Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata

A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem ofRhamnus crenata, together with eight known compounds2 –9. The structure of new compound1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-α-L-rhamnopyranoside (5), and quercetin 7-O-α-L-rhamnopyranoside (6) showed potent inhibition with IC50 values of 33.18 ± 2.73, 35.52 ± 3.27, 28.05 ± 1.85, and 26.41 ± 3.01 μM, respectively, against LPS-induced NO generation. In addition, compounds3,5, and6 also showed potent DPPH radical scavenging activities with IC50 values of 95.47 ± 6.18, 68.27 ± 5.38, and 66.25 ± 4.20 μM, respectively.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research