Metabolic support by macrophages sustains colonic epithelial homeostasis
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. doi: 10.1016/j.cmet.2023.09.010. Online ahead of print.ABSTRACTThe intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial crypt cells in mice, where they metabolically supported epithelial cell proliferation in an mTORC1-dependent manner. Specifically, deletion of tuberous sclerosis complex 2 (Tsc2) in macrophages activated mTORC1 signaling tha...
Source: Cell Metabolism - October 7, 2023 Category: Cytology Authors: Stephanie Deborah Fritsch Nyamdelger Sukhbaatar Karine Gonzales Alishan Sahu Loan Tran Andrea Vogel Mario Mazic Jayne Louise Wilson Stephan Forisch Hannah Mayr Raimund Oberle Jakob Weiszmann Martin Brenner Roeland Vanhoutte Melanie Hofmann Sini Pirnes-Kar Source Type: research
Metabolic support by macrophages sustains colonic epithelial homeostasis
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. doi: 10.1016/j.cmet.2023.09.010. Online ahead of print.ABSTRACTThe intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial crypt cells in mice, where they metabolically supported epithelial cell proliferation in an mTORC1-dependent manner. Specifically, deletion of tuberous sclerosis complex 2 (Tsc2) in macrophages activated mTORC1 signaling tha...
Source: Cell Metabolism - October 7, 2023 Category: Cytology Authors: Stephanie Deborah Fritsch Nyamdelger Sukhbaatar Karine Gonzales Alishan Sahu Loan Tran Andrea Vogel Mario Mazic Jayne Louise Wilson Stephan Forisch Hannah Mayr Raimund Oberle Jakob Weiszmann Martin Brenner Roeland Vanhoutte Melanie Hofmann Sini Pirnes-Kar Source Type: research
Metabolic support by macrophages sustains colonic epithelial homeostasis
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. doi: 10.1016/j.cmet.2023.09.010. Online ahead of print.ABSTRACTThe intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial crypt cells in mice, where they metabolically supported epithelial cell proliferation in an mTORC1-dependent manner. Specifically, deletion of tuberous sclerosis complex 2 (Tsc2) in macrophages activated mTORC1 signaling tha...
Source: Cell Metabolism - October 7, 2023 Category: Cytology Authors: Stephanie Deborah Fritsch Nyamdelger Sukhbaatar Karine Gonzales Alishan Sahu Loan Tran Andrea Vogel Mario Mazic Jayne Louise Wilson Stephan Forisch Hannah Mayr Raimund Oberle Jakob Weiszmann Martin Brenner Roeland Vanhoutte Melanie Hofmann Sini Pirnes-Kar Source Type: research
Metabolic support by macrophages sustains colonic epithelial homeostasis
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. doi: 10.1016/j.cmet.2023.09.010. Online ahead of print.ABSTRACTThe intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial crypt cells in mice, where they metabolically supported epithelial cell proliferation in an mTORC1-dependent manner. Specifically, deletion of tuberous sclerosis complex 2 (Tsc2) in macrophages activated mTORC1 signaling tha...
Source: Cell Metabolism - October 7, 2023 Category: Cytology Authors: Stephanie Deborah Fritsch Nyamdelger Sukhbaatar Karine Gonzales Alishan Sahu Loan Tran Andrea Vogel Mario Mazic Jayne Louise Wilson Stephan Forisch Hannah Mayr Raimund Oberle Jakob Weiszmann Martin Brenner Roeland Vanhoutte Melanie Hofmann Sini Pirnes-Kar Source Type: research
Metabolic support by macrophages sustains colonic epithelial homeostasis
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. doi: 10.1016/j.cmet.2023.09.010. Online ahead of print.ABSTRACTThe intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial crypt cells in mice, where they metabolically supported epithelial cell proliferation in an mTORC1-dependent manner. Specifically, deletion of tuberous sclerosis complex 2 (Tsc2) in macrophages activated mTORC1 signaling tha...
Source: Cell Metabolism - October 7, 2023 Category: Cytology Authors: Stephanie Deborah Fritsch Nyamdelger Sukhbaatar Karine Gonzales Alishan Sahu Loan Tran Andrea Vogel Mario Mazic Jayne Louise Wilson Stephan Forisch Hannah Mayr Raimund Oberle Jakob Weiszmann Martin Brenner Roeland Vanhoutte Melanie Hofmann Sini Pirnes-Kar Source Type: research
