Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5/NF- κB pathway
Pyroptosis of the renal tubular epithelial cells (RTECs) and interstitial inflammation are central pathological characteristics of acute kidney injury (AKI). Pyroptosis acts as a pro-inflammatory form of progr... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 21, 2024 Category: Molecular Biology Authors: Jian Lu, Ya Hou, Si-Xiu Liu, Bo Jin, Jing Liu, Nan Li, Yan Zhu, Qing-Yan Zhang, Cheng Wan, Yuan Feng, Jun Xie and Chun-Ming Jiang Tags: Research Source Type: research
Simulation of gap junction formation reveals critical role of Cys disulfide redox state in connexin hemichannel docking
Video Abstract (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 18, 2024 Category: Molecular Biology Authors: L ászló Héja, Ágnes Simon and Julianna Kardos Tags: Research Source Type: research
Investigation of the impact of bromodomain inhibition on cytoskeleton stability and contraction
Injury to contractile organs such as the heart, vasculature, urinary bladder and gut can stimulate a pathological response that results in loss of normal contractility. PDGF and TGF β are among the most well st... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 16, 2024 Category: Molecular Biology Authors: Alexander Bigger-Allen, Ali Hashemi Gheinani and Rosalyn M. Adam Tags: Research Source Type: research
Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9
Diabetic angiogenesis is closely associated with disabilities and death caused by diabetic microvascular complications. Advanced glycation end products (AGEs) are abnormally accumulated in diabetic patients an... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 15, 2024 Category: Molecular Biology Authors: Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu and Xiaohua Guo Tags: Research Source Type: research
Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice
Prostatitis is a highly prevalent condition that seriously affects men ’s physical and mental health. Although epidemiological investigations have provided evidence of a correlation between insufficient sleep a... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 15, 2024 Category: Molecular Biology Authors: Jia Chen, Wenming Ma, Shaoyu Yue, Dongsheng Li, Lei Chen, Cheng Zhang, Yu Guan, Chun Li, Changqin Jiang, Guiyi Liao, Chaozhao Liang, Hui Wang and Sheng Tai Tags: Research Source Type: research
New trends in cell death: overview of the International Society of Cell Death (ICDS) annual meeting in Johannesburg South Africa (May 19-22, 2023)
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 14, 2024 Category: Molecular Biology Authors: Marianne J. Cronj é, Varsha Gadiyar, Jerry Edward Chipuk, Tugba Bagci-Onder, Dmitri Krysko, Raymond B. Birge, Richard A. Lockshin and Zahra Zakeri Tags: Editorial Source Type: research
Correction: Multiregion WES of metastatic pancreatic neuroendocrine tumors revealed heterogeneity in genomic alterations, immune microenvironment and evolutionary patterns
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 14, 2024 Category: Molecular Biology Authors: Yu Jiang, Yi-han Dong, Shi-wei Zhao, Dong-yu Liu, Ji-yang Zhang, Xiao-ya Xu, Hao Chen, Hao Chen and Jia-bin Jin Tags: Correction Source Type: research
Antidepressant fluoxetine alleviates colitis by reshaping intestinal microenvironment
The impact of antidepressants on Inflammatory bowel diseases (IBD) has been extensively studied. However, the biological effects and molecular mechanisms of antidepressants in alleviating colitis remain unclear. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 12, 2024 Category: Molecular Biology Authors: Shuo Teng, Yi Yang, Wanru Zhang, Xiangji Li, Wenkun Li, Zilu Cui, Li Min and Jing Wu Tags: Research Source Type: research
Research progress of the chemokine/chemokine receptor axes in the oncobiology of multiple myeloma (MM)
The incidence of multiple myeloma (MM), a type of blood cancer affecting monoclonal plasma cells, is rising. Although new drugs and therapies have improved patient outcomes, MM remains incurable. Recent studie... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 12, 2024 Category: Molecular Biology Authors: Jun Du, Zheng Lin, Xue-Hang Fu, Xiao-Ran Gu, Guang Lu and Jian Hou Tags: Review Source Type: research
Investigating the therapeutic effects and mechanisms of Carthamus tinctorius L.-derived nanovesicles in atherosclerosis treatment
This study aimed to investigate the therapeutic effects and mechan... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 12, 2024 Category: Molecular Biology Authors: Rongfeng Yang, Fengxia Lin, Wenlin Wang, Gang Dai, Xiao Ke and Guifu Wu Tags: Research Source Type: research
The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling
The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint regulation, has become a focal point in cancer immunotherapy. In the context of cancer, upregulated PD-L1 on tumor cells ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 12, 2024 Category: Molecular Biology Authors: Tianye Li, Mengke Niu, Jianwei Zhou, Kongming Wu and Ming Yi Tags: Review Source Type: research
Discovery of a novel small molecule as CD47/SIRP α and PD-1/PD-L1 dual inhibitor for cancer immunotherapy
Targeting the tumor microenvironment (TME) has emerged as a promising strategy in cancer treatment, particularly through the utilization of immune checkpoint blockade (ICB) agents such as PD-1/PD-L1 inhibitors... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 11, 2024 Category: Molecular Biology Authors: Shengzhe Jin, Hongfei Wang, Yang Li, Jingwen Yang, Beibei Li, Peishang Shi, Xiangrui Zhang, Xiaowen Zhou, Xiuman Zhou, Xiaoshuang Niu, Menghan Wu, Yahong Wu, Wenjie Zhai, Yuanming Qi, Yanfeng Gao and Wenshan Zhao Tags: Research Source Type: research
Tryptophan metabolism in digestive system tumors: unraveling the pathways and implications
Tryptophan (Trp) metabolism plays a crucial role in influencing the development of digestive system tumors. Dysregulation of Trp and its metabolites has been identified in various digestive system cancers, inc... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 11, 2024 Category: Molecular Biology Authors: Liang Yu, Juan Lu and Weibo Du Tags: Review Source Type: research
The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex
Galectins constitute a class of lectins that specifically interact with β-galactoside sugars in glycoconjugates and are implicated in diverse cellular processes, including transport, autophagy or signaling. Si... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 11, 2024 Category: Molecular Biology Authors: Aleksandra G ędaj, Aleksandra Chorążewska, Krzysztof Ciura, Radosław Karelus, Dominika Żukowska, Martyna Biaduń, Marta Kalka, Małgorzata Zakrzewska, Natalia Porębska and Łukasz Opaliński Tags: Brief Report Source Type: research
Strategies for labelling of exogenous and endogenous extracellular vesicles and their application for in vitro and in vivo functional studies
This review presents a comprehensive overview of labelling strategies for endogenous and exogenous extracellular vesicles, that can be utilised both in vitro and in vivo. It covers a broad spectrum of approach... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 9, 2024 Category: Molecular Biology Authors: Marie Boudna, Andres Delgado Campos, Petra Vychytilova-Faltejskova, Tana Machackova, Ondrej Slaby and Kamila Souckova Tags: Review Source Type: research
