An update on atypical large glandular proliferations of the prostate
The differential diagnosis of prostatic atypical large gland proliferations includes several benign and malignant entities. This review focusses on issues relevant to the practising pathologist, particularly around areas of controversy such as high-grade prostatic intraepithelial neoplasia (HGPIN) and intraductal carcinoma of the prostate (IDCP). HGPIN is a putative precursor of prostate cancer, but its clinical relevance is as a surrogate marker of unsampled prostate cancer, thereby identifying patients who would benefit from a prompt repeat biopsy. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 30, 2023 Category: Pathology Authors: Murali Varma Tags: Mini-symposium: Updates in genitourinary pathology Source Type: research
Updates in the pathology of penile intraepithelial neoplasia
Penile intraepithelial neoplasia (PeIN) is the putative histologic precursor of penile squamous cell carcinoma. PeIN is classified into HPV-associated and HPV-independent (differentiated) (dPeIN). While HPV-associated PeIN is has been linked to the oncogenic effect of human papillomavirus (HPV), the HPV-independent pathway is driven by chronic inflammatory conditions. These two biologic pathways are associated with distinct histopathologic features. The most common morphologic patterns of HPV-associated PeIN are basaloid, warty, and mixed PeIN. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 29, 2023 Category: Pathology Authors: Giovanna A. Giannico, Antonio L. Cubilla Tags: Mini-symposium: Updates in genitourinary pathology Source Type: research
Medical renal mentionables: minimal change disease, membranous nephropathy and monoclonality
Advances in our understanding and ability to diagnose medical renal disease occur daily. Herein is described the recent identification of anti-nephrin antibodies in a subset of patients with minimal change disease, how the application of laser microdissection and mass spectrometry has identified multiple new antigenic targets in membranous nephropathy, and how the application of a new immunofluorescence technique targeting the junction of heavy chain and light chain constant regions may assist in determining the monoclonal nature of renal disease. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 29, 2023 Category: Pathology Authors: Meghan E. Kapp Tags: Mini-symposium: updates in genitourinary pathology Source Type: research
Burkitt-like lymphoma with 11q aberration in a patient with chronic lymphocytic leukaemia: a potentially unrecognised association
We report a case of a 68-year old male with a previous history of CLL, who presented with an obstructing caecal mass. Microscopy revealed high grade features resembling Burkitt lymphoma; however, no MYC rearrangement was detected and subsequent FISH studies detected 11q aberration. Although this profile is now a recognized entity in the revised 4th edition of the WHO classification of Tumours of Haematopoietic neoplasms as “Burkitt-like lymphoma with aberration in 11q”, this has not previously been reported in patients with previous or concurrent CLL. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 20, 2023 Category: Pathology Authors: Amanda Hilton, Dilek Taze, Hebah Ali Tags: Short case Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 18, 2023 Category: Pathology Source Type: research
Malignant mesothelioma of the tunica vaginalis and epididymis
We present a case of epididymis and tunica vaginalis MM that was incidentally diagnosed on histological examination following a hydrocelectomy. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 17, 2023 Category: Pathology Authors: Thomas B. Dytor, Clare Verrill, Yalda Alizadeh Tags: Short case Source Type: research
The pathological and clinical heterogeneity of mantle cell lymphoma
Mantle cell lymphoma is a well-defined B-cell lymphoma entity with characteristic morphological, immunophenotypical and molecular findings. However, in the last decades significant heterogeneity of the disease has been identified with important consequences for the clinical management of the disease. Importantly, some mantle cell lymphomas show an indolent behaviour, which might be overtreated with traditionally used intensive chemoimmunotherapy regimens for this entity. In this article the clinical heterogeneity and current pathological concepts in mantle cell lymphoma are reviewed, with a focus on diagnostic hematopathol...
Source: Diagnostic Histopathology - March 16, 2023 Category: Pathology Authors: Marco B ühler, Elias Campo Tags: Mini-Symposium: Lymphoreticular Pathology Source Type: research
Salivary neoplasia cytopathology: a logical diagnostic approach to cytological interpretation using histopathology knowledge
Fine needle aspiration cytology (FNAc) plays a vital investigative tool in the diagnostic and management pathway of the benign and malignant salivary pathologies. The current practice guidelines dictate acquirement of the nature of the salivary gland disease prior to embarking on definitive surgery. FNAc is a rapid, relatively easy, non-invasive diagnostic tool with minimal complications that achieves this goal. The diagnostic adequacy and the accuracy of FNAc sampling depends on a variety of factors including the operator aptness, lesional characteristics and patient factors. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - March 2, 2023 Category: Pathology Authors: Gayani Pitiyage Tags: Mini-symposium: head and neck pathology Source Type: research
Oral potentially malignant disorders: a practical review for the diagnostic pathologist
This article provides a broad overview of oral potentially malignant disorders (OPMD) and associated entities. The review opens with an update on the terminology surrounding OPMD before summarizing the lesions and conditions currently recognized as OPMD by the World Health Organization (WHO). Approaches to diagnosing oral epithelial dysplasia (OED) are discussed in the context of the WHO's recently modified architectural and cytological criteria for OED. The spectrum of reactive epithelial changes – which may mimic OED - is explored for comparison. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 25, 2023 Category: Pathology Authors: Timothy John Bates, Andrea Richards, Miranda Pring Tags: Mini-symposium: head and neck pathology Source Type: research
Editorial board
(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 23, 2023 Category: Pathology Source Type: research
Current concepts in PD-L1 testing in head and neck squamous cell carcinoma: overview, developments and challenges
Cancer immunotherapy is arguably the biggest success story of personalized medicine in the past two decades. Monoclonal antibodies targeting immune checkpoint inhibitors like PD-1 have shown success in clinical trials in a variety of solid tumours. The histopathologist has a central role in determining patient eligibility for immunotherapy by virtue of the histological assessment of tumours and their characterization of the tumour immune microenvironment. There is now a plethora of companion diagnostic PD-L1 immunohistochemical assays for use across multiple tumour types and platforms. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 23, 2023 Category: Pathology Authors: Lisette HC Collins, Karwan A. Moutasim Tags: Mini-symposium: head and neck pathology Source Type: research
Diagnostic and prognostic biomarkers in salivary gland tumours
Salivary glands are a heterogeneous group of neoplasms and are diagnostically challenging with overlapping microscopic features between tumours as well as intra-tumour morphological diversity. Correct diagnosis is essential to ensure appropriate management and follow-up. Morphological and cytological analysis of haematoxylin and eosin stained tissue sections is supplemented by a large number of immunohistochemical and special stains as well as molecular rearrangements. A broad literature search was performed to provide an overview of all biomarkers used for diagnosis and prognosis prediction of salivary gland tumours. (Sou...
Source: Diagnostic Histopathology - February 16, 2023 Category: Pathology Authors: Hannah Walsh, Saleh Alghamdi, Manas Dave, Ibrahim Alsanie, Syed Ali Khurram Tags: Mini-symposium: head and neck pathology Source Type: research
A pot pourri of sinonasal stinkers: diagnostic pitfalls in nasal polyps not to be sniffed at
We often associate nasal olfaction with desirable sensations, but the nose and paranasal sinuses also have an important role in filtration, detection and inactivation of particulate, chemical and biological irritants or toxins. The delicate mucosal lining of the sinonasal tract can be damaged by these external insults, and mutations affecting its diverse cellular components can result in an abundance of histological tumour types. While these are too numerous to catalogue in this short article, we have chosen a “fragrant pot pourri” of tumour types that have caused these authors diagnostic difficulties in the past and s...
Source: Diagnostic Histopathology - February 16, 2023 Category: Pathology Authors: Hoi Ki Leung, Elinor George, Tim Bracey Tags: Mini-symposium: head and neck pathology Source Type: research
A case of sclerosing odontogenic carcinoma: a rare entity
Sclerosing odontogenic carcinoma (SOC) is a very rare entity, first recognized in the WHO 4th edition (2017). It is a highly infiltrative intraosseous jaw tumour with small nests, strands and cords of cells showing only mild cytological atypia, surrounded by a dense fibrocollagenous stroma. The lesion frequently infiltrates adjacent tissues and bony structures and demonstrates perineural and intraneural invasion. The malignant islands of cells may be compressed by the stroma, making them difficult to identify. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 16, 2023 Category: Pathology Authors: Natasha Cutmore, Preetha Chengot Tags: Short case Source Type: research
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(Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - February 1, 2023 Category: Pathology Source Type: research
