Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis
Although GqPCR activation often leads to cell survival by activating the PI3K/AKT pathway, it was previously shown that in several cell types AKT activity is reduced and leads to JNK activation and apoptosis. ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 28, 2024 Category: Molecular Biology Authors: Guy Nadel, Zhong Yao, Avital Hacohen-Lev-Ran, Ehud Wainstein, Galia Maik-Rachline, Tamar Ziv, Zvi Naor, Arie Admon and Rony Seger Tags: Research Source Type: research
E-cadherin variants associated with oral facial clefts trigger aberrant cell motility in a REG1A-dependent manner
Germline mutations of E-cadherin contribute to hereditary diffuse gastric cancer (HDGC) and congenital malformations, such as oral facial clefts (OFC). However, the molecular mechanisms through which E-cadheri... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 27, 2024 Category: Molecular Biology Authors: Joana Pereira, Soraia Melo, Rui M. Ferreira, Patr ícia Carneiro, Vítor Yang, André F. Maia, João Carvalho, Ceu Figueiredo, José Carlos Machado, Eurico Morais-de-Sá, Raquel Seruca and Joana Figueiredo Tags: Research Source Type: research
KIT mutations and expression: current knowledge and new insights for overcoming IM resistance in GIST
Gastrointestinal stromal tumor (GIST) is the most common sarcoma located in gastrointestinal tract and derived from the interstitial cell of Cajal (ICC) lineage. Both ICC and GIST cells highly rely on KIT sign... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 27, 2024 Category: Molecular Biology Authors: Shishan Zhou, Omar Abdihamid, Fengbo Tan, Haiyan Zhou, Heli Liu, Zhi Li, Sheng Xiao and Bin Li Tags: Review Source Type: research
Palmitoylation of vacuole membrane protein 1 promotes small extracellular vesicle secretion via interaction with ALIX and influences intercellular communication
Small extracellular vesicles (EVs), exemplified by exosomes, mediate intercellular communication by transporting proteins, mRNAs, and miRNAs. Post-translational modifications are involved in controlling small ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 26, 2024 Category: Molecular Biology Authors: Mengyuan Qu, Xinyu Liu, Xiaotong Wang, Zili Li, Liquan Zhou and Honggang Li Tags: Research Source Type: research
The in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes
Coenzyme Q0 (CoQ0), a novel quinone derivative of Antrodia camphorata, has been utilized as a therapeutic agent (including antioxidant, anti-inflammatory, antiangiogenic, antiatherosclerotic, and anticancer agent... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 26, 2024 Category: Molecular Biology Authors: You-Cheng Hseu, Jou-Tsen Yeh, Chithravel Vadivalagan, Siang-Jyun Chen, Yugandhar Vudhya Gowrisankar, Sudhir Pandey, Yuan-Tai Hsu, Hung-Rong Yen, Hui-Chi Huang, Jhih-Hsuan Hseu and Hsin-Ling Yang Tags: Research Source Type: research
Apoptosis dysfunction: unravelling the interplay between ZBP1 activation and viral invasion in innate immune responses
Apoptosis plays a pivotal role in pathogen elimination and maintaining homeostasis. However, viruses have evolved strategies to evade apoptosis, enabling their persistence within the host. Z-DNA binding protei... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 24, 2024 Category: Molecular Biology Authors: Jianhao Zhan, Jisheng Wang, Yuqing Liang, Lisha Wang, Le Huang, Shanshan Liu, Xiaoping Zeng, Erming Zeng and Hongmei Wang Tags: Review Source Type: research
Crosstalk with renal proximal tubule cells drives acidosis-induced inflammatory response and dedifferentiation of fibroblasts via p38-singaling
Tubulointerstitial kidney disease associated microenvironmental dysregulation, like acidification, inflammation and fibrosis, affects tubule cells and fibroblasts. Micromilieu homeostasis influences intracellu... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 24, 2024 Category: Molecular Biology Authors: Marie-Christin Schulz, Michael Kopf and Michael Gekle Tags: Methodology Source Type: research
Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages
Solid tumors such as glioblastoma (GBM) exhibit hypoxic zones that are associated with poor prognosis and immunosuppression through multiple cell intrinsic mechanisms. However, release of extracellular vesicle... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Stoyan Tankov, Marija Petrovic, Marc Lecoultre, Felipe Espinoza, Nadia El-Harane, Viviane Bes, Sylvie Chliate, Darel Martinez Bedoya, Olivier Jordan, Gerrit Borchard, Denis Migliorini, Val érie Dutoit and Paul R. Walker Tags: Research Source Type: research
CD73 mitigates ZEB1 expression in papillary thyroid carcinoma
ZEB1, a core transcription factor involved in epithelial-mesenchymal transition (EMT), is associated with aggressive cancer cell behavior, treatment resistance, and poor prognosis across various tumor types. S... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Samlai Vedovatto, Fernanda Dittrich Oliveira, Luiza Cherobini Pereira, Thamiris Becker Scheffel, Liziane Raquel Beckenkamp, Ana Paula Santin Bertoni, M árcia Rosângela Wink and Guido Lenz Tags: Research Source Type: research
Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis
Paraquat (PQ) is an irreplaceable insecticide in many countries for the advantage of fast-acting and broad-spectrum. However, PQ was classified as the most prevailing poisoning substance for suicide with no sp... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Jing Du, Lingyan Yu, Xinyi Yang, Fangchun Shao, Jun Xia, Weidong Jin, Yinhao Zhang, Guojie Lei, Ying Wang, Yanchun Li and Jun Zhang Tags: Research Source Type: research
Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer ’s disease
Patients with Alzheimer ’s disease (AD) are often co-morbid with unprovoked seizures, making clinical diagnosis and management difficult. Although it has an important role in both AD and epilepsy, abnormal γ-am... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2024 Category: Molecular Biology Authors: Rui Mao, Mengsha Hu, Xuan Liu, Lei Ye, Bingsong Xu, Min Sun, Siyi Xu, Wenxuan Shao, Yi Tan, Yun Xu, Feng Bai and Shu Shu Tags: Research Source Type: research
Regulation of β-cell death by ADP-ribosylhydrolase ARH3 via lipid signaling in insulitis
Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream sig... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 21, 2024 Category: Molecular Biology Authors: Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Mol Tags: Research Source Type: research
TFEB activation triggers pexophagy for functional adaptation during oxidative stress under calcium deficient-conditions
Calcium is a ubiquitous intracellular messenger that regulates the expression of various genes involved in cell proliferation, differentiation, and motility. The involvement of calcium in diverse metabolic pat... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 21, 2024 Category: Molecular Biology Authors: Laxman Manandhar, Raghbendra Kumar Dutta, Pradeep Devkota, Arun Chhetri, Xiaofan Wei, Channy Park, Hyug Moo Kwon and Raekil Park Tags: Research Source Type: research
Phase separation-mediated biomolecular condensates and their relationship to tumor
Phase separation is a cellular phenomenon where macromolecules aggregate or segregate, giving rise to biomolecular condensates resembling "droplets" and forming distinct, membrane-free compartments. This proce... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 21, 2024 Category: Molecular Biology Authors: Xi Wang, Jiameng Liu, Chaoming Mao and Yufei Mao Tags: Review Source Type: research
Chemoproteomics-based profiling reveals potential antimalarial mechanism of Celastrol by disrupting spermidine and protein synthesis
Malaria remains a global health burden, and the emergence and increasing spread of drug resistance to current antimalarials poses a major challenge to malaria control. There is an urgent need to find new drugs... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2024 Category: Molecular Biology Authors: Peng Gao, Jianyou Wang, Huan Tang, Huanhuan Pang, Jiemei Liu, Chen Wang, Fei Xia, Honglin Chen, Liting Xu, Junzhe Zhang, Lixia Yuan, Guang Han, Jigang Wang and Gang Liu Tags: Research Source Type: research
