A New Phenylalkanoid of Alpinia galanga
A new ferulate-derived, (E)-15-{[3-(4-hydroxy-3-methoxyphenyl)acryloyl]oxy}pentadecanoic acid (named as alpinagalanate) (1), 19 known compounds were isolated from the rhizomes ofAlpinia galanga (Zingiberaceae). The structure of the new phenylalkanoid was elucidated by chemical and physical evidence. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - September 13, 2023 Category: Chemistry Source Type: research
Fatty-Acid Composition of Artemisia obtusiloba and Related Species
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - September 12, 2023 Category: Chemistry Source Type: research
Chemical Constituents and Antitumor Activities of the Edible Mushroom Cortinarius rufo-olivaceus
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - September 12, 2023 Category: Chemistry Source Type: research
Constituents of Lipid Fractions from Artemisia scoparia in Various Phenological Phases
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - September 12, 2023 Category: Chemistry Source Type: research
Aminomethylation of Quercetin by Tetrahydroisoquinoline Derivatives and Their Biological Activity
Monosubstituted quercetin conjugates were synthesized via Mannich reactions from 1-aryl-(or H)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines in 75 –96% yields. Compounds with antihypoxic activity more effective than that of quercetin were found among them. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - August 2, 2023 Category: Chemistry Source Type: research
Newly Synthesized N-Glycosidic Halochalcones Reveal Inhibitory Activity on Pancreatic Triacylglycerol Lipase
In this study, the aim was to synthesizeN-glycosidic halochalcone derivatives and to examine their lipase inhibitory activity. The synthesized chalcones (1 –3) were well known and the data were compatible with previous findings. However, compounds4a/b,5a/b,6a/b, and7 –9 were synthesized for the first time in the current study. Remarkable lipase inhibitory potentials of the synthesized compounds were further confirmed through molecular docking studies. The highest lipase inhibition activity was experimentally identified for compounds2 and5a with IC50 17.7133 ± 0.9648 μg/mL and IC50 22.6521 ± 1.2146 μg/mL, respective...
Source: Chemistry of Natural Compounds - August 1, 2023 Category: Chemistry Source Type: research
Carbamide Derivatives of Lappaconitine
Carbamide derivatives of lappaconitine were prepared via reactions ofN-deacetyllappaconitine andN-20-norlappaconitine with potassium isocyanate, phenylisocyanate, or triphosgene followed by treatment with various amines. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - August 1, 2023 Category: Chemistry Source Type: research
Biflavonoids from Selaginella trichoclada
Thirteen robustaflavones (1 –13) were isolated from the 70% EtOH extract of Selaginella trichoclada Alston herbs for the first time. The structures of these compounds were identified on the basis of extensive spectroscopic data including UV-vis, 1D and 2D NMR, and mass spectra. The molecular docking results indicate that the robustaflavone derivates may play a role as a NEDD4 protein inhibitor. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
Synthesis of New 9-Substituted Derivatives of 2-Oxomethylcytisine
New derivatives of 3-methylcytisine with 9-aromatic substituents bonded to the pyridone core of the starting alkaloid through spacers of various natures, e.g., aminomethyl, amide, thio- and carboxamide, ethenyl, and ethyl, were synthesized from 9-amino- and 9-bromo-2-oxomethylcytisine. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
Alkylation of Triacanthine by Benzyl Chloride
The reaction of the purine alkaloid triacanthine with benzyl chloride in two temperature regimes produced multicomponent mixtures consisting of benzyl derivatives of triacanthine and adenine. The structures of the synthesized products were elucidated by X-ray crystal structure analyses and NMR spectroscopy. The adenine N10 atom in the studied compounds had planarsp2-hybridization although it adopted tetrahedralsp3-hybridization with two benzyl groups on it. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
Chemical Constituents from Gentiana urnula
A new compound, named 7-O-(4-β-glucopyranosyloxy-3-hydroxybenzoyl)secologanol (1), together with twelve known compounds (2 –13), were isolated from the whole plants ofGentiana urnula Harry Sm. The structures of these compounds were elucidated by means of HRMS, 1D and 2D NMR. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
Synthesis and Crystal Structure of 2-bromobutoxy-4-methoxy-6-hydroxychalcone
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
New Glycoside of Quercetin from the Genus Prunella
A study of phenolic compounds from four species of the genusPrunella (P. grandiflora,P. laciniata,P. vulgaris, andP. vulgaris subsp.asiatica) led to the isolation of 18 compounds, including the new flavonoid1. UV and NMR spectroscopic and mass spectrometric data established that1 was quercetin 3-O-(4 ′′-O-β-Dxylopyranosyl-6 ′′-O-α-L-rhamnopyranosyl)-β-D-glycopyranoside. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
Pectinic Substances from Leaves of Ficus carica and Morus multicaulis
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
Two New Biphenylpropanoids from the Rhizomes of Acorus tatarinowii
Two new biphenylpropanoids (1 and2) were isolated from the rhizomes ofAcorus tatarinowii Schott. The structures of compounds1 and2 were determined by means of extensive spectroscopic methods. Their structures were identified as (R)-3-[1-hydroxy-3-(3,4-dimethoxyphenyl)propan-2-yl]-4,5-dimethoxy methyl benzoate (1) and (R)-3-[1-hydroxy-3-(3,4-dimethoxyphenyl)propan-2-yl]-4,5-dimethoxy ethyl benzoate (2). In addition, the xanthine oxidase (XOD) inhibitory activity of the isolated compounds was reported. Compounds1 and2 exhibited weak XOD inhibitory activity in the test. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - July 31, 2023 Category: Chemistry Source Type: research
