Histopathology features of the lung in COVID-19 patients
COVID-19 is the infectious disease caused by the recently discovered coronavirus, SARS-CoV-2, unknown before the outbreak in Wuhan, China, in December 2019. COVID-19 is a pandemic, infectious disease that has simultaneously affected many countries globally. The leading cause of dead in patients with COVID-19 is hypoxic respiratory failure from acute respiratory distress syndrome (ARDS). Diffuse alveolar damage (DAD) is the histopathological pattern commonly described in all the postmortem series up to date. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - December 4, 2020 Category: Pathology Authors: M. Angeles Montero-Fern ández, Ricardo Pardo-Garcia Source Type: research
Pathology of immune checkpoint inhibitor-induced injury of the gastrointestinal tract and hepatobiliary system
Immune checkpoint inhibitors (ICIs) are becoming the standard of care treatment for many malignancies. ICIs are associated with a unique spectrum of immune-related adverse events (irAEs) due to the blockade of inhibitory signals of immune activation. The main objective of this study is to review the characteristic histological features and pathologic differential diagnosis of ICI-related injury of the gastrointestinal (GI) tract and hepatobiliary system. Diarrhea and hepatitis are some of the more common irAEs. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - November 26, 2020 Category: Pathology Authors: Kshitij Arora, M. Lisa Zhang, Maria Bel én Goiburú-Chenu, Jonathan England Tags: Mini-symposium: Gastrointestinal & hepato-pancreato-biliary pathology Source Type: research
The importance of considering hepatitis E as a differential for acute hepatitis
We present the case of a patient with acute transaminitis, with positive anti-smooth muscle antibody and hepatitis E antibodies. The remainder of the non-invasive liver screen was unremarkable. A liver core revealed moderately active acute hepatitis with portal and parenchymal inflammation, including apoptotic bodies and focal confluent necrosis. The features were in keeping with an acute hepatitis, with a differential of either drug, viral or autoimmune aetiology. Hepatitis E RNA was subsequently detected by PCR. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - November 26, 2020 Category: Pathology Authors: Caroline A. Young, Alyn L. Cratchley Tags: Short Case Source Type: research
Severe cutaneous adverse drug reactions
This article focuses on three particularly dangerous forms of cutaneous adverse reactions, namely acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome and toxic epidermal necrolysis. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - November 25, 2020 Category: Pathology Authors: Katrin Kerl, Helmut Kerl Tags: Mini-symposium: Dermatopathology Source Type: research
Inflammatory and infectious skin diseases presenting as cutaneous pseudolymphoma
Cutaneous pseudolymphomas are a heterogeneous group of reactive lymphocytic infiltrates, which simulates cutaneous lymphomas clinically and histologically. Although in many cases the pathogenesis is not understood, a broad spectrum of different agents inducing pseudolymphomas has been reported. Cutaneous pseudolympomas are distinguished in four main groups: (a) nodular pseudolymphomas, (b) pseudo-mycosis fungoides (pseudo-MF) and simulators of other CTCLs, (c) other pseudolymphomas and (d) an intravascular pseudolymphoma. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - November 23, 2020 Category: Pathology Authors: Christina Mitteldorf Tags: Mini-symposium: Dermatopathology Source Type: research
