Multivariate Linear Regression Analysis, the Logistic Regression Analysis were conducted. RESULTS: A mean of...
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
CONCLUSIONS AND RELEVANCE: Red eyes, conjunctivitis, and anterior uveitis occur frequently in patients with Chikungunya fever. Systemic diseases, such as diabetes, hypertension, and cancer, may increase the risk of such ocular manifestations. Routine ophthalmic evaluation is warranted in patients with these medical conditions. The relevance of this study lies in the fact that this disease remains an important public health issue, since such ocular sequelae as may be present can range from mild to severe, either as an acute or a delayed manifestation. PMID: 29905918 [PubMed - in process]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, P-DLBCL should be considered among the many differential diagnoses of diffuse GGO. PMID: 29905415 [PubMed]
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
PROSTATE cancer happens when problems in an area of the male reproductive system cause cells to start dividing uncontrollably. You ’re more at risk of prostate cancer if you’re older, overweight or have a family history of the cancer. However, eating this red food can help you prevent the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: It is possible to find changes at the level of retinal pigment epithelium, as well as vascular tortuosity, retinopathy associated with cancer, and choroidal and/or retina metastases. PMID: 29907347 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
(Natural News) Much of the “positive” research out there suggesting that all vaccines are completely safe and effective is inherently flawed, unreliable, or flat-out falsified, an investigative report conducted by Slate has revealed. But many mainstream news outlets like Salon, The Huffington Post, and The Daily Beast, even Slate itself, are notorious for covering up...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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