Aminomethylation of Quercetin by Tetrahydroisoquinoline Derivatives and Their Biological Activity

Monosubstituted quercetin conjugates were synthesized via Mannich reactions from 1-aryl-(or H)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines in 75 –96% yields. Compounds with antihypoxic activity more effective than that of quercetin were found among them.

Source: Chemistry of Natural Compounds - August 2, 2023 Category: Chemistry Source Type: research