Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex
AbstractGABAergic interneurons play a critical role in maintaining neural circuit balance, excitation –inhibition regulation, and cognitive function modulation. In tuberous sclerosis complex (TSC), GABAergic neuron dysfunction contributes to disrupted network activity and associated neurological symptoms, assumingly in a cell type-specific manner. This GABAergic centric study focuses on identifyin g specific interneuron subpopulations within TSC, emphasizing the unique characteristics of medial ganglionic eminence (MGE)- and caudal ganglionic eminence (CGE)-derived interneurons. Using single-nuclei RNA sequencing in TSC ...
Source: Acta Neuropathologica - May 7, 2024 Category: Neurology Source Type: research
Germline findings in cancer predisposing genes from a small cohort of chordoma patients
CONCLUSION: We report here a chordoma cohort of 24 families with newly found germline genetic mutations in cancer predisposing genes. We discuss implications for genetic counseling, clinical management, and universal germline genetic testing for cancer patients with solid tumors.PMID:38700789 | DOI:10.1007/s00432-024-05706-5 (Source: Clin Med Res)
Source: Clin Med Res - May 3, 2024 Category: Research Authors: Margarita Raygada Liny John Anne Liu Julianne Schultz B J Thomas Donna Bernstein Markku Miettinen Mark Raffeld Liqiang Xi Manoj Tyagi Kenneth Aldape John Glod Karlyne M Reilly Brigitte C Widemann Mary Frances Wedekind Source Type: research
Germline findings in cancer predisposing genes from a small cohort of chordoma patients
CONCLUSION: We report here a chordoma cohort of 24 families with newly found germline genetic mutations in cancer predisposing genes. We discuss implications for genetic counseling, clinical management, and universal germline genetic testing for cancer patients with solid tumors.PMID:38700789 | DOI:10.1007/s00432-024-05706-5 (Source: Clin Med Res)
Source: Clin Med Res - May 3, 2024 Category: Research Authors: Margarita Raygada Liny John Anne Liu Julianne Schultz B J Thomas Donna Bernstein Markku Miettinen Mark Raffeld Liqiang Xi Manoj Tyagi Kenneth Aldape John Glod Karlyne M Reilly Brigitte C Widemann Mary Frances Wedekind Source Type: research
Germline findings in cancer predisposing genes from a small cohort of chordoma patients
ConclusionWe report here a chordoma cohort of 24 families with newly found germline genetic mutations in cancer predisposing genes. We discuss implications for genetic counseling, clinical management, and universal germline genetic testing for cancer patients with solid tumors. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 3, 2024 Category: Cancer & Oncology Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
