The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient "Yin-Yang" theory and modern immunology
The changes in T regulatory cell (Treg) and T helper cell (Th) 17 ratios holds paramount importance in ensuring internal homeostasis and disease progression. Recently, novel subsets of Treg and Th17, namely IL... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 6, 2024 Category: Molecular Biology Authors: Huantian Cui, Ning Wang, Hanzhou Li, Yuhong Bian, Weibo Wen, Xiangying Kong and Fudi Wang Tags: Review Source Type: research
GOLGA7 is essential for NRAS trafficking from the Golgi to the plasma membrane but not for its palmitoylation
NRAS mutations are most frequently observed in hematological malignancies and are also common in some solid tumors such as melanoma and colon cancer. Despite its pivotal role in oncogenesis, no effective therapie... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 5, 2024 Category: Molecular Biology Authors: Chenxuan Liu, Bo Jiao, Peihong Wang, Baoyuan Zhang, Jiaming Gao, Donghe Li, Xi Xie, Yunying Yao, Lei Yan, Zhenghong Qin, Ping Liu and Ruibao Ren Tags: Research Source Type: research
Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
Interferon- γ-inducible protein of 10 kDa (IP-10/CXCL10) is a dual-function CXC chemokine that coordinates chemotaxis of activated T cells and natural killer (NK) cells via interaction with its G protein-couple... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 2, 2024 Category: Molecular Biology Authors: Luna Dillemans, Karen Yu, Alexandra De Zutter, Sam Noppen, Mieke Gouwy, Nele Berghmans, Lisa Verhallen, Mirre De Bondt, Lotte Vanbrabant, Stef Brusselmans, Erik Martens, Dominique Schols, Patrick Verschueren, Mette M. Rosenkilde, Pedro Elias Marques, Sofi Tags: Research Source Type: research
Ten-eleven translocation-2-mediated macrophage activation promotes liver regeneration
The remarkable regenerative capacity of the liver enables recovery after radical Hepatocellular carcinoma (HCC) resection. After resection, macrophages secrete interleukin 6 and hepatocyte growth factors to pr... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 2, 2024 Category: Molecular Biology Authors: Yiyuan Chen, Lijun Meng, Nan Xu, Huan Chen, Xuyong Wei, Di Lu, Shuai Wang and Xiao Xu Tags: Research Source Type: research
NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain
Neutrophil extracellular trap (NET) has been implicated in the pathology of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, the specific contributions of NLRP3, a NET-asso... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 2, 2024 Category: Molecular Biology Authors: Da Jeong Byun, Jaeho Lee, Kyungryung Ko and Young-Min Hyun Tags: Research Source Type: research
Ferritin-mediated neutrophil extracellular traps formation and cytokine storm via macrophage scavenger receptor in sepsis-associated lung injury
Sepsis is a severe systemic inflammatory disorder manifested by a dysregulated immune response to infection and multi-organ failure. Numerous studies have shown that elevated ferritin levels exist as an essent... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 2, 2024 Category: Molecular Biology Authors: Hao Zhang, Dan Wu, Yanghanzhao Wang, Yuxin Shi, Yuwen Shao, Fu Zeng, Charles B. Spencer, Lilibeth Ortoga, Dehua Wu and Changhong Miao Tags: Research Source Type: research
Design of stable circular permutants of the GroEL chaperone apical domain
Enhancing protein stability holds paramount significance in biotechnology, therapeutics, and the food industry. Circular permutations offer a distinctive avenue for manipulating protein stability while keeping... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 1, 2024 Category: Molecular Biology Authors: Tatiana N. Melnik, Maria A. Majorina, Daria E. Vorobeva, Galina S. Nagibina, Victoria R. Veselova, Ksenia A. Glukhova, Marina A. Pak, Dmitry N. Ivankov, Vladimir N. Uversky and Bogdan S. Melnik Tags: Research Source Type: research
Mitochondrial dynamics and colorectal cancer biology: mechanisms and potential targets
Colorectal cancer (CRC) is a significant public health concern, and its development is associated with mitochondrial dysfunction. Mitochondria can adapt to the high metabolic demands of cancer cells owing to t... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 1, 2024 Category: Molecular Biology Authors: Zihong Wu, Chong Xiao, Jing Long, Wenbo Huang, Fengming You and Xueke Li Tags: Review Source Type: research
T-type voltage-gated channels, Na+/Ca2+-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degeneration
Inherited retinal degenerations (IRDs) are a group of untreatable and commonly blinding diseases characterized by progressive photoreceptor loss. IRD pathology has been linked to an excessive activation of cyc... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 1, 2024 Category: Molecular Biology Authors: Jie Yan, Lan Wang, Qian-Lu Yang, Qian-Xi Yang, Xinyi He, Yujie Dong, Zhulin Hu, Mathias W. Seeliger, Kangwei Jiao and Fran çois Paquet-Durand Tags: Research Source Type: research
Mechanosensitive channel of large conductance enhances the mechanical stretching-induced upregulation of glycolysis and oxidative metabolism in Schwann cells
Physical exercise directly stretching the peripheral nerve promotes nerve regeneration; however, its action mechanism remains elusive. Our present study aimed to investigate the effects of mechanosensitive cha... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 1, 2024 Category: Molecular Biology Authors: Fangzhen Shan, Nannan Zhang, Xiaoying Yao, Yi Li, Zihao Wang, Chuanji Zhang and Yuzhong Wang Tags: Research Source Type: research
Arginyltransferase 1 modulates p62-driven autophagy via mTORC1/AMPk signaling
Arginyltransferase (Ate1) orchestrates posttranslational protein arginylation, a pivotal regulator of cellular proteolytic processes. In eukaryotic cells, two interconnected systems —the ubiquitin proteasome sy... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 31, 2024 Category: Molecular Biology Authors: Laura V. Bonnet, Anabela Palandri, Jesica B. Flores-Martin and Marta E. Hallak Tags: Research Source Type: research
A time window for rescuing dying retinal ganglion cells
Retinal ganglion cell (RGC) degeneration and death cause vision loss in patients with glaucoma. Regulated cell death, once initiated, is generally considered to be an irreversible process. Recently, we showed ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 31, 2024 Category: Molecular Biology Authors: Wenting You, K èvin Knoops, Iris Boesten, Tos T. J. M. Berendschot, Marc A. M. J. van Zandvoort, Birke J. Benedikter, Carroll A. B. Webers, Chris P. M. Reutelingsperger and Theo G. M. F. Gorgels Tags: Research Source Type: research
Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR). As an adaptive cellular response to hostile microenviron... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 31, 2024 Category: Molecular Biology Authors: Jiang He, You Zhou and Lunquan Sun Tags: Review Source Type: research
The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage
Renal fibrosis significantly contributes to the progressive loss of kidney function in chronic kidney disease (CKD), with alternatively activated M2 macrophages playing a crucial role in this progression. The ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2024 Category: Molecular Biology Authors: Min Pu, Jing Zhang, Fuyan Hong, Yan Wang, Chengwei Zhang, Yongcheng Zeng, Zhenzhen Fang, Weiwei Qi, Xia Yang, Guoquan Gao and Ti Zhou Tags: Research Source Type: research
Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields
Every single cell can communicate with other cells in a paracrine manner via the production of nano-sized extracellular vesicles. This phenomenon is conserved between prokaryotic and eukaryotic cells. In eukar... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2024 Category: Molecular Biology Authors: Halimeh Mobarak, Farzin Javid, Maryam Taghavi Narmi, Narges Mardi, Fatemeh Sadeghsoltani, Parisa Khanicheragh, Samaneh Narimani, Mahdi Mahdipour, Emel Sokullu, Ferzane Valioglu and Reza Rahbarghazi Tags: Review Source Type: research
