Cutaneous neoplasms of uncertain differentiation
Tumours of uncertain differentiation represent a markedly heterogeneous group of neoplasms that show no identifiable line of differentiation by currently available technologies, and do not resemble any specific normal cells or tissues. Continuing advances in molecular genetics have significantly aided to our understanding of these tumours, enabling refinements in classification and better insights into their biology, and furthering the development of ancillary immunohistochemical and molecular diagnostic tests and targeted therapies in the clinical setting. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 29, 2021 Category: Pathology Authors: Ceri Morgan, Magnus Hallin, Cyril Fisher, Khin Thway Tags: Mini-Symposium: Cutaneous soft tissue tumours Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 28, 2021 Category: Pathology Source Type: research
Vulval carcinomas: an update
This article discusses the new classification and the use of p16 and p53 in the distinction. Other recent development s, including FIGO 2021 staging of vulvar cancers, is discussed here. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 28, 2021 Category: Pathology Authors: William Boyle, Raji Ganesan Tags: Mini-symposium: Update on pathology of female genital tract tumours Source Type: research
Editorial
I am pleased to serve as the guest editor for this issue of Diagnostic Histopathology, focusing on updates and their practical application in diagnosis of tumours of the female genital tract. This issue is badged with the British Association of Gynaecological Pathologists (BAGP). The BAGP is very active in education and information dissemination in gynaecological pathology. During the pandemic, the association has effortlessly adopted the virtual platform and extended to reach a worldwide audience. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 23, 2021 Category: Pathology Authors: Raji Ganesan Tags: Editorial Source Type: research
An update in pathologic diagnosis of uterine mesenchymal tumours
Recent discovery of new disease-defining molecular alterations and development of novel targeted therapies has dramatically changed the classification and management of uterine mesenchymal neoplasms. This review discusses diagnostic updates in endometrial stromal sarcoma, PEComa, uterine tumor resembling ovarian sex cord tumor (UTROSCT), inflammatory myofibroblastic tumor, NTRK fusion uterine sarcoma, COL1A1-PDGFB fusion sarcoma, and SMARC-deficient uterine sarcoma. Key clinical, morphologic, immunophenotypic, and molecular features are reviewed, with emphasis on common differential diagnoses and pitfalls, and their impact...
Source: Diagnostic Histopathology - October 22, 2021 Category: Pathology Authors: David B. Chapel, Marisa R. Nucci Tags: Mini-symposium: Update on pathology of female genital tract tumours Source Type: research
An unusual tumour metastasis in the left supraclavicular neck
We report a case of a late metastasis of adult granulosa tumour that presented as supraclavicular mass. We review the literature on metastatic adult granulosa cell tumour to this site. We discuss the molecular features that help differentiate adult granulosa cell tumour from other lesions. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 20, 2021 Category: Pathology Authors: Badia Hisham Ahmed, Olivia McKinney, Gautam Mehra Tags: Short case Source Type: research
Endometrial carcinoma: changes to classification (WHO 2020)
Since the 2014 WHO classification of Female Genital Tract tumour, there have been significant improvements in our understanding of the genomic basis of endometrial carcinoma, largely based on the seminal findings from The Cancer Genome Atlas analysis, which have been befittingly included in the newest edition for the subcategorization of endometrioid carcinomas. Nevertheless, morphological classification, with or without the aid of immunohistochemistry, remains paramount to diagnosis and correct patient management, in addition to retaining the global outreach of the 5th Classification in the absence of universal access to ...
Source: Diagnostic Histopathology - October 4, 2021 Category: Pathology Authors: Mariam Masood, Naveena Singh Tags: Mini-symposium: Update on pathology of female genital tract tumours Source Type: research
Diagnosis of pancreatic tail splenunculus on biopsy: an elusive entity
We report a case of a tail of pancreas splenunculus and review the histological characteristics pertinent to making this diagnosis. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 30, 2021 Category: Pathology Authors: Juliet Raine, Bhupinder Sharma, Andrew C Wotherspoon Tags: Short case Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 29, 2021 Category: Pathology Source Type: research
Cervical cancer: what's new in classification, morphology, molecular findings and prognosis of glandular precursor and invasive lesions
The recently published 5th edition of the WHO Classification of Female Genital Tumours has incorporated the new International Endocervical Adenocarcinoma Criteria and Classification (IECC) system for endocervical adenocarcinomas, based on morphological features linked to aetiology (Human Papillomavirus -HPV infection) as well as the Silva pattern-based classification. It is considered as a reliable system to predict patients at risk of lymph node metastases, recurrences and death from disease. Both classification systems, help to individualize clinical management and are presented in detail in this review along with most r...
Source: Diagnostic Histopathology - September 24, 2021 Category: Pathology Authors: Simona Stolnicu Tags: Mini-symposium: Update on pathology of female genital tract tumours Source Type: research
Ovarian borderline tumours and carcinomas: an update
In the 5th edition of the World Health Organization (WHO) Classification of Female Genital Tumours, published in 2020, the emphasis on accurate diagnosis of ovarian borderline tumours and carcinomas based on cell type (histotype) continues. The different histotypes of ovarian epithelial tumours are not just morphological variants of the same disease but are different diseases, associated with critically important differences in precursor lesions, risk factors, patterns of spread, molecular pathology and response to treatment. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 24, 2021 Category: Pathology Authors: C Blake Gilks Tags: Mini-symposium: Update on pathology of female genital tract tumours Source Type: research
Cervical cancer: what's new in squamous cell neoplasia
Up to 90% of cervical cancers are squamous cell carcinomas. These are divided in the WHO 5th Edition (2020) classification into HPV associated (HPVA) and HPV independent (HPVI) categories. Immunohistochemistry for p16INK4A is a reliable surrogate for the presence of high risk transforming HPV infection and the distinction should be made where resources permit. Squamous precursor lesions are classified in a single HPV associated category. Recognition of the varied histologic patterns of squamous cell carcinoma is useful in consideration of differential diagnosis. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 23, 2021 Category: Pathology Authors: Anthony Williams Tags: Mini-symposium: Update on pathology of female genital tract tumours Source Type: research
Update on cytology samples for the use of molecular pathology and other ancillary tests in the move towards next-generation sequencing
The use of molecular pathology is becoming more evident every year, with 92% of pathologists stating that they use molecular pathology on a regular basis when reporting diagnostic work. This growth has been led not just through service development and improvement, but also with the introduction of new treatments offering patients significant improvement and overall better survival from cancer. These new treatments tend to require a targeted genomic test to identify specific cohorts of patients that will benefit. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 15, 2021 Category: Pathology Authors: Robert Thomas Wilson Tags: Mini-symposium: Cytopathology Source Type: research
A summary of recent international standardised reporting systems in cytopathology
This article summarises the salient and practical points set out in some of the more recently developed international reporting systems, namely The International System for Reporting Serous Fluid Cytopathology, The Milan System for Reporting Salivary Gland Cytopathology, and The Paris System for Reporting Urinary Cytology. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 14, 2021 Category: Pathology Authors: Yurina Miki, Holly White, David Shelton, David Poller, Ashish Chandra Tags: Mini-symposium: Cytopathology Source Type: research
Cytopathology in the diagnosis, treatment and management of malignant respiratory disease
Lung carcinomas are almost always diagnosed using small samples of cellular material. Diagnostic cytopathology has a major role and, with efficient and thoughtful processing and examination of fine needle aspiration or fluid specimens, it is possible to accurately diagnose and perform a full range of predictive testing. This short piece begins by placing cytopathology within an overall umbrella of cellular pathology and briefly describes recent developments in lung cancer diagnosis and treatment. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 10, 2021 Category: Pathology Authors: Anthony Maddox Tags: Mini-symposium: Cytopathology Source Type: research
