Newly Synthesized N-Glycosidic Halochalcones Reveal Inhibitory Activity on Pancreatic Triacylglycerol Lipase

In this study, the aim was to synthesizeN-glycosidic halochalcone derivatives and to examine their lipase inhibitory activity. The synthesized chalcones (1 –3) were well known and the data were compatible with previous findings. However, compounds4a/b,5a/b,6a/b, and7 –9 were synthesized for the first time in the current study. Remarkable lipase inhibitory potentials of the synthesized compounds were further confirmed through molecular docking studies. The highest lipase inhibition activity was experimentally identified for compounds2 and5a with IC50 17.7133 ± 0.9648 μg/mL and IC50 22.6521 ± 1.2146 μg/mL, respectively.

Source: Chemistry of Natural Compounds - August 1, 2023 Category: Chemistry Source Type: research