Synthesis and Anti-Vibrio Activity of Gallic Acid Derivatives Containing Acyl Thiourea Phenol

A series of gallic acid derivatives containing acyl thiourea phenol were designed and synthesized with gallic acid as a raw material, and their antibacterial activities were evaluated: the synthesized acyl thiourea phenol derivatives of gallic acid had certain anti-Vibrio activity at 1 mg/mL; compounds4a and4c showed good inhibitory activity againstVibrio harveyi, MIC was 0.0156 mg/mL; compound4f also showed certain anti-Vibrio cholerae activity, MIC was 0.0313 mg/mL; compound4g showed anti-Vibrio parahaemolyticus activity, MIC was 0.0156 mg/mL; this series of compounds has poor inhibitory activity againstVibrio vulnificus. Only compounds4a,4c,4e,4g, and4j have weak inhibitory activity againstVibrio vulnificus, with MIC of 0.125 mg/mL.

Source: Chemistry of Natural Compounds - January 31, 2024 Category: Chemistry Source Type: research