Vulvovaginal melanocytic lesions: a review
Pigmented lesions of the vulva and vagina occur commonly and can be challenging both clinically and microscopically. Vulvovaginal melanotic macules are the most common pigmented vulvar lesion. Mucosal vitiligo can be confined to the anogenital region. Acquired melanocytic nevi of the vulva comprise approximately 10% –12% of pigmented vulvar lesions. Blue and Spitz (spindled and epithelioid cell) nevi can occur rarely in the vulvovaginal area. Although pigmented and lentiginous in histologic appearance, melanocytic lesions associated with lichen sclerosus have a “trizonal” pattern of growth, similar to rec urrent nevi...
Source: Diagnostic Histopathology - October 25, 2023 Category: Pathology Authors: Jakob MT Moran, Emily M Hartsough, Mai P Hoang Tags: Mini-symposium: skin pathology Source Type: research
Rhabdomyosarcoma and undifferentiated round cell tumours of soft tissue in children, adolescents and young adults
Soft tissue sarcomas are a rare group of heterogenous entities which affect the tissues supporting, connecting and/or surrounding body structures and organs. Factors such as patient age and tumour location can influence how soft tissue sarcomas manifest with biological and clinical behaviour ranging from less aggressive to highly malignant. Recent advances in both diagnosis and treatment have led to new insights into the pathologic, histologic and genomic characterisation of sarcomas and these insights have diversified subtyping. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 21, 2023 Category: Pathology Authors: Heather Keir, Edmund Cheesman, Michael Staunton, Gemma Petts, Anna Kelsey Tags: Mini-symposium: paediatric and perinatal pathology Source Type: research
Importance of molecular testing in stratification of paediatric low-grade gliomas: a case study
We discuss a case of a paediatric low grade glioma where the integrated diagnosis was a diffuse astrocytoma with MYB or MYBL1 alteration. Surgical excision of the tissue revealed a low grade tumour appearance with small round nuclei and fine fibrillary cytoplasm. MYB or MYBL1-alteration was shown on methylation array analysis. MYB and MYBL1 are transcriptional transactivators that have important roles in cell proliferation, and their overexpression can lead to tumour formation. The diagnosis of novel subtypes of paediatric low-grade gliomas is now possible due to the increasing role of molecular pathology. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - October 14, 2023 Category: Pathology Authors: Clare McGenity, Oleg Anichtchik, Azzam Ismail Tags: Short case Source Type: research
Chronic inflammatory conditions of the placenta
Placental inflammatory conditions comprise a main diagnostic category in placental pathology. Placental inflammation can broadly be categorised into acute and chronic, with co-existence of both in the same placenta also possible. Chronic inflammation may be of infectious or non-infectious aetiology. TORCH infections represent the majority of placental infections associated with chronic inflammation in developed countries. Non-infectious chronic placental inflammatory conditions, such as villitis of unknown aetiology (VUE) and chronic histiocytic intervillositis (CHI) are currently attributed to immune-mediated mechanisms a...
Source: Diagnostic Histopathology - October 12, 2023 Category: Pathology Authors: Mudher Al-Adnani, Andreas Marnerides Tags: Mini-symposium: paediatric and perinatal pathology Source Type: research
Renal tumours of childhood: what's new in classification, morphology, molecular findings and prognosis
Despite being one of the most frequent solid tumours in children, renal tumours are uncommon. Their accurate diagnosis and staging are essential for the appropriate treatment because they comprise a variety of entities with a broad spectrum of clinical, histological, molecular biology, and prognostic features. Wilms tumour (WT) accounts for 80 –85% of renal tumours of childhood, whereas other tumours including mesoblastic nephroma, clear cell sarcoma, rhabdoid tumour, renal cell carcinoma, and others are extremely uncommon (up to 2%–4% each), which explains why they pose a significant diagnostic challenge for patholog...
Source: Diagnostic Histopathology - October 11, 2023 Category: Pathology Authors: Gordan M Vujani ć, Laura Galluzzo Mutti, Sergey D Popov Tags: Mini-symposium: paediatric and perinatal pathology Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - September 23, 2023 Category: Pathology Source Type: research
A well-differentiated neuroendocrine tumour of high grade
Neuroendocrine neoplasms (NEN) are a group of epithelial neoplasms with neural and endocrine differentiation, one of the main sites of origin being the gastrointestinal tract and pancreas (GEP). One of the common groups of GEP-NEN, well-differentiated neuroendocrine tumour (WD-NET), is a biologically distinct group from poorly differentiated neuroendocrine carcinoma (PD-NEC). Accurate histopathological distinction of WD-NET from PD-NEC is critical for prognostication and deciding on optimal therapeutic approaches. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 10, 2023 Category: Pathology Authors: Seung Hyun Lee, Tu Vinh Luong Tags: Short case Source Type: research
A case of renal cell-like sinonasal adenocarcinoma: a rare entity
Renal cell-like sinonasal adenocarcinoma (RCLSA) is a rare entity and it is one of the variants of non-intestinal type sinonasal adenocarcinoma which arises in nasal cavity, paranasal sinuses and nasopharynx. This low-grade malignancy is characterised by neoplastic gland formation with monomorphic lesional cells displaying clear to eosinophilic cytoplasm. The histological features of RCLSA are not specific to this entity; one is required to exclude primary and metastatic tumours which have a similar morphology. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 10, 2023 Category: Pathology Authors: Anastasiya Kret, Miran Pankhania, Ali Al-Omari Tags: Short case Source Type: research
Pitfalls in thyroid pathology and the medicolegal aspects of error
This article is a brief review of diagnostic error in thyroid cytopathology and histopathology with a discussion of more general medicolegal aspects of error in histopathology and cytopathology relevant to thyroid pathology. Pre-operative ultrasound guided thyroid FNA cytology is the standard pre-operative investigation for thyroid nodules. FNA is effective in triaging thyroid nodules. The cytological features of papillary thyroid carcinoma are readily identified in FNA specimens. Needle core biopsy may also be useful in some circumstances if fine-needle aspiration is unhelpful. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - August 9, 2023 Category: Pathology Authors: David N Poller Tags: Mini-symposium: endocrine pathology Source Type: research
Brief overview of the updated third edition of the Bethesda System for Reporting Thyroid Cytopathology
The 2023, 3rd edition of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is an updated version of the widely used system for reporting thyroid fine-needle aspiration (FNA) results. The new edition reflects advances in the field of thyroid cytology since the publication of the 2nd edition. The most significant changes in the 3rd edition include: a simplified reporting structure with single names for each of the six diagnostic categories; updated and recalculated risk of malignancy for each category; harmonization of nomenclature with the 2022 World Health Organization classification of thyroid tumors; and d...
Source: Diagnostic Histopathology - August 5, 2023 Category: Pathology Authors: Paul A VanderLaan, Syed Z Ali Tags: Mini-symposium: endocrine pathology Source Type: research
Molecular alterations of follicular cell-derived thyroid neoplasms
Considerable knowledge about the molecular pathogenesis of follicular cell-derived thyroid tumors has been acquired in the last decade using next generation sequencing technique. This review summarizes the correlation among molecular profiles, histopathologic classification, and clinical behaviors of follicular cell-derived thyroid neoplasms. RAS-like molecular signatures are seen in well-differentiated follicular-patterned neoplasms and poorly differentiated thyroid carcinoma; BRAFV600E-like profile prevails papillary thyroid carcinoma (particularly classic and tall cell subtypes) and high grade differentiated thyroid car...
Source: Diagnostic Histopathology - August 3, 2023 Category: Pathology Authors: Bin Xu Tags: Mini-symposium: endocrine pathology Source Type: research
Atypical endometriosis: a review of an incompletely understood putative precursor of endometriosis-associated ovarian carcinoma
Endometriosis is a common, morbid disease affecting 10% of reproductive age women. While typically considered a benign entity, approximately 1% of endometriotic foci will give rise to malignancy. Predicting which lesions have a higher risk of progression has been an area of recent interest, with a resurgence of the term “atypical endometriosis” (AE) in the literature. AE is defined as endometriosis with architectural and/or cytologic atypia. However, the inclusion of both architectural and cytologic abnormalities has historically been controversial. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - July 28, 2023 Category: Pathology Authors: Lauren J. Ray, Jaclyn C. Watkins Tags: Mini-symposium: gynaecological pathology Source Type: research
An overview of artificial intelligence applications for next-generation gynaecological pathology
With the drive to roll out digital pathology in the UK, implementation of artificial intelligence (AI) tools for pathology is now a possibility, bringing with it the potential to change how we work as a specialty. AI promises many benefits for working practices such as improved efficiency and consistency, financial and productivity gains and ultimately a better service for our patients. Gynaecological pathology is a diverse specialty with many potential avenues for algorithm development, yet there are relatively few nearing clinical validation compared to other pathology specialties. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - July 25, 2023 Category: Pathology Authors: Sarah Bell, James D. Blackwood, Christina Fell, Mahnaz Mohammadi, David Morrison, David Harris-Birtill, Gareth Bryson Tags: Mini-symposium: gynaecological pathology Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - July 22, 2023 Category: Pathology Source Type: research
