Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata
A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem ofRhamnus crenata, together with eight known compounds2 –9. The structure of new compound1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-α-L-rhamnopyranoside (5), and quercetin 7-O-α-L-rhamnopyranoside (6) showed potent inhibition with IC50 values of 33.18 ± 2.73, 35.52 ± 3.27, 28.05 ± 1.85, and 26.41 ± 3.01 μM, respectively, against LPS-induced NO generation. In addition, compounds3,5, and6 also showed potent DPPH radica...
Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research
Synthesis of 1R-cis-Dibromovinyl-2,2-dimethylcyclopropanes of the Isoxazole and Pyrazole Series Based on (+)-3-Carene
New 1,3-disubstituted 2,2-dimethylcyclopropanes of the isoxazole and pyrazole series were synthesized starting from (+)-3-carene. Olefination of the reductive ozonolysis product of (+)-4-acetyl-2-carene produced 1R-cis-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane, further reaction of which with hydroxylamine or hydrazines led to heterocyclic compounds. It was shown that 3,5-dimethylpyrazoles could be synthesized on the surface of Al2O3 using ultrasonic irradiation. Studies of the antimicrobial activity of heterocyclic derivatives of dibromovinyl-2,2-dimethylcyclopropane found significant fungicidal effects of pyrazoles8,1...
Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research
Synthesis and Anti-Vibrio Activity of Gallic Acid Derivatives Containing Acyl Thiourea Phenol
A series of gallic acid derivatives containing acyl thiourea phenol were designed and synthesized with gallic acid as a raw material, and their antibacterial activities were evaluated: the synthesized acyl thiourea phenol derivatives of gallic acid had certain anti-Vibrio activity at 1 mg/mL; compounds4a and4c showed good inhibitory activity againstVibrio harveyi, MIC was 0.0156 mg/mL; compound4f also showed certain anti-Vibrio cholerae activity, MIC was 0.0313 mg/mL; compound4g showed anti-Vibrio parahaemolyticus activity, MIC was 0.0156 mg/mL; this series of compounds has poor inhibitory activity againstVibrio vulnificus...
Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research
Lipid Contents and Mineral Elements of Some Cowpea Genotypes (Vigna unguiculata)
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research
Soyasaponin A1 Ester from Glycine max (Soybean)
The hydro-alcoholic extract ofGlycine max (soybean), upon chemical constituents investigation lead to the isolation compound (1) named as soyasaponin A1 ester apart from other known compounds soyasaponins M1, M2, M3, soyasaponin A1, A2, and robinioside. All compounds were characterized by spectroscopic techniques including 2D NMR spectroscopy. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research
Chemical Constituents of Ferula lapidosa
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research
A New Macrolide from the Strain Cordyceps spp. from Cell Fusion between Cordyceps militaris and Cordyceps cicadae
A new macrolide cephalolidedifuran A (1), together with two known cephalosporolides B (2), and I (3), was isolated from the fungusCordyceps spp., a strain from cell fusion betweenCordyceps militaris andCordyceps cicadae. Their structures were identified on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay for anti-nematode activity of all the isolates showed that compounds1 and3 revealed moderate inhibitory activity against the nematodePanagrellus redivivus, with a mortality ratio of 48.35 and 59.16% at 2.5 mg/mL, respectively. Moreover, compounds1 –3 showed weak inhibitory activity against AChE at the ...
Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research
Hepatoprotective Phenylpropanoid Glycosides from Highland Barley Monascus purpureus
A new phenylpropanoid glycoside, named 4-O-β-D-glucopyranosyl-7-phenyl-9-propenyl ketone-9-O-β-Dglucopyranosyl-(6 ′′→1′′′)-6′′-O-α-L-rhamnopyranose (1), and four known phenylpropanoid glycosides2 –5 were isolated from highland barleyMonascus purpureus Went for the first time. Their structures were determined by their comprehensive spectral data and reported references. Compounds1 –5 were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 cells with bicyclol as positive control. As a result, compounds1 and2 exhibited moderate hepatoprotective activities...
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
Isolation, Purification, and Properties of Glycoprotein from Sheep Intestinal Mucous Membrane
A glycoprotein inhibiting the growth of colon cancer cells was isolated from sheep intestinal mucous membrane. The glycoprotein, designated IGP, was purified by a combination of ion-exchange chromatography over DEAE-650M and gel-filtration over HW-55F. Purified IGP had a molecular mass of ~60 kDa and consisted of 68.72 ± 2.10% protein and 32.09 ± 1.52% carbohydrates. The monosaccharide composition of the carbohydrate part consisted of glucose (31.28% of the total carbohydrate content), glucosamine (22.28%) andN-acetylgalactosamine (19.38%), mannose (11.14%), fucose (11.28%), and rhamnose (4.64%). The amino-acid compositi...
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
A New Triterpenoid from Gymnema sylvestre and its Allelopathic Activity
A new triterpenoid (1) and four known compounds (2 –5) were isolated fromGymnema sylvestre. The structure of compound1 was elucidated as (3β,16β,22α)-22-benzoyloxy-16,23,28,29-tetrahydroxyolean-12-en-3-yl-O-β-D-glucopyranosiduronic acid by spectroscopic data (1H,13C NMR, HMBC, HSQC, COSY, and NOESY). Additionally, compound1 presented allelopathic activity on the growth of lettuce at 100 μM. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
Secondary Metabolites of Endophytic Fungi Aspergillus fumigatus from Scutellaria formosana
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
Secondary Metabolites from the Leaves and Twigs of Acer pseudosieboldianum
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
New Hybrid Cytisine Derivatives Containing a Thienopyrimidine Fragment
New cytisine-thienopyrimidine hybrid molecules were synthesized by reacting cytisine with 4-chlorothieno [2,3-d]pyrimidines in the presence of Et3N. The solvent effect on the course of the reaction was studied. The structures of the obtained compounds were elucidated using IR,1H and13C NMR spectroscopy and TLC-MS spectrometry. X-ray crystal structure analyses of the synthesized compounds were performed. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
Synthesis of Novel Stigmasterol Derivatives with 1,2,3-Triazole Substituent at the C-3 Position and Their Cytotoxicity Toward HeLa, HGC-27, and HEK-293T Cells
Eight new stigmasterol derivatives possessing 1,2,3-triazoles moiety were synthesized by a 1,3-dipolar cycloaddition reaction. All the compounds were characterized by IR, NMR, and HR-MS. In addition, human cervical cancer cells (HeLa), human gastric cancer cells (HGC-27), and human renal epithelial cells (HEK-293T) were selected to study the antitumor activity of the synthesized compounds. The results demonstrated that compounds3c and3d exhibited better inhibitory activity against the tested tumor cell lines. The IC50 value of the inhibitory activity on HeLa was 52.3 μmol·L–1 and 31.4 μmol·L–1, and 40.6 μmol·L–...
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
Secondary Metabolites from the Endophytic Fungus Xylaria sp. GDG-102 by Osmac Strategy and Their Antibacterial Activities
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 30, 2024 Category: Chemistry Source Type: research
