Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Molecular Mechanisms and Roles of MiR-136-5p in Human Cancer and Other Disorders
CONCLUSION: The current review aims to elucidate the role of miR-136-5p in both cancer progression and non-cancerous disorders, emphasizing dysregulated signaling pathways. It also sheds light on the potential of this miRNA as a prognostic biomarker in cancer, offering valuable insights and directions for future research.PMID:38685774 | DOI:10.2174/0109298673283936240215110627 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - April 30, 2024 Category: Chemistry Authors: Xiaoling Chen Ting Lu Ying Zheng Zhiyong Lin Chaoqi Liu Ding Yuan Chengfu Yuan Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Corrigendum to "A large deletion in TSC2 causes tuberous sclerosis complex by dysregulating PI3K_AKT_mTOR signaling pathway" [GENE909 (2024) 148312/D-23-04187]
Gene. 2024 Apr 28;919:148481. doi: 10.1016/j.gene.2024.148481. Online ahead of print.NO ABSTRACTPMID:38685184 | DOI:10.1016/j.gene.2024.148481 (Source: Gene)
Source: Gene - April 30, 2024 Category: Genetics & Stem Cells Authors: Jiahui Fu Peili Liang Yingchun Zheng Cailing Xu Fu Xiong Fang Yang Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: American Journal of Physiology. Cell Physiology - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Acute effects of a ketone monoester, whey protein, or their co-ingestion on mTOR trafficking and protein-protein co-localization in human skeletal muscle
Am J Physiol Cell Physiol. 2024 Apr 29. doi: 10.1152/ajpcell.00207.2024. Online ahead of print.ABSTRACTWe recently demonstrated that acute oral ketone monoester intake induces a stimulation of postprandial myofibrillar protein synthesis rates comparable to that elicited following the ingestion of 10 g whey protein or their co-ingestion. The present investigation aimed to determine the acute effects of ingesting a ketone monoester, whey protein, or their co-ingestion on mTOR-related protein-protein co-localization and intracellular trafficking in human skeletal muscle. In a randomized, double-blind, parallel group design, 3...
Source: Am J Physiol Cell Ph... - April 29, 2024 Category: Cytology Authors: Sarkis J Hannaian Jamie Lov Zacharie Cheng-Boivin Sidney Abou Sawan Nathan Hodson Benoit J Gentil Jos é A Morais Tyler A Churchward-Venne Source Type: research
Defining the in vivo role of mTORC1 in thyrocytes by studying the TSC2 conditional knockout mouse model
CONCLUSIONS: Our thyrocyte-specific mouse model reveals that mTORC1 activation inhibits TH biosynthesis, suppresses thyrocyte gene expression, and promotes growth and proliferation.PMID:38661550 | DOI:10.1089/thy.2024.0053 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 25, 2024 Category: Endocrinology Authors: Camila Ludke Rossetti Bruna Lourenconi Alves Flavia Leticia Martins Pecanha Aime Franco Vania Nos é Everardo Magalh ães Carneiro John I Lew Ernesto Bernal-Mizrachi Joao Pedro Werneck de Castro Source Type: research
Molecules, Vol. 29, Pages 1981: CBD in the Treatment of Epilepsy
wczyk
It has been several years since highly purified cannabidiol (CBD) was registered as a medication that can be used in children of at least 2 years of age to treat different types of seizures related to Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and more recently tuberous sclerosis complex (TSC). During this time, 39 randomized clinical trials (RCTs) and 13 meta-analyses on the efficacy and safety of CBD treatment have been published. Each of the meta-analyses had its own criteria for the RCTs' inclusion and, therefore, slightly different interpretations of the analyzed data. Each of th...
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Kinga Borowicz-Reutt Julia Czernia Marlena Krawczyk Tags: Review Source Type: research
