A New Macrolide from the Strain Cordyceps spp. from Cell Fusion between Cordyceps militaris and Cordyceps cicadae

A new macrolide cephalolidedifuran A (1), together with two known cephalosporolides B (2), and I (3), was isolated from the fungusCordyceps spp., a strain from cell fusion betweenCordyceps militaris andCordyceps cicadae. Their structures were identified on the basis of 1D and 2D NMR spectroscopy as well as MS. The bioassay for anti-nematode activity of all the isolates showed that compounds1 and3 revealed moderate inhibitory activity against the nematodePanagrellus redivivus, with a mortality ratio of 48.35 and 59.16% at 2.5 mg/mL, respectively. Moreover, compounds1 –3 showed weak inhibitory activity against AChE at the concentration of 100 μM.

Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research