Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
Early development of the Tsc1 Purkinje cell specific mouse knockouts
Acta Neurobiol Exp (Wars). 2023 Dec 12;83(4):404-413. doi: 10.55782/ane-2023-2472.ABSTRACTTsc1 is a gene which expression results in hamartin, a protein involved in regulation of the mTOR1 pathway. Inactivation of Tsc1 gives rise to hyperactivation of the mTOR1 machinery, increased proliferation and growth of cells with subsequent cell degeneration and cell death. In humans, mutations of Tsc1 result in an inherited disorder ‑ tuberous sclerosis complex (TSC) with the concomitant multiorgan non‑malignant tumors (tubers), epileptic seizures and autistic‑like manifestations. General mouse knock‑outs, homozygous for th...
Source: Acta Neurobiologiae Experimentalis - January 15, 2024 Category: Neurology Authors: Anna S ługocka Marta Anna Przyby ła Jaros ław Jerzy Barski Source Type: research
