Metabolic support by macrophages sustains colonic epithelial homeostasis
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. doi: 10.1016/j.cmet.2023.09.010. Online ahead of print.ABSTRACTThe intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial crypt cells in mice, where they metabolically supported epithelial cell proliferation in an mTORC1-dependent manner. Specifically, deletion of tuberous sclerosis complex 2 (Tsc2) in macrophages activated mTORC1 signaling tha...
Source: Cell Metabolism - October 7, 2023 Category: Cytology Authors: Stephanie Deborah Fritsch Nyamdelger Sukhbaatar Karine Gonzales Alishan Sahu Loan Tran Andrea Vogel Mario Mazic Jayne Louise Wilson Stephan Forisch Hannah Mayr Raimund Oberle Jakob Weiszmann Martin Brenner Roeland Vanhoutte Melanie Hofmann Sini Pirnes-Kar Source Type: research
Metabolic support by macrophages sustains colonic epithelial homeostasis
Cell Metab. 2023 Sep 29:S1550-4131(23)00341-8. doi: 10.1016/j.cmet.2023.09.010. Online ahead of print.ABSTRACTThe intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic macrophages were located directly adjacent to epithelial crypt cells in mice, where they metabolically supported epithelial cell proliferation in an mTORC1-dependent manner. Specifically, deletion of tuberous sclerosis complex 2 (Tsc2) in macrophages activated mTORC1 signaling tha...
Source: Cell Metabolism - October 7, 2023 Category: Cytology Authors: Stephanie Deborah Fritsch Nyamdelger Sukhbaatar Karine Gonzales Alishan Sahu Loan Tran Andrea Vogel Mario Mazic Jayne Louise Wilson Stephan Forisch Hannah Mayr Raimund Oberle Jakob Weiszmann Martin Brenner Roeland Vanhoutte Melanie Hofmann Sini Pirnes-Kar Source Type: research
Adverse Events of Everolimus in Patients with Tuberous Sclerosis Complex Treated for Renal Angiomyolipoma/Subependymal Giant Cell Astrocytoma
Conclusion: Patients with TSC who are everolimus users had a higher tendency to develop gingivostomatitis and proteinuria compared to nonusers. However, no differences were observed in the occurrence of other adverse events between everolimus users and nonusers.PMID:37786437 | PMC:PMC10542024 | DOI:10.7150/ijms.88022 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - October 3, 2023 Category: Biomedical Science Authors: Shuo-Yan Gau Sung-Lang Chen Cheng-Siu Chang Teng-Fu Tsao Jeng-Dau Tsai Source Type: research
GSE239412 Translatome analysis of Tuberous Sclerosis Complex 1 patient-derived isogenic neural progenitor cells reveal rapamycin-dependent and independent alterations
Contributors : Inci S Aksoylu ; Pauline Martin ; Francis Robert ; Krzysztof J Szkop ; Nicholas E Redmond ; Shan Chen ; Roberta L Beauchamp ; Irene Nobeli ; Jerry Pelletier ; Ola Larsson ; Vijaya RameshSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTuberous sclerosis complex (TSC) is an inherited multi-system disorder caused by mutations in the TSC1 or TSC2 gene. TSC patients are often diagnosed with a range of neurodevelopmental (ND) manifestations termed TSC-associated neuropsychiatric disorders (TAND) including autism spectrum disorder (ASD), intellectual disability (ID), an...
Source: GEO: Gene Expression Omnibus - October 2, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study
CONCLUSIONS: Sirolimus could promote the disappearance of TSC-related RAML. The disappearance rate was correlated with the maximum diameter at baseline, and the smaller the tumor was, the higher the disappearance rate. It is well tolerated in the treatment of RAML associated with TSC.PMID:37773307 | DOI:10.1007/s12519-023-00751-5 (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - September 29, 2023 Category: Pediatrics Authors: Shuo Dun Yang-Yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-Yan Yang Qi Zhang Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Source Type: research
