A New Phenolic Glycoside from Kalimeris shimadae
Fifteen phenolic constituents were isolated from the 80% ethanol extract ofKalimeris shimadae, including two phenolic glycosides (1,2), six flavonoids (3 –8), five phenylpropanoids (9 –13), and two lignans (14,15). Their structures were identified by spectroscopic analysis and comparison with literature data. Compound1 was a new glucosyringic acid derivative, whereas compounds2 –14 were first discovered fromK. shimadae. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Chemical Compositions of Lepidium latifolium
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
A New Isocoumarin Glucoside from the Aerial Parts of Aruncus sylvester
A new isocoumarin glucoside, 3S-6-methoxy-8-hydroxy 3-(4-hydroxyphenylethyl)-3,4-dihydroisocoumarin- 8-O-β-D-glucopyranoside (1), along with seven known compounds (2 –8) were isolated from the aerial parts ofAruncus sylvester, and their structures were elucidated based on IR, HR-ESI-MS, 1D and 2D NMR spectroscopic data, and XSA. This is the first report of compounds5 –8 from Aruncus sylvester. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
A New Antrobutenone of Synsepalum dulcificum
A new antrobutenone, syndulone (1), and six known compounds were isolated from the stems ofSynsepalum dulcificum (Schumach.& Thonn.) Daniell (Sapotaceae). The structure of the new antrobutenone was elucidated by chemical and physical evidence. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Lipids and Polysaccharides from Arundo donax Growing in Uzbekistan
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Constituents Isolated from the Fungus Monascus sp.
Further study on a 95% EtOH extract of the red mold rice fermented with the mutant of the fungusMonascus sp. led to the isolation of one new natural pyranoid derivative, namely monascuslactone (1), together with three known compounds. The structure of the new compound was determined as (4S*,6S*)-4-hydroxy-4,6-dimethyltetrahydro-2H-pyran-2-one. The known compounds were identified as monascin (2), ankaflavin (3), and methylN-methyl anthranylate (4). Their structures were elucidated by 1D and 2D NMR spectroscopy together with HR-ESI-MS analysis, and comparison of the spectroscopic data with those reported for structurally rel...
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Secondary Metabolites of Cinnamomum kanehirae
A new 1,3-benzodioxole-4,5-dione, cinnakanehirain (6-methylbenzo[d][1,3]dioxole-4,5-dione (1) and eight known compounds were isolated from the roots ofCinnamomum kanehirae Hayata (Lauraceae). The structure of the new constituent was essentially elucidated by spectral evidence. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Index of Natural Objects
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Commikuanoid D: A New Potent Carbonic Anhydrase-II Inhibitor from the Resin of Commiphora kua
A new compound, commikuanoid D, was isolated from the ethyl acetate fraction ofCommiphora kua resin. The structure was unambiguously elucidated on the basis of complete spectroscopic analysis. Furthermore, the compound displayed potent carbonic anhydrase II inhibition with IC50 of 17.4 ± 0.32 μM. On the other hand, the molecular docking reflected that the acetyl group of the molecule specifically binds with the Zn ion at the active site of CA-II, and the OH group of the compound mediated hydrogen bonding with Gln92, thus blocking the enzyme activity with a good binding score ( ≥ 7 kcal/mol). (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
New Flavonoids of the Genus Scutellaria. I. Scutellarisides I and II from S. titovii and S. catharinae
The composition of phenolic compounds fromScutellaria titovii Juz. andS. catharinae Juz. (Lamiaceae) growing in Kazakhstan was studied for the first time. A total of 26 known compounds and two newO-glycosylflavones (1 and2) were detected. The new flavonoids were elucidated as 5,7,2 ′-trihydroxy-6-methoxyflavone 7,2′-di-O-β-D-glucuronopyranoside (scutellariside I,1) and 5,6,7,4 ′-tetrahydroxyflavanone 7,4′-di-O-β-D-glucuronopyranoside (scutellariside II,2) using UV and NMR spectroscopy and mass spectrometry. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Bibenzyl Derivatives from Dendrobium huoshanense
A new bibenzyl together with four known compounds were isolated from the medicinal plantDendrobium huoshanense. The chemical structures of all the compounds were determined by spectroscopic methods, including 1D and 2D NMR, as well as HR-ESI-MS. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 27, 2024 Category: Chemistry Source Type: research
Chemical Constituents of Dracocephalum paulsenii
(Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 26, 2024 Category: Chemistry Source Type: research
Synthesis of Chalcone Derivatives as COX-2 Inhibitory Activity for Ischemic Stroke Treatment
Cyclooxygenase (COX)-2 is a crucial mediator contributing to blood –brain barrier damage during cerebral ischemia. The ability of target compounds to inhibit COX-1 and COX-2 enzymes was determined. Compound4a showed a high COX-2 inhibitory potency and selectivity, which was higher activity than observed for the positive control celecoxib. A docking study was performed for compound4a to explain its interaction with the COX-2 receptor active site. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 26, 2024 Category: Chemistry Source Type: research
New Chemical Constituents from Artemisia austriaca
Six compounds including the new monoterpene 5R-hydroxy-2,3,6-trimethylcyclohepta-2,6-dien-1-one (1) and the five compounds (2–6) identified as 2α,5β-dihydroxy-β-pinene (2), 4-hydroxyacetophenone (3), syringaldehyde (4), 5-hydroxy-4-isopropylfuran-2(5H)-one (5), and chenopanone (6) were isolated from the aerial part ofArtemisia austriaca and from this plant for the first time. Their molecular formula and chemical structures were established. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 26, 2024 Category: Chemistry Source Type: research
Aggreganoid G, a New Methylene-Bridged Sesquiterpenoid Dimer from Lindera aggregata
Aggreganoid G (1), a new methylene-bridged lindenane sesquiterpenoid dimer was isolated and identified from the roots ofLindera aggregata. The structure was elucidated by spectroscopic analysis including MS, IR, 1D, and 2D NMR spectroscopy. The bioactivity evaluation indicated that compound1 possessed a cytoprotective effect against alcohol-induced oxidative injury in HepG2 cells. (Source: Chemistry of Natural Compounds)
Source: Chemistry of Natural Compounds - January 26, 2024 Category: Chemistry Source Type: research
